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    Method and system for comprehensive patient-specific modeling of the heart
    1.
    发明授权
    Method and system for comprehensive patient-specific modeling of the heart 有权
    心脏综合患者特异性建模的方法和系统

    公开(公告)号：US08682626B2

    公开(公告)日：2014-03-25

    申请号：US13091076

    申请日：2011-04-20

    申请人： Razvan Ioan Ionasec ,  Ingmar Voigt ,  Viorel Mihalef ,  Sasa Grbic ,  Dime Vitanovski ,  Yang Wang ,  Yefeng Zheng ,  Bogdan Georgescu ,  Dorin Comaniciu ,  Puneet Sharma ,  Tommaso Mansi

    发明人： Razvan Ioan Ionasec ,  Ingmar Voigt ,  Viorel Mihalef ,  Sasa Grbic ,  Dime Vitanovski ,  Yang Wang ,  Yefeng Zheng ,  Bogdan Georgescu ,  Dorin Comaniciu ,  Puneet Sharma ,  Tommaso Mansi

    IPC分类号： G06G7/48

    CPC分类号： G06T13/20 ,  G06F19/321 ,  G06T2210/24 ,  G06T2210/41 ,  G16H50/50

    摘要： A method and system for patient-specific modeling of the whole heart anatomy, dynamics, hemodynamics, and fluid structure interaction from 4D medical image data is disclosed. The anatomy and dynamics of the heart are determined by estimating patient-specific parameters of a physiological model of the heart from the 4D medical image data for a patient. The patient-specific anatomy and dynamics are used as input to a 3D Navier-Stokes solver that derives realistic hemodynamics, constrained by the local anatomy, along the entire heart cycle. Fluid structure interactions are determined iteratively over the heart cycle by simulating the blood flow at a given time step and calculating the deformation of the heart structure based on the simulated blood flow, such that the deformation of the heart structure is used in the simulation of the blood flow at the next time step. The comprehensive patient-specific model of the heart representing anatomy, dynamics, hemodynamics, and fluid structure interaction can be used for non-invasive assessment and diagnosis of the heart, as well as virtual therapy planning and cardiovascular disease management. Parameters of the comprehensive patient-specific model are changed or perturbed to simulate various conditions or treatment options, and then the patient specific model is recalculated to predict the effect of the conditions or treatment options.

    摘要翻译： 公开了一种用于针对4D医学图像数据的整个心脏解剖结构，动力学，血流动力学和流体结构相互作用的患者特异性建模的方法和系统。 通过从患者的4D医学图像数据估计心脏的生理模型的患者特异性参数来确定心脏的解剖学和动力学。 患者特异性解剖学和动力学被用作3D Navier-Stokes求解器的输入，该解算器在整个心脏周期中导出由局部解剖结构约束的现实血液动力学。 流体结构相互作用是通过在给定的时间步长模拟血液流动而在心脏周期上迭代地确定的，并且基于模拟的血液流量计算心脏结构的变形，使得心脏结构的变形用于模拟 血液流动在下一个时间步。 代表解剖学，动力学，血液动力学和流体结构相互作用的心脏综合患者特异性模型可用于心脏的非侵入性评估和诊断，以及虚拟治疗计划和心血管疾病管理。 全面的患者特异性模型的参数被改变或扰动以模拟各种条件或治疗选择，然后重新计算患者特异性模型以预测条件或治疗选择的影响。

    Method and System for Comprehensive Patient-Specific Modeling of the Heart
    2.
    发明申请
    Method and System for Comprehensive Patient-Specific Modeling of the Heart 有权
    心脏综合患者特异性建模方法与系统

    公开(公告)号：US20120022843A1

    公开(公告)日：2012-01-26

    申请号：US13091076

    申请日：2011-04-20

    申请人： Razvan Ioan Ionasec ,  Ingmar Voigt ,  Viorel Mihalef ,  Sasa Grbic ,  Dime Vitanovski ,  Yang Wang ,  Yefeng Zheng ,  Bogdan Georgescu ,  Dorin Comaniciu ,  Puneet Sharma ,  Tommaso Mansi

    发明人： Razvan Ioan Ionasec ,  Ingmar Voigt ,  Viorel Mihalef ,  Sasa Grbic ,  Dime Vitanovski ,  Yang Wang ,  Yefeng Zheng ,  Bogdan Georgescu ,  Dorin Comaniciu ,  Puneet Sharma ,  Tommaso Mansi

    IPC分类号： G06G7/60 ,  G06G7/57

    CPC分类号： G06T13/20 ,  G06F19/321 ,  G06T2210/24 ,  G06T2210/41 ,  G16H50/50

    摘要： A method and system for patient-specific modeling of the whole heart anatomy, dynamics, hemodynamics, and fluid structure interaction from 4D medical image data is disclosed. The anatomy and dynamics of the heart are determined by estimating patient-specific parameters of a physiological model of the heart from the 4D medical image data for a patient. The patient-specific anatomy and dynamics are used as input to a 3D Navier-Stokes solver that derives realistic hemodynamics, constrained by the local anatomy, along the entire heart cycle. Fluid structure interactions are determined iteratively over the heart cycle by simulating the blood flow at a given time step and calculating the deformation of the heart structure based on the simulated blood flow, such that the deformation of the heart structure is used in the simulation of the blood flow at the next time step. The comprehensive patient-specific model of the heart representing anatomy, dynamics, hemodynamics, and fluid structure interaction can be used for non-invasive assessment and diagnosis of the heart, as well as virtual therapy planning and cardiovascular disease management. Parameters of the comprehensive patient-specific model are changed or perturbed to simulate various conditions or treatment options, and then the patient specific model is recalculated to predict the effect of the conditions or treatment options.

    摘要翻译： 公开了一种用于针对4D医学图像数据的整个心脏解剖结构，动力学，血流动力学和流体结构相互作用的患者特异性建模的方法和系统。 通过从患者的4D医学图像数据估计心脏的生理模型的患者特异性参数来确定心脏的解剖学和动力学。 患者特异性解剖学和动力学被用作3D Navier-Stokes求解器的输入，该解算器在整个心脏周期中导出由局部解剖结构约束的现实血液动力学。 流体结构相互作用是通过在给定的时间步长模拟血液流动而在心脏周期上迭代地确定的，并且基于模拟的血液流量计算心脏结构的变形，使得心脏结构的变形用于模拟 血液流动在下一个时间步。 代表解剖学，动力学，血液动力学和流体结构相互作用的心脏综合患者特异性模型可用于心脏的非侵入性评估和诊断，以及虚拟治疗计划和心血管疾病管理。 全面的患者特异性模型的参数被改变或扰动以模拟各种条件或治疗选择，然后重新计算患者特异性模型以预测条件或治疗选择的影响。

    Valve treatment simulation from medical diagnostic imaging data
    5.
    发明授权
    Valve treatment simulation from medical diagnostic imaging data 有权
    医疗诊断成像数据的阀门治疗模拟

    公开(公告)号：US08920322B2

    公开(公告)日：2014-12-30

    申请号：US13411711

    申请日：2012-03-05

    申请人： Tommaso Mansi ,  Ingmar Voigt ,  Razvan Ioan Ionasec ,  Bogdan Georgescu ,  Dorin Comaniciu ,  Etienne Assoumou Mengue

    发明人： Tommaso Mansi ,  Ingmar Voigt ,  Razvan Ioan Ionasec ,  Bogdan Georgescu ,  Dorin Comaniciu ,  Etienne Assoumou Mengue

    IPC分类号： A61B8/00 ,  A61B8/08 ,  A61B19/00 ,  G06T19/00 ,  A61B6/00 ,  A61F2/24 ,  G06F19/00

    CPC分类号： A61B8/5238 ,  A61B6/503 ,  A61B6/5229 ,  A61B8/0883 ,  A61B34/10 ,  A61B2034/104 ,  A61F2/24 ,  G06T19/00 ,  G06T2210/41 ,  G16H50/50

    摘要： Valve treatment simulation is performed from patient specific imaging data for therapy planning. A model of the valve may be generated from the patient specific data automatically or with very minimal user indication of anatomy locations relative to an image. Any characteristics for the valve not extracted from images of the patient may be added to create a volumetric model. Added characteristics include chordae, such as chordae length and leaflet fiber direction. The characteristics may be adjusted based on user feedback and/or comparison with images of the patient. The effect of therapy on closure of the valve may be simulated from the model. For instance, mitral clip intervention is simulated on the patient-specific model. Valves are deformed according to the clip location. Valve closure is then simulated to predict effect of the therapy in terms of mitral regurgitation.

    摘要翻译： 从治疗计划的患者特异性成像数据进行瓣膜治疗模拟。 阀的模型可以从患者特定数据自动生成，或者相对于图像的解剖位置的非常小的用户指示来生成。 可以添加不从患者图像中提取的瓣膜的任何特征以产生体积模型。 增加的特征包括腱索，如腱索长度和小叶纤维方向。 可以基于用户反馈和/或与患者的图像进行比较来调整特征。 可以从模型中模拟治疗对瓣膜闭合的影响。 例如，对患者特异性模型模拟二尖瓣夹持干预。 阀门根据夹子位置变形。 然后模拟瓣膜闭合以预测治疗在二尖瓣反流方面的效果。

    VALVE TREATMENT SIMULATION FROM MEDICAL DIAGNOSTIC IMAGING DATA
    6.
    发明申请
    VALVE TREATMENT SIMULATION FROM MEDICAL DIAGNOSTIC IMAGING DATA 有权
    医学诊断成像数据的阀门处理模拟

    公开(公告)号：US20120232386A1

    公开(公告)日：2012-09-13

    申请号：US13411711

    申请日：2012-03-05

    申请人： Tommaso Mansi ,  Ingmar Voigt ,  Razvan Ioan Ionasec ,  Bogdan Georgescu ,  Dorin Comaniciu ,  Etienne Assoumou Mengue

    发明人： Tommaso Mansi ,  Ingmar Voigt ,  Razvan Ioan Ionasec ,  Bogdan Georgescu ,  Dorin Comaniciu ,  Etienne Assoumou Mengue

    IPC分类号： A61B8/00

    CPC分类号： A61B8/5238 ,  A61B6/503 ,  A61B6/5229 ,  A61B8/0883 ,  A61B34/10 ,  A61B2034/104 ,  A61F2/24 ,  G06T19/00 ,  G06T2210/41 ,  G16H50/50

    摘要： Valve treatment simulation is performed from patient specific imaging data for therapy planning. A model of the valve may be generated from the patient specific data automatically or with very minimal user indication of anatomy locations relative to an image. Any characteristics for the valve not extracted from images of the patient may be added to create a volumetric model. Added characteristics include chordae, such as chordae length and leaflet fiber direction. The characteristics may be adjusted based on user feedback and/or comparison with images of the patient. The effect of therapy on closure of the valve may be simulated from the model. For instance, mitral clip intervention is simulated on the patient-specific model. Valves are deformed according to the clip location. Valve closure is then simulated to predict effect of the therapy in terms of mitral regurgitation.

    摘要翻译： 从治疗计划的患者特异性成像数据进行瓣膜治疗模拟。 阀的模型可以从患者特定数据自动生成，或者相对于图像的解剖位置的非常小的用户指示来生成。 可以添加不从患者图像中提取的瓣膜的任何特征以产生体积模型。 增加的特征包括腱索，如腱索长度和小叶纤维方向。 可以基于用户反馈和/或与患者的图像进行比较来调整特征。 可以从模型中模拟治疗对瓣膜闭合的影响。 例如，对患者特异性模型模拟二尖瓣夹持干预。 阀门根据夹子位置变形。 然后模拟瓣膜闭合以预测治疗在二尖瓣反流方面的效果。

    Method and system for advanced measurements computation and therapy planning from medical data and images using a multi-physics fluid-solid heart model
    10.
    发明授权
    Method and system for advanced measurements computation and therapy planning from medical data and images using a multi-physics fluid-solid heart model 有权
    使用多物理流体 - 固体心脏模型的医学数据和图像进行高级测量计算和治疗计划的方法和系统

    公开(公告)号：US09129053B2

    公开(公告)日：2015-09-08

    申请号：US13757517

    申请日：2013-02-01

    申请人： Tommaso Mansi ,  Viorel Mihalef ,  Xudong Zheng ,  Bogdan Georgescu ,  Saikiran Rapaka ,  Puneet Sharma ,  Ali Kamen ,  Dorin Comaniciu

    发明人： Tommaso Mansi ,  Viorel Mihalef ,  Xudong Zheng ,  Bogdan Georgescu ,  Saikiran Rapaka ,  Puneet Sharma ,  Ali Kamen ,  Dorin Comaniciu

    IPC分类号： G06F19/00 ,  G06T19/00

    CPC分类号： G06F19/3437 ,  G06F19/00 ,  G06T19/00 ,  G06T2210/41 ,  G16H50/50

    摘要： Method and system for computation of advanced heart measurements from medical images and data; and therapy planning using a patient-specific multi-physics fluid-solid heart model is disclosed. A patient-specific anatomical model of the left and right ventricles is generated from medical image patient data. A patient-specific computational heart model is generated based on the patient-specific anatomical model of the left and right ventricles and patient-specific clinical data. The computational model includes biomechanics, electrophysiology and hemodynamics. To generate the patient-specific computational heart model, initial patient-specific parameters of an electrophysiology model, initial patient-specific parameters of a biomechanics model, and initial patient-specific computational fluid dynamics (CFD) boundary conditions are marginally estimated. A coupled fluid-structure interaction (FSI) simulation is performed using the initial patient-specific parameters, and the initial patient-specific parameters are refined based on the coupled FSI simulation. The estimated model parameters then constitute new advanced measurements that can be used for decision making.

    摘要翻译： 用于从医学图像和数据计算先进心脏测量的方法和系统; 并且公开了使用患者特定的多物理流体 - 固体心脏模型的治疗计划。 从医学图像患者数据生成左心室和右心室的患者特异性解剖模型。 基于左心室和右心室的患者特异性解剖模型和患者特异性临床数据生成患者特异性计算心脏模型。 计算模型包括生物力学，电生理学和血液动力学。 为了产生患者特异性计算心脏模型，电生理模型的初始患者特异性参数，生物力学模型的初始患者特异性参数和初始患者特异性计算流体动力学（CFD）边界条件被轻微估计。 使用初始患者特异性参数进行耦合的流体结构相互作用（FSI）模拟，并且基于耦合的FSI模拟来改进初始的患者特异性参数。 估计的模型参数然后构成可用于决策的新的高级测量。