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![FUSED DIHYDRO-4H-PYRAZOLO[5,1-C][1,4]OXAZINYL COMPOUNDS AND ANALOGS FOR TREATING CNS DISORDERS](/abs-image/US/2020/01/23/US20200024286A1/abs.jpg.150x150.jpg)
1.发明申请公开(公告)号：US20200024286A1
公开(公告)日：2020-01-23
申请号：US16403734
申请日：2019-05-06
发明人： Milan CHYTIL , Sharon ENGEL , Taleen G. HANANIA , Vadim ALEXANDROV , Emer LEAHY
IPC分类号： C07D498/04 , C07D231/56 , C07D498/20 , C07D498/14 , C07D498/22
摘要： Disclosed are compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein Ring B, A1, A2, R6, w and n1 are defined and described herein; compositions thereof; and methods of use thereof. These compounds are useful for treating a variety of neurological and psychiatric disorders, such as those described herein.
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公开(公告)号：US20220340588A1
公开(公告)日：2022-10-27
申请号：US17145548
申请日：2021-01-11
IPC分类号： C07D493/04 , C07D311/76 , C07D313/08 , C07D307/87
摘要： Disclosed are compounds of formula (I): and pharmaceutical compositions containing such compounds. Methods of treating neurological or psychiatric disease and disorders in a subject in need are also disclosed.
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公开(公告)号：US20220185799A1
公开(公告)日：2022-06-16
申请号：US17452786
申请日：2021-10-29
发明人： Linghong XIE , Philip Glyn JONES , Kerry L. SPEAR , Noel Aaron POWELL , Taleen G. HANANIA , Vadim ALEXANDROV
IPC分类号： C07D405/04 , C07D405/14 , C07D413/14 , C07D493/04 , C07D413/04
摘要： Disclosed are compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, Ra, R1, R2, R3, R4, R6, w and n1 are defined and described herein; compositions thereof; and methods of use thereof. These compounds are useful for treating a variety of neurological and psychiatric disorders, such as those described herein.
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公开(公告)号：US20180118727A1
公开(公告)日：2018-05-03
申请号：US15851836
申请日：2017-12-22
IPC分类号： C07D409/04 , C07D491/048 , C07D495/04 , C07D405/04 , C07D409/14
CPC分类号： C07D409/04 , C07D405/04 , C07D409/14 , C07D491/048 , C07D495/04
摘要： Provided herein are thiophene compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.
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公开(公告)号：US20200277286A1
公开(公告)日：2020-09-03
申请号：US16722048
申请日：2019-12-20
IPC分类号： C07D409/04 , C07D409/14 , C07D491/048 , C07D495/04 , C07D405/04
摘要： Provided herein are thiophene compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.
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公开(公告)号：US20190389845A1
公开(公告)日：2019-12-26
申请号：US16403698
申请日：2019-05-06
发明人： Linghong Xie , Philip Glyn JONES , Kerry L. SPEAR , Noel Aaron POWELL , Taleen G. HANANIA , Vadim ALEXANDROV
IPC分类号： C07D405/04 , C07D405/14 , C07D413/14 , C07D493/04 , C07D413/04
摘要： Disclosed are compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, Ra, R1, R2, R3, R4, R6, w and n1 are defined and described herein; compositions thereof; and methods of use thereof. These compounds are useful for treating a variety of neurological and psychiatric disorders, such as those described herein.
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公开(公告)号：US20180028492A1
公开(公告)日：2018-02-01
申请号：US15663672
申请日：2017-07-28
IPC分类号： A61K31/353 , A61K45/06 , C07D311/76 , C07D313/08 , A61K31/13 , C12P17/06
CPC分类号： A61K31/353 , A61K31/13 , A61K31/352 , A61K45/06 , C07D311/76 , C07D313/08 , C12P17/06
摘要： Compounds of formula I: are disclosed, as are pharmaceutical compositions containing such compounds. Methods of treating neurological or psychiatric diseases and disorders in a subject in need thereof are also disclosed.
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公开(公告)号：US20220387382A1
公开(公告)日：2022-12-08
申请号：US17574702
申请日：2022-01-13
发明人： Liming SHAO , John Emmerson CAMPBELL , Michael Charles HEWITT , Una CAMPBELL , Taleen G. HANANIA
IPC分类号： A61K31/381 , C07D277/60 , C07D333/54 , C07D333/76 , C07D333/78 , C07D495/04 , C07D495/20 , A61K31/435 , A61K31/55 , A61K45/06
摘要： Provided herein are multicyclic compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.
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公开(公告)号：US20210267938A1
公开(公告)日：2021-09-02
申请号：US16952401
申请日：2020-11-19
发明人： Liming SHAO , John Emmerson CAMPBELL , Michael Charles HEWITT , Una CAMPBELL , Taleen G. HANANIA
IPC分类号： A61K31/381 , C07D277/60 , C07D333/54 , C07D333/76 , C07D333/78 , C07D495/04 , C07D495/20 , A61K31/435 , A61K31/55 , A61K45/06
摘要： Provided herein are multicyclic compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.
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公开(公告)号：US20200323819A1
公开(公告)日：2020-10-15
申请号：US16791118
申请日：2020-02-14
发明人： Liming SHAO , John Emmerson CAMPBELL , Michael Charles HEWITT , Una CAMPBELL , Taleen G. HANANIA
IPC分类号： A61K31/381 , C07D277/60 , C07D333/54 , C07D333/76 , C07D333/78 , C07D495/04 , C07D495/20 , A61K31/435 , A61K31/55 , A61K45/06
摘要： Provided herein are multicyclic compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.
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