-
公开(公告)号：US12091693B2
公开(公告)日：2024-09-17
申请号：US17497085
申请日：2021-10-08
IPC分类号： C12N9/48 , A61K31/454 , A61K31/4745 , A61K31/475 , A61K38/00 , A61K47/54 , A61K49/00 , A61K51/04 , C12N9/96
CPC分类号： C12N9/485 , A61K31/454 , A61K31/4745 , A61K31/475 , A61K47/542 , A61K49/0032 , A61K49/0052 , A61K51/0402 , A61K51/0497 , C12N9/96 , A61K38/00 , C12Y304/17021
摘要： Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical compositions containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.
-
公开(公告)号：US11779602B2
公开(公告)日：2023-10-10
申请号：US16253562
申请日：2019-01-22
发明人： Philip Stewart Low , Haiyan Chu , Yingjuan June Lu , Christopher Paul Leamon , Leroy W. Wheeler, II , Michael C. Jensen , James Matthaei
IPC分类号： A61K35/17 , C07K14/725 , C12N5/0783 , A61P35/00 , A61K9/00 , A61K31/365 , A61K31/519 , A61K38/17 , C07K16/44 , C07K16/46
CPC分类号： A61K35/17 , A61K9/0019 , A61K9/0053 , A61K31/365 , A61K31/519 , A61K38/1774 , A61P35/00 , C07K14/7051 , C07K16/44 , C07K16/46 , C12N5/0638 , C07K2317/622
摘要： The present disclosure relates to methods of treating a patient with a cancer by administering to the patient a composition comprising CAR T cells wherein the CAR T cells comprise a CAR and the CAR comprises an E2 anti-fluorescein antibody fragment, and administering to the patient a small molecule linked to a targeting moiety by a linker. The disclosure also relates to compositions for use in such methods.
-
公开(公告)号：US20230158153A1
公开(公告)日：2023-05-25
申请号：US17995806
申请日：2021-04-09
IPC分类号： A61K47/54 , A61P11/00 , C07D401/14 , C07D401/04
CPC分类号： A61K47/545 , A61P11/00 , C07D401/14 , C07D401/04 , A61K47/542
摘要： A compound of the formula (II); a pharmaceutical composition comprising same; and methods for treating a fibrotic disease in a subject.
-
公开(公告)号：US20220409747A1
公开(公告)日：2022-12-29
申请号：US17761508
申请日：2020-09-17
摘要： Fibroblast activation protein (FAP)-targeting compounds (e.g., conjugates); a method for imaging cancer or fibrosis; and methods for treating an inflammatory disease/disorder and cancer.
-
公开(公告)号：US11426472B2
公开(公告)日：2022-08-30
申请号：US17285717
申请日：2019-10-15
IPC分类号： A61K51/04 , A61K47/54 , A61K31/4709 , A61K49/00
摘要： Excessive deposition of extracellular matrix is a hallmark of Idiopathic pulmonary fibrosis (IPF), it is advantageous to target the cells and the mechanisms associated with this process. By targeting myofibroblasts (specialized contractile fibroblasts) that are key for the development of IPF with drugs conjugated with fibroblast activation protein (FAP), this technology helps minimize the production of extracellular matrix in the lungs and provides a new treatment option for patients diagnosed with IPF.
-
公开(公告)号：US11344623B2
公开(公告)日：2022-05-31
申请号：US16942537
申请日：2020-07-29
发明人： Philip Stewart Low , Charity Wayua
IPC分类号： A61K51/04 , A61K49/00 , A61K51/02 , A61K47/54 , A61K31/4409 , A61K31/475 , C07D405/12 , C07D243/12 , A61K38/06 , A61K38/07
摘要： Conjugates are described herein where CCK2R targeting ligands are attached to an active moiety, such as therapeutic agent or an imaging agent, through a linker. The conjugates can be used in the detection, diagnosis, imaging and treatment of cancer.
-
公开(公告)号：US11318121B2
公开(公告)日：2022-05-03
申请号：US17359314
申请日：2021-06-25
IPC分类号： A61K47/54 , A61K51/04 , A61K51/08 , A61K47/64 , A61K31/426 , C07C323/52 , C07D207/416 , A61K49/00 , C07K5/08 , A61K31/4745 , A61K31/475
摘要： Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.
-
公开(公告)号：US20210077468A1
公开(公告)日：2021-03-18
申请号：US17086063
申请日：2020-10-30
IPC分类号： A61K31/426 , C07C323/52 , C07D207/416 , A61K47/54 , A61K49/00 , A61K51/04 , C07K5/08 , A61K31/4745 , A61K31/475 , A61K51/08 , A61K47/64
摘要： Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.
-
公开(公告)号：US10406238B2
公开(公告)日：2019-09-10
申请号：US15572985
申请日：2016-05-11
IPC分类号： A61K31/35 , A61K38/08 , A61K45/06 , A61K47/54 , A61K47/55 , A61P29/00 , A61P35/00 , G01N33/84 , G01N33/533
摘要： The invention described herein pertains to ligand-ionophore conjugates, that may also comprise a linked therapeutic agent or imaging agent, and pharmaceutical compositions containing the conjugates. Also described are methods of using the conjugates for increasing the endosomal accumulation and escape of a therapeutic agent, or an imaging agent.
-
公开(公告)号：US20190002861A1
公开(公告)日：2019-01-03
申请号：US15934974
申请日：2018-03-24
IPC分类号： C12N9/48 , A61K49/00 , A61K31/454 , C12N9/96 , A61K51/04 , A61K47/54 , A61K31/475 , A61K31/4745 , A61K38/00
CPC分类号： C12N9/485 , A61K31/454 , A61K31/4745 , A61K31/475 , A61K38/00 , A61K47/542 , A61K49/0032 , A61K49/0052 , A61K51/0402 , A61K51/0497 , C12N9/96 , C12Y304/17021
摘要： Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical compositions containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.
-
-
-
-
-
-
-
-
-
搜索结果
58 条记录 (耗时 0.031 秒)
