公开(公告)号：US10689425B2

公开(公告)日：2020-06-23

申请号：US15369489

申请日：2016-12-05

Applicant: Purdue Research Foundation

Inventor： Alyssa Panitch ,  John Eric Paderi ,  Kinam Park ,  Katherine Allison Stuart ,  Steve Higbee

IPC: C07K14/00 ,  A61L27/24 ,  C07K9/00 ,  C07K14/47 ,  A61L27/38 ,  A61L27/54 ,  C07K14/78 ,  A61L27/22 ,  A61K38/00

Abstract: This invention relates to collagen-binding synthetic peptidoglycans and engineered collagen matrices comprising a collagen matrix and a collagen-binding synthetic peptidoglycan where the collagen-binding synthetic peptidoglycan can be aberrant or can have amino acid homology with a portion of the amino acid sequence of a protein or a proteoglycan that regulates collagen fibrillogenesis. The invention also relates to kits, compounds, compositions, and engineered graft constructs comprising such collagen-binding synthetic peptidoglycans or engineered collagen matrices and methods for their preparation and use.

公开(公告)号：US20140288002A1

公开(公告)日：2014-09-25

申请号：US14214220

申请日：2014-03-14

Applicant: Purdue Research Foundation

Inventor： Alyssa Panitch ,  John Eric Paderi ,  Shaili Sharma ,  Katherine Allison Stuart ,  Nelda Marie Vazquez-Portalatin

IPC: C07K9/00

CPC classification number: A61K38/14 ,  A61K47/545 ,  A61K47/61 ,  C07K9/00 ,  C07K14/4725

Abstract: This disclosure provides extracellular matrix-binding synthetic peptidoglycans comprised of one or more synthetic peptides conjugated to a glycan and methods of their use.

Abstract translation: 本公开提供了由缀合至聚糖的一种或多种合成肽组成的细胞外基质结合合成肽聚糖及其使用方法。

公开(公告)号：US20190022175A1

公开(公告)日：2019-01-24

申请号：US15845955

申请日：2017-12-18

Applicant: Purdue Research Foundation

Inventor： Alyssa Panitch ,  John Eric Paderi ,  Shaili Sharma ,  Katherine Allison Stuart ,  Nelda Marie Vasquez-Portalatin

IPC: A61K38/14 ,  C07K14/47 ,  A61K47/61 ,  C07K9/00 ,  A61K47/54

Abstract: This disclosure provides extracellular matrix-binding synthetic peptidoglycans comprised of one or more synthetic peptides conjugated to a glycan and methods of their use.

公开(公告)号：US20180030091A1

公开(公告)日：2018-02-01

申请号：US15713530

申请日：2017-09-22

Applicant: Purdue Research Foundation

Inventor： John Eric Paderi ,  Alyssa Panitch ,  Kinam Park ,  Katherine Allison Stuart

IPC: C07K7/08 ,  C07K7/06

CPC classification number: C07K7/08 ,  A61K31/726 ,  A61K31/727 ,  A61K38/00 ,  A61K38/14 ,  C07K7/06 ,  C07K9/00

Abstract: This invention relates to collagen-binding synthetic peptidoglycans. More particularly, this invention relates to collagen-binding synthetic peptidoglycans for use in vascular intervention procedures. The invention also relates to kits comprising such collagen-binding synthetic peptidoglycans and catheters or stents.

公开(公告)号：US09872887B2

公开(公告)日：2018-01-23

申请号：US14940990

申请日：2015-11-13

Applicant: Purdue Research Foundation

Inventor： Alyssa Panitch ,  John Eric Paderi ,  Shaili Sharma ,  Katherine Allison Stuart ,  Nelda Marie Vazquez-Portalatin

IPC: C07K9/00 ,  A61K38/14 ,  C07K14/47 ,  A61K47/48

CPC classification number: A61K38/14 ,  A61K47/545 ,  A61K47/61 ,  C07K9/00 ,  C07K14/4725

Abstract: This disclosure provides extracellular matrix-binding synthetic peptidoglycans comprised of one or more synthetic peptides conjugated to a glycan and methods of their use.

公开(公告)号：US20170275345A1

公开(公告)日：2017-09-28

申请号：US15369489

申请日：2016-12-05

Applicant: Purdue Research Foundation

Inventor： Alyssa Panitch ,  John Eric Paderi ,  Kinam Park ,  Katherine Allison Stuart ,  Steve Higbee

IPC: C07K14/47 ,  A61L27/22 ,  A61L27/24 ,  A61L27/38 ,  A61L27/54 ,  C07K14/00 ,  C07K14/78 ,  C07K9/00 ,  A61K38/00

Abstract: This invention relates to collagen-binding synthetic peptidoglycans and engineered collagen matrices comprising a collagen matrix and a collagen-binding synthetic peptidoglycan where the collagen-binding synthetic peptidoglycan can be aberrant or can have amino acid homology with a portion of the amino acid sequence of a protein or a proteoglycan that regulates collagen fibrillogenesis. The invention also relates to kits, compounds, compositions, and engineered graft constructs comprising such collagen-binding synthetic peptidoglycans or engineered collagen matrices and methods for their preparation and use.

公开(公告)号：US09512192B2

公开(公告)日：2016-12-06

申请号：US15078885

申请日：2016-03-23

Applicant: Purdue Research Foundation

Inventor： Alyssa Panitch ,  John Eric Paderi ,  Kinam Park ,  Katherine Allison Stuart ,  Steve Higbee

IPC: C07K9/00 ,  A61K38/14 ,  A61K31/726 ,  C07K14/47 ,  A61L27/24 ,  A61L27/38 ,  A61L27/54 ,  C07K14/78 ,  C07K14/00 ,  A61L27/22 ,  A61K38/00

CPC classification number: C07K14/4725 ,  A61K38/00 ,  A61L27/227 ,  A61L27/24 ,  A61L27/3804 ,  A61L27/54 ,  A61L2300/25 ,  A61L2300/42 ,  C07K9/00 ,  C07K9/001 ,  C07K14/00 ,  C07K14/78

Abstract: This invention relates to collagen-binding synthetic peptidoglycans and engineered collagen matrices comprising a collagen matrix and a collagen-binding synthetic peptidoglycan where the collagen-binding synthetic peptidoglycan can be aberrant or can have amino acid homology with a portion of the amino acid sequence of a protein or a proteoglycan that regulates collagen fibrillogenesis. The invention also relates to kits, compounds, compositions, and engineered graft constructs comprising such collagen-binding synthetic peptidoglycans or engineered collagen matrices and methods for their preparation and use.

Abstract translation: 本发明涉及胶原结合合成肽聚糖和包含胶原基质和胶原结合合成肽聚糖的工程胶原基质，其中胶原结合合成肽聚糖可以是异常的，或者可以与氨基酸序列的一部分具有氨基酸同源性 蛋白质或调节胶原纤维发生的蛋白多糖。 本发明还涉及包含这种胶原结合合成肽聚糖或工程化胶原基质的试剂盒，化合物，组合物和工程化移植物构建体及其制备和使用方法。