公开(公告)号：US10149896B2

公开(公告)日：2018-12-11

申请号：US15412329

申请日：2017-01-23

申请人： Purdue Pharma L.P.

发明人： Donald J. Kyle ,  Daniel A. Soltis ,  Lynda G. Tussey

IPC分类号： A61K38/08 ,  A61K39/00 ,  C07K14/47 ,  C12N9/02 ,  C12N9/12 ,  G01N33/50 ,  G01N33/68 ,  C07K7/06

摘要： The invention provides for the synthesis of more effective generators of a T-cell immune response by providing peptide derivatives that are MHC class I-restricted antigens. The peptide derivatives of the present invention are prepared or derived from a parent peptide of 8 to 11 amino acid residues in length, wherein the peptide derivative contains a non-natural amino acid substituted in place of a naturally-occurring amino acid residue at one or more primary anchor positions in the parent peptide or at position 6, position 7, or the C-terminus.

公开(公告)号：US09549972B2

公开(公告)日：2017-01-24

申请号：US14820194

申请日：2015-08-06

申请人： Purdue Pharma L.P.

发明人： Donald J. Kyle ,  Daniel A. Soltis ,  Lynda G. Tussey

IPC分类号： A61K38/08 ,  C07K4/00 ,  C07K7/06 ,  A61K39/00 ,  C07K14/47 ,  C12N9/02 ,  C12N9/12 ,  G01N33/50 ,  G01N33/68

CPC分类号： A61K39/0005 ,  A61K39/00 ,  C07K7/06 ,  C07K14/4747 ,  C07K14/4748 ,  C12N9/0077 ,  C12N9/1241 ,  G01N33/505 ,  G01N33/6878 ,  G01N2333/70539 ,  G01N2500/04 ,  G01N2500/10

摘要： The invention provides for the synthesis of more effective generators of a T-cell immune response by providing peptide derivatives that are MHC class I-restricted antigens. The peptide derivatives of the present invention are prepared or derived from a parent peptide of 8 to 11 amino acid residues in length, wherein the peptide derivative contains a non-natural amino acid substituted in place of a naturally-occurring amino acid residue at one or more primary anchor positions in the parent peptide or at position 6, position 7, or the C-terminus.

摘要翻译： 本发明通过提供作为MHC I类限制性抗原的肽衍生物来提供更有效的T细胞免疫应答发生器的合成。 本发明的肽衍生物是长度为8至11个氨基酸残基的母体肽制备或衍生的，其中肽衍生物含有非天然氨基酸代替天然存在的氨基酸残基 在母体肽中或位置6，位置7或C-末端具有更多的主要锚定位置。

公开(公告)号：US20170319670A1

公开(公告)日：2017-11-09

申请号：US15412329

申请日：2017-01-23

申请人： Purdue Pharma L.P.

发明人： Donald J. KYLE ,  Daniel A. Soltis ,  Lynda G. Tussey

IPC分类号： A61K39/00 ,  C07K7/06 ,  C07K14/47 ,  G01N33/68 ,  G01N33/50 ,  C12N9/02 ,  C12N9/12

CPC分类号： A61K39/0005 ,  A61K39/00 ,  C07K7/06 ,  C07K14/4747 ,  C07K14/4748 ,  C12N9/0077 ,  C12N9/1241 ,  G01N33/505 ,  G01N33/6878 ,  G01N2333/70539 ,  G01N2500/04 ,  G01N2500/10

摘要： The invention provides for the synthesis of more effective generators of a T-cell immune response by providing peptide derivatives that are MHC class I-restricted antigens. The peptide derivatives of the present invention are prepared or derived from a parent peptide of 8 to 11 amino acid residues in length, wherein the peptide derivative contains a non-natural amino acid substituted in place of a naturally-occurring amino acid residue at one or more primary anchor positions in the parent peptide or at position 6, position 7, or the C-terminus.

公开(公告)号：US20160022787A1

公开(公告)日：2016-01-28

申请号：US14820194

申请日：2015-08-06

申请人： Purdue Pharma L.P.

发明人： Donald J. KYLE ,  Daniel A. Soltis ,  Lynda G. Tussey

IPC分类号： A61K39/00

CPC分类号： A61K39/0005 ,  A61K39/00 ,  C07K7/06 ,  C07K14/4747 ,  C07K14/4748 ,  C12N9/0077 ,  C12N9/1241 ,  G01N33/505 ,  G01N33/6878 ,  G01N2333/70539 ,  G01N2500/04 ,  G01N2500/10

摘要： The invention provides for the synthesis of more effective generators of a T-cell immune response by providing peptide derivatives that are MHC class I-restricted antigens. The peptide derivatives of the present invention are prepared or derived from a parent peptide of 8 to 11 amino acid residues in length, wherein the peptide derivative contains a non-natural amino acid substituted in place of a naturally-occurring amino acid residue at one or more primary anchor positions in the parent peptide or at position 6, position 7, or the C-terminus.

摘要翻译： 本发明通过提供作为MHC I类限制性抗原的肽衍生物来提供更有效的T细胞免疫应答发生器的合成。 本发明的肽衍生物是长度为8至11个氨基酸残基的母体肽制备或衍生的，其中肽衍生物含有非天然氨基酸代替天然存在的氨基酸残基 在母体肽中或位置6，位置7或C-末端具有更多的主要锚定位置。