公开(公告)号：US20100280352A1

公开(公告)日：2010-11-04

申请号：US12770850

申请日：2010-04-30

申请人： Razvan Ioan Ionasec ,  Puneet Sharma ,  Bogdan Georgescu ,  Andrey Torzhkov ,  Fabian Moerchen ,  Gayle M. Wittenberg ,  Dmitriy Fradkin ,  Dorin Comaniciu

发明人： Razvan Ioan Ionasec ,  Puneet Sharma ,  Bogdan Georgescu ,  Andrey Torzhkov ,  Fabian Moerchen ,  Gayle M. Wittenberg ,  Dmitriy Fradkin ,  Dorin Comaniciu

IPC分类号： A61B5/05 ,  A61B5/00 ,  G06F17/50 ,  G06G7/60 ,  G06N5/02

CPC分类号： A61B5/0263 ,  G01R33/56 ,  G01R33/5608 ,  G06F19/00 ,  G06F19/321 ,  G06T17/00 ,  G16H50/20 ,  G16H50/50

摘要： A method and system for generating a patient specific anatomical heart model is disclosed. Volumetric image data, such as computed tomography (CT), echocardiography, or magnetic resonance (MR) image data of a patient's cardiac region is received. Individual models for multiple heart components, such as the left ventricle (LV) endocardium, LV epicardium, right ventricle (RV), left atrium (LA), right atrium (RA), mitral valve, aortic valve, aorta, and pulmonary trunk, are estimated in said volumetric cardiac image data. A multi-component patient specific anatomical heart model is generated by integrating the individual models for each of the heart components. Fluid Structure Interaction (FSI) simulations are performed on the patient specific anatomical model, and patient specific clinical parameters are extracted based on the patient specific heart model and the FSI simulations. Disease progression modeling and risk stratification are performed based on the patient specific clinical parameters.

摘要翻译： 公开了一种用于产生患者特异性解剖心脏模型的方法和系统。 接收患者心脏区域的体积图像数据，例如计算机断层摄影（CT），超声心动图或磁共振（MR）图像数据。 用于多个心脏组件的单独模型，例如左心室（LV）心内膜，LV心外膜，右心室（RV），左心房（LA），右心房（RA），二尖瓣，主动脉瓣，主动脉和肺动脉干， 在所述体积心脏图像数据中估计。 通过对每个心脏组件的各个模型进行整合，产生多组分患者特异性解剖心脏模型。 对患者特异性解剖模型进行流体结构相互作用（FSI）模拟，并根据患者特异性心脏模型和FSI模拟提取患者特异性临床参数。 疾病进展模型和风险分层是根据患者的具体临床参数进行的。

公开(公告)号：US08983809B2

公开(公告)日：2015-03-17

申请号：US13311989

申请日：2011-12-06

申请人： Puneet Sharma ,  Viorel Mihalef ,  Razvan Ioan Ionasec ,  Bogdan Georgescu ,  Dorin Comaniciu

发明人： Puneet Sharma ,  Viorel Mihalef ,  Razvan Ioan Ionasec ,  Bogdan Georgescu ,  Dorin Comaniciu

IPC分类号： G06F17/50 ,  G06F19/00 ,  A61F2/90

CPC分类号： G06F19/3437 ,  A61F2/90 ,  G06F19/00 ,  G06F2217/00 ,  G16H50/50

摘要： A method and system for assessment of virtual stent implantation in an aortic aneurysm is disclosed. A patient-specific 4D anatomical model of the aorta is generated from the 4D medical imaging data. A model representing mechanical properties of the aorta wall is adjusted to reflect changes due to aneurysm growth at a plurality of time stages. A stable deformation configuration of the aorta is generated for each time stages by performing fluid structure interaction (FSI) simulations using the patient-specific 4D anatomical model at each time stage based on the adjusted model representing the mechanical properties of the aorta wall at each time stage. Virtual stent implantation is performed for each stable deformation configuration of the aorta and FSI simulations are performed for each virtual stent implantation.

摘要翻译： 公开了一种用于评估主动脉瘤中虚拟支架植入的方法和系统。 从4D医学成像数据生成主动脉的患者特定的4D解剖模型。 调整表示主动脉壁的机械特性的模型，以反映在多个时间段由于动脉瘤生长引起的变化。 通过使用每个时间阶段使用患者特定的4D解剖模型的流体结构相互作用（FSI）模拟，基于每次代表主动脉壁的机械性质的调整模型，对每个时间阶段产生主动脉的稳定变形构型 阶段。 对于主动脉的每个稳定变形构型执行虚拟支架植入，并且对于每个虚拟支架植入进行FSI模拟。

公开(公告)号：US20110060576A1

公开(公告)日：2011-03-10

申请号：US12825905

申请日：2010-06-29

申请人： Puneet Sharma ,  Bogdan Georgescu ,  Razvan Ioan Ionasec ,  Dorin Comaniciu

发明人： Puneet Sharma ,  Bogdan Georgescu ,  Razvan Ioan Ionasec ,  Dorin Comaniciu

IPC分类号： G06G7/60

CPC分类号： G06T17/00 ,  G06F19/00 ,  G06T7/0012 ,  G06T2207/10072 ,  G06T2207/30048 ,  G16H50/20 ,  G16H50/50

摘要： A method and system for generating a patient specific anatomical heart model is disclosed. A sequence of volumetric image data, such as computed tomography (CT), echocardiography, or magnetic resonance (MR) image data of a patient's cardiac region is received. A multi-component patient specific 4D geometric model of the heart and aorta estimated from the sequence of volumetric cardiac imaging data. A patient specific 4D computational model based on one or more of personalized geometry, material properties, fluid boundary conditions, and flow velocity measurements in the 4D geometric model is generated. Patient specific material properties of the aortic wall are estimated using the 4D geometrical model and the 4D computational model. Fluid Structure Interaction (FSI) simulations are performed using the 4D computational model and estimated material properties of the aortic wall, and patient specific clinical parameters are extracted based on the FSI simulations. Disease progression modeling and risk stratification are performed based on the patient specific clinical parameters.

摘要翻译： 公开了一种用于产生患者特异性解剖心脏模型的方法和系统。 接收患者心脏区域的体积图像数据的序列，例如计算机断层摄影（CT），超声心动图或磁共振（MR）图像数据。 根据体积心脏成像数据序列估计的心脏和主动脉的多组分患者特定4D几何模型。 产生了基于4D几何模型中的个性化几何，材料特性，流体边界条件和流速测量中的一个或多个的患者特定4D计算模型。 使用4D几何模型和4D计算模型估计主动脉壁的患者特异性材料性质。 使用4D计算模型和主动脉壁的估计材料特性进行流体结构相互作用（FSI）模拟，并且基于FSI模拟提取患者特异性临床参数。 疾病进展模型和风险分层是根据患者的具体临床参数进行的。

公开(公告)号：US08682626B2

公开(公告)日：2014-03-25

申请号：US13091076

申请日：2011-04-20

申请人： Razvan Ioan Ionasec ,  Ingmar Voigt ,  Viorel Mihalef ,  Sasa Grbic ,  Dime Vitanovski ,  Yang Wang ,  Yefeng Zheng ,  Bogdan Georgescu ,  Dorin Comaniciu ,  Puneet Sharma ,  Tommaso Mansi

发明人： Razvan Ioan Ionasec ,  Ingmar Voigt ,  Viorel Mihalef ,  Sasa Grbic ,  Dime Vitanovski ,  Yang Wang ,  Yefeng Zheng ,  Bogdan Georgescu ,  Dorin Comaniciu ,  Puneet Sharma ,  Tommaso Mansi

IPC分类号： G06G7/48

CPC分类号： G06T13/20 ,  G06F19/321 ,  G06T2210/24 ,  G06T2210/41 ,  G16H50/50

摘要： A method and system for patient-specific modeling of the whole heart anatomy, dynamics, hemodynamics, and fluid structure interaction from 4D medical image data is disclosed. The anatomy and dynamics of the heart are determined by estimating patient-specific parameters of a physiological model of the heart from the 4D medical image data for a patient. The patient-specific anatomy and dynamics are used as input to a 3D Navier-Stokes solver that derives realistic hemodynamics, constrained by the local anatomy, along the entire heart cycle. Fluid structure interactions are determined iteratively over the heart cycle by simulating the blood flow at a given time step and calculating the deformation of the heart structure based on the simulated blood flow, such that the deformation of the heart structure is used in the simulation of the blood flow at the next time step. The comprehensive patient-specific model of the heart representing anatomy, dynamics, hemodynamics, and fluid structure interaction can be used for non-invasive assessment and diagnosis of the heart, as well as virtual therapy planning and cardiovascular disease management. Parameters of the comprehensive patient-specific model are changed or perturbed to simulate various conditions or treatment options, and then the patient specific model is recalculated to predict the effect of the conditions or treatment options.

摘要翻译： 公开了一种用于针对4D医学图像数据的整个心脏解剖结构，动力学，血流动力学和流体结构相互作用的患者特异性建模的方法和系统。 通过从患者的4D医学图像数据估计心脏的生理模型的患者特异性参数来确定心脏的解剖学和动力学。 患者特异性解剖学和动力学被用作3D Navier-Stokes求解器的输入，该解算器在整个心脏周期中导出由局部解剖结构约束的现实血液动力学。 流体结构相互作用是通过在给定的时间步长模拟血液流动而在心脏周期上迭代地确定的，并且基于模拟的血液流量计算心脏结构的变形，使得心脏结构的变形用于模拟 血液流动在下一个时间步。 代表解剖学，动力学，血液动力学和流体结构相互作用的心脏综合患者特异性模型可用于心脏的非侵入性评估和诊断，以及虚拟治疗计划和心血管疾病管理。 全面的患者特异性模型的参数被改变或扰动以模拟各种条件或治疗选择，然后重新计算患者特异性模型以预测条件或治疗选择的影响。

公开(公告)号：US08527251B2

公开(公告)日：2013-09-03

申请号：US12770850

申请日：2010-04-30

申请人： Razvan Ioan Ionasec ,  Puneet Sharma ,  Bogdan Georgescu ,  Andrey Torzhkov ,  Fabian Moerchen ,  Gayle M. Wittenberg ,  Dmitriy Fradkin ,  Dorin Comaniciu

发明人： Razvan Ioan Ionasec ,  Puneet Sharma ,  Bogdan Georgescu ,  Andrey Torzhkov ,  Fabian Moerchen ,  Gayle M. Wittenberg ,  Dmitriy Fradkin ,  Dorin Comaniciu

IPC分类号： G06G7/58

CPC分类号： A61B5/0263 ,  G01R33/56 ,  G01R33/5608 ,  G06F19/00 ,  G06F19/321 ,  G06T17/00 ,  G16H50/20 ,  G16H50/50

摘要： A method and system for generating a patient specific anatomical heart model is disclosed. Volumetric image data, such as computed tomography (CT), echocardiography, or magnetic resonance (MR) image data of a patient's cardiac region is received. Individual models for multiple heart components, such as the left ventricle (LV) endocardium, LV epicardium, right ventricle (RV), left atrium (LA), right atrium (RA), mitral valve, aortic valve, aorta, and pulmonary trunk, are estimated in said volumetric cardiac image data. A multi-component patient specific anatomical heart model is generated by integrating the individual models for each of the heart components. Fluid Structure Interaction (FSI) simulations are performed on the patient specific anatomical model, and patient specific clinical parameters are extracted based on the patient specific heart model and the FSI simulations. Disease progression modeling and risk stratification are performed based on the patient specific clinical parameters.

摘要翻译： 公开了一种用于生成患者特异性解剖心脏模型的方法和系统。 接收患者心脏区域的体积图像数据，例如计算机断层摄影（CT），超声心动图或磁共振（MR）图像数据。 用于多个心脏组件的单独模型，例如左心室（LV）心内膜，LV心外膜，右心室（RV），左心房（LA），右心房（RA），二尖瓣，主动脉瓣，主动脉和肺动脉干， 在所述体积心脏图像数据中估计。 通过对每个心脏组件的各个模型进行整合，产生多组分患者特异性解剖心脏模型。 对患者特异性解剖模型进行流体结构相互作用（FSI）模拟，并根据患者特异性心脏模型和FSI模拟提取患者特异性临床参数。 疾病进展模型和风险分层是根据患者的具体临床参数进行的。

公开(公告)号：US20120022843A1

公开(公告)日：2012-01-26

申请号：US13091076

申请日：2011-04-20

申请人： Razvan Ioan Ionasec ,  Ingmar Voigt ,  Viorel Mihalef ,  Sasa Grbic ,  Dime Vitanovski ,  Yang Wang ,  Yefeng Zheng ,  Bogdan Georgescu ,  Dorin Comaniciu ,  Puneet Sharma ,  Tommaso Mansi

发明人： Razvan Ioan Ionasec ,  Ingmar Voigt ,  Viorel Mihalef ,  Sasa Grbic ,  Dime Vitanovski ,  Yang Wang ,  Yefeng Zheng ,  Bogdan Georgescu ,  Dorin Comaniciu ,  Puneet Sharma ,  Tommaso Mansi

IPC分类号： G06G7/60 ,  G06G7/57

CPC分类号： G06T13/20 ,  G06F19/321 ,  G06T2210/24 ,  G06T2210/41 ,  G16H50/50

摘要： A method and system for patient-specific modeling of the whole heart anatomy, dynamics, hemodynamics, and fluid structure interaction from 4D medical image data is disclosed. The anatomy and dynamics of the heart are determined by estimating patient-specific parameters of a physiological model of the heart from the 4D medical image data for a patient. The patient-specific anatomy and dynamics are used as input to a 3D Navier-Stokes solver that derives realistic hemodynamics, constrained by the local anatomy, along the entire heart cycle. Fluid structure interactions are determined iteratively over the heart cycle by simulating the blood flow at a given time step and calculating the deformation of the heart structure based on the simulated blood flow, such that the deformation of the heart structure is used in the simulation of the blood flow at the next time step. The comprehensive patient-specific model of the heart representing anatomy, dynamics, hemodynamics, and fluid structure interaction can be used for non-invasive assessment and diagnosis of the heart, as well as virtual therapy planning and cardiovascular disease management. Parameters of the comprehensive patient-specific model are changed or perturbed to simulate various conditions or treatment options, and then the patient specific model is recalculated to predict the effect of the conditions or treatment options.

摘要翻译： 公开了一种用于针对4D医学图像数据的整个心脏解剖结构，动力学，血流动力学和流体结构相互作用的患者特异性建模的方法和系统。 通过从患者的4D医学图像数据估计心脏的生理模型的患者特异性参数来确定心脏的解剖学和动力学。 患者特异性解剖学和动力学被用作3D Navier-Stokes求解器的输入，该解算器在整个心脏周期中导出由局部解剖结构约束的现实血液动力学。 流体结构相互作用是通过在给定的时间步长模拟血液流动而在心脏周期上迭代地确定的，并且基于模拟的血液流量计算心脏结构的变形，使得心脏结构的变形用于模拟 血液流动在下一个时间步。 代表解剖学，动力学，血液动力学和流体结构相互作用的心脏综合患者特异性模型可用于心脏的非侵入性评估和诊断，以及虚拟治疗计划和心血管疾病管理。 全面的患者特异性模型的参数被改变或扰动以模拟各种条件或治疗选择，然后重新计算患者特异性模型以预测条件或治疗选择的影响。

公开(公告)号：US08224640B2

公开(公告)日：2012-07-17

申请号：US12825905

申请日：2010-06-29

申请人： Puneet Sharma ,  Bogdan Georgescu ,  Razvan Ioan Ionasec ,  Dorin Comaniciu

发明人： Puneet Sharma ,  Bogdan Georgescu ,  Razvan Ioan Ionasec ,  Dorin Comaniciu

IPC分类号： G06F19/00 ,  G06F17/10 ,  G06G7/58 ,  G06K9/00

CPC分类号： G06T17/00 ,  G06F19/00 ,  G06T7/0012 ,  G06T2207/10072 ,  G06T2207/30048 ,  G16H50/20 ,  G16H50/50

摘要： A method and system for generating a patient specific anatomical heart model is disclosed. A sequence of volumetric image data, such as computed tomography (CT), echocardiography, or magnetic resonance (MR) image data of a patient's cardiac region is received. A multi-component patient specific 4D geometric model of the heart and aorta estimated from the sequence of volumetric cardiac imaging data. A patient specific 4D computational model based on one or more of personalized geometry, material properties, fluid boundary conditions, and flow velocity measurements in the 4D geometric model is generated. Patient specific material properties of the aortic wall are estimated using the 4D geometrical model and the 4D computational model. Fluid Structure Interaction (FSI) simulations are performed using the 4D computational model and estimated material properties of the aortic wall, and patient specific clinical parameters are extracted based on the FSI simulations. Disease progression modeling and risk stratification are performed based on the patient specific clinical parameters.

摘要翻译： 公开了一种用于产生患者特异性解剖心脏模型的方法和系统。 接收患者心脏区域的体积图像数据的序列，例如计算机断层摄影（CT），超声心动图或磁共振（MR）图像数据。 根据体积心脏成像数据序列估计的心脏和主动脉的多组分患者特定4D几何模型。 产生了基于4D几何模型中的个性化几何，材料特性，流体边界条件和流速测量中的一个或多个的患者特定4D计算模型。 使用4D几何模型和4D计算模型估计主动脉壁的患者特异性材料性质。 使用4D计算模型和主动脉壁的估计材料特性进行流体结构相互作用（FSI）模拟，并且基于FSI模拟提取患者特异性临床参数。 疾病进展模型和风险分层是根据患者的具体临床参数进行的。

公开(公告)号：US09824302B2

公开(公告)日：2017-11-21

申请号：US13412869

申请日：2012-03-06

申请人： Sasa Grbic ,  Razvan Ioan Ionasec ,  Yang Wang ,  Bogdan Georgescu ,  Tommaso Mansi ,  Dorin Comaniciu ,  Yefeng Zheng ,  Shaohua Kevin Zhou ,  Matthias John ,  Jan Boese

发明人： Sasa Grbic ,  Razvan Ioan Ionasec ,  Yang Wang ,  Bogdan Georgescu ,  Tommaso Mansi ,  Dorin Comaniciu ,  Yefeng Zheng ,  Shaohua Kevin Zhou ,  Matthias John ,  Jan Boese

IPC分类号： G06K9/00 ,  G06K9/62

CPC分类号： G06K9/6289 ,  G06K9/6211

摘要： A method and system for fusion of multi-modal volumetric images is disclosed. A first image acquired using a first imaging modality is received. A second image acquired using a second imaging modality is received. A model and of a target anatomical structure and a transformation are jointly estimated from the first and second images. The model represents a model of the target anatomical structure in the first image and the transformation projects a model of the target anatomical structure in the second image to the model in the first image. The first and second images can be fused based on estimated transformation.

公开(公告)号：US20120232853A1

公开(公告)日：2012-09-13

申请号：US13416216

申请日：2012-03-09

申请人： Ingmar Voigt ,  Razvan Ioan Ionasec ,  Bogdan Georgescu ,  Tommaso Mansi ,  Dorin Comaniciu ,  Helene C. Houle ,  Etienne Assoumou Mengue

发明人： Ingmar Voigt ,  Razvan Ioan Ionasec ,  Bogdan Georgescu ,  Tommaso Mansi ,  Dorin Comaniciu ,  Helene C. Houle ,  Etienne Assoumou Mengue

IPC分类号： G06G7/60 ,  G06F17/50

CPC分类号： G06F19/3437 ,  G06F19/00 ,  G06F19/321 ,  G06T7/149 ,  G06T7/344 ,  G06T2207/20081 ,  G06T2207/30048 ,  G16H50/50

摘要： Physically-constrained modeling of a heart is provided. Patient-specific data may be used to estimate heart anatomy locations. A model is applied to the data for estimation. For increased accuracy of estimation, the biomechanics of the heart, such as the valve, may be used to constrain the estimation. By applying a dynamic system between estimated anatomy locations of different times, the locations may be deformed or refined. The modeled heart and/or valve may be used to estimate hemodynamics. The resulting velocities or other motion information may be used to emulate ultrasound Doppler imaging for comparing with acquired ultrasound Doppler data. The comparison may validate the modeling.

摘要翻译： 提供了心脏的物理约束建模。 患者特异性数据可用于估计心脏解剖位置。 将模型应用于数据进行估计。 为了提高估计精度，可以使用心脏的生物力学（例如阀）来限制估计。 通过在不同时间的估计解剖位置之间应用动态系统，位置可以变形或改进。 建模的心脏和/或阀可用于估计血液动力学。 所得到的速度或其他运动信息可用于模拟超声多普勒成像以与获得的超声多普勒数据进行比较。 比较可以验证建模。

公开(公告)号：US20100240996A1

公开(公告)日：2010-09-23

申请号：US12702036

申请日：2010-02-08

申请人： Razvan Ioan Ionasec ,  Ingmar Voigt ,  Yang Wang ,  Bogdan Georgescu ,  Helene C. Houle ,  Dorin Comaniciu ,  Fernando Vega-Higuera

发明人： Razvan Ioan Ionasec ,  Ingmar Voigt ,  Yang Wang ,  Bogdan Georgescu ,  Helene C. Houle ,  Dorin Comaniciu ,  Fernando Vega-Higuera

IPC分类号： A61B8/14 ,  G06K9/62

CPC分类号： G06T7/0016 ,  G06T7/251 ,  G06T7/262 ,  G06T7/277 ,  G06T2207/10016 ,  G06T2207/10076 ,  G06T2207/10136 ,  G06T2207/20016 ,  G06T2207/30048 ,  G06T2207/30241

摘要： Heart valve operation is assessed with patient-specific medical diagnostic imaging data. To deal with the complex motion of the passive valve tissue, a hierarchal model is used. Rigid global motion of the overall valve, non-rigid local motion of landmarks of the valve, and surface motion of the valve are modeled sequentially. For the non-rigid local motion, a spectral trajectory approach is used in the model to determine location and motion of the landmarks more efficiently than detection and tracking. Given efficiencies in processing, more than one valve may be modeled at a same time. A graphic overlay representing the valve in four dimensions and/or quantities may be provided during an imaging session. One or more of these features may be used in combination or independently.

摘要翻译： 心脏瓣膜手术用患者特定的医学诊断成像数据进行评估。 为了处理被动瓣膜组织的复杂运动，使用了层次模型。 总体阀门的刚性全局运动，阀门的标志的非刚性局部运动以及阀门的表面运动被依次建模。 对于非刚性局部运动，在模型中使用频谱轨迹方法，以比检测和跟踪更有效地确定地标的位置和运动。 在处理效率方面，可以同时对多个阀进行建模。 可以在成像会话期间提供表示四维和/或数量的阀的图形覆盖。 这些特征中的一个或多个可以组合使用或独立使用。