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公开(公告)号：US20190219555A1
公开(公告)日：2019-07-18
申请号：US16245703
申请日：2019-01-11
发明人： Robert Graham Cooks , Roy Helmy , Yangjie Li , Yong Liu
CPC分类号： G01N33/15 , H01J49/0027 , H01J49/0445
摘要： The invention generally relates to methods for analyzing stability of an active pharmaceutical agent. In certain aspects, the methods involve obtaining an active pharmaceutical agent, and distributing the active pharmaceutical agent into one or more microdroplets. The one or more microdroplets including the active pharmaceutical agent are then subjected to one or more conditions that force degradation of the active pharmaceutical agent in each of the one or more microdroplets. The one or more microdroplets are then analyzed to determine a ratio of the active pharmaceutical agent to that of a degradation product of the active pharmaceutical agent, thereby analyzing stability of an active pharmaceutical agent.
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公开(公告)号：US11209411B2
公开(公告)日：2021-12-28
申请号：US16245703
申请日：2019-01-11
发明人： Robert Graham Cooks , Roy Helmy , Yangjie Li , Yong Liu
摘要： The invention generally relates to methods for analyzing stability of an active pharmaceutical agent. In certain aspects, the methods involve obtaining an active pharmaceutical agent, and distributing the active pharmaceutical agent into one or more microdroplets. The one or more microdroplets including the active pharmaceutical agent are then subjected to one or more conditions that force degradation of the active pharmaceutical agent in each of the one or more microdroplets. The one or more microdroplets are then analyzed to determine a ratio of the active pharmaceutical agent to that of a degradation product of the active pharmaceutical agent, thereby analyzing stability of an active pharmaceutical agent.
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