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公开(公告)号：US20230074255A1
公开(公告)日：2023-03-09
申请号：US17716348
申请日：2022-04-08
Applicant: Protalix Ltd.
Inventor： Avidor Shulman , Ilya Ruderfer , Tehila Ben-Moshe , Talia Shekhter , Yaniv Azulay , Tali Kizhner , Yoseph Shaaltiel
IPC: C12N9/40
Abstract: Multimeric protein structures comprising at least two alpha-galactosidase monomers being covalently linked to one another via a linking moiety are disclosed herein, as well a process for preparing same, and methods of treating Fabry disease via administration of a multimeric protein structure. The disclosed multimeric protein structures exhibit an improved performance, in terms of enhanced activity and/or a longer lasting activity under both lysosomal conditions and in a serum environment.
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Patent Agency Ranking
公开(公告)号：US11814657B2
公开(公告)日：2023-11-14
申请号：US17555557
申请日：2021-12-20
Applicant: Protalix Ltd.
Inventor： Lilach Chen Zeltsburg , Ilya Ruderfer , Avidor Shulman , Liat Fux , Yulia Ugortsev , Hagit Neta , Sivan Gelley , Elad Lavee Laviad , Yoseph Shaaltiel
Abstract: Modified DNase I protein in which one or more amino acids of a DNase I protein are modified non-cellularly, are provided. The modified DNase I protein exhibits a DNA hydrolytic activity in the presence of actin and an improved DNA hydrolytic activity compared to a homologous non-modified DNase I protein. Processes of preparing the modified DNase I protein and uses thereof in, for example, reducing a DNA content in sputum and/or in treating a disease or condition associated with excess extracellular DNA in a fluid, secretion or tissue of a subject, are also provided.
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公开(公告)号：US09708595B2
公开(公告)日：2017-07-18
申请号：US14936720
申请日：2015-11-10
Applicant: Protalix Ltd.
Inventor： Avidor Shulman , Ilya Ruderfer , Tehila Ben Moshe , Talia Shekhter , Yaniv Azulay , Yoseph Shaaltiel , Tali Kizhner
CPC classification number: C12N9/2465 , A61K38/00 , C12Y302/01022
Abstract: Multimeric protein structures comprising at least two alpha-galactosidase monomers being covalently linked to one another via a linking moiety are disclosed herein, as well a process for preparing same, and methods of treating Fabry disease via administration of a multimeric protein structure. The disclosed multimeric protein structures exhibit an improved performance, in terms of enhanced activity and/or a longer lasting activity under both lysosomal conditions and in a serum environment.
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公开(公告)号：US11225648B2
公开(公告)日：2022-01-18
申请号：US15540264
申请日：2016-01-04
Applicant: Protalix Ltd.
Inventor： Lilach Chen Zeltsburg , Ilya Ruderfer , Avidor Shulman , Liat Fux , Yulia Ugortsev , Hagit Neta , Sivan Gelley , Elad Lavee Laviad , Yoseph Shaaltiel
Abstract: Modified DNase I protein in which one or more amino acids of a DNase I protein are modified non-cellularly, are provided. The modified DNase I protein exhibits a DNA hydrolytic activity in the presence of actin and an improved DNA hydrolytic activity compared to a homologous non-modified DNase I protein. Processes of preparing the modified DNase I protein and uses thereof in, for example, reducing a DNA content in sputum and/or in treating a disease or condition associated with excess extracellular DNA in a fluid, secretion or tissue of a subject, are also provided.
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公开(公告)号：US20190256832A1
公开(公告)日：2019-08-22
申请号：US16356238
申请日：2019-03-18
Applicant: Protalix Ltd.
Inventor： Avidor Shulman , Ilya Ruderfer , Tehila Ben-Moshe , Talia Shekhter , Yaniv Azulay , Tali Kizhner , Yoseph Shaaltiel
IPC: C12N9/40
Abstract: Multimeric protein structures comprising at least two alpha-galactosidase monomers being covalently linked to one another via a linking moiety are disclosed herein, as well a process for preparing same, and methods of treating Fabry disease via administration of a multimeric protein structure. The disclosed multimeric protein structures exhibit an improved performance, in terms of enhanced activity and/or a longer lasting activity under both lysosomal conditions and in a serum environment.
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公开(公告)号：US10280414B2
公开(公告)日：2019-05-07
申请号：US15636753
申请日：2017-06-29
Applicant: Protalix Ltd.
Inventor： Avidor Shulman , Ilya Ruderfer , Tehila Ben-Moshe , Talia Shekhter , Yaniv Azulay , Tali Kizhner , Yoseph Shaaltiel
Abstract: Multimeric protein structures comprising at least two alpha-galactosidase monomers being covalently linked to one another via a linking moiety are disclosed herein, as well a process for preparing same, and methods of treating Fabry disease via administration of a multimeric protein structure. The disclosed multimeric protein structures exhibit an improved performance, in terms of enhanced activity and/or a longer lasting activity under both lysosomal conditions and in a serum environment.
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