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公开(公告)号：US09778400B2
公开(公告)日：2017-10-03
申请号：US15183382
申请日：2016-06-15
发明人： Justus Chukwunonso Ndukaife , Alexandra Boltasseva , Agbai A. Nnanna , Steven Truitt Wereley , Alexander Kildishev , Vladimir M. Shalaev
CPC分类号： G02B5/008
摘要： A system and method suitable for selection, manipulation, and analysis of individual particles within a fluid medium. The system and method involve manipulating the particles by contacting the fluid medium with a plasmonic nanoantenna, illuminating the plasmonic nanoantenna with a source of light such that the plasmonic nanoantenna acts as a nanoscale heat source resulting in localized heating of the fluid medium creating local gradients in the electrical properties of the fluid medium that yield plasmonic trapping sites in the vicinity of the plasmonic nanoantenna, and applying an alternating current electric field in the fluid medium to create electrothermoplasmonic flow around the plasmonic nanoantenna. The electrothermoplasmonic flow transports at least one of the particles towards the plasmonic nanoantenna and the particle is trapped by at least one of the plasmonic trapping sites.
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公开(公告)号：US10794808B2
公开(公告)日：2020-10-06
申请号：US16072572
申请日：2017-02-03
发明人： Katherine Noel Clayton , Tamara Lea Kinzer-Ursem , Steven Truitt Wereley , Janelle Weslyn Salameh
摘要： Methods and systems suitable for tracking Brownian motion of particles suspended in a fluid and determining the diffusion coefficient of the particles therefrom in order to characterize the particles, their synthesis, and/or their surface modifications. The methods include providing a sample having particles suspended in a fluid, obtaining and recording at least first and second images of the sample wherein the first image obtained at a first time and the second image subsequently obtained at a second time, determining the average displacement of the particles in an area of the first and second images during a time period between the first time and the second time based on the first and second images, and then determining a diffusion coefficient of the particles in the area of the first and second images based on the average displacement of the particles during the time period.
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公开(公告)号：US20160370316A1
公开(公告)日：2016-12-22
申请号：US15183382
申请日：2016-06-15
发明人： Justus Chukwunonso Ndukaife , Alexandra Boltasseva , Agbai A. Nnanna , Steven Truitt Wereley , Alexander Kildishev , Vladimir M. Shalaev
IPC分类号： G01N27/447
CPC分类号： G02B5/008
摘要： A system and method suitable for selection, manipulation, and analysis of individual particles within a fluid medium. The system and method involve manipulating the particles by contacting the fluid medium with a plasmonic nanoantenna, illuminating the plasmonic nanoantenna with a source of light such that the plasmonic nanoantenna acts as a nanoscale heat source resulting in localized heating of the fluid medium creating local gradients in the electrical properties of the fluid medium that yield plasmonic trapping sites in the vicinity of the plasmonic nanoantenna, and applying an alternating current electric field in the fluid medium to create electrothermoplasmonic flow around the plasmonic nanoantenna. The electrothermoplasmonic flow transports at least one of the particles towards the plasmonic nanoantenna and the particle is trapped by at least one of the plasmonic trapping sites.
摘要翻译： 适用于流体介质中单个颗粒的选择，操作和分析的系统和方法。 该系统和方法涉及通过使流体介质与等离子体激元纳米天线接触来操纵颗粒，用光源照射等离子体纳米天线，使得等离子体激元纳米天线作为纳米级热源，导致流体介质的局部加热，从而产生局部梯度 在等离子体激元纳米天线附近产生等离子体俘获位点的流体介质的电性能，以及在流体介质中施加交流电场以在等离子体纳米天线周围产生电热等离子体流。 电热液体流将至少一个颗粒转移到等离子体激元纳米天线，并且颗粒被至少一个等离子体俘获位点捕获。
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公开(公告)号：US11221287B2
公开(公告)日：2022-01-11
申请号：US15846430
申请日：2017-12-19
发明人： Steven Truitt Wereley , Tamara Lea Kinzer-Ursem , Katherine Noel Clayton , Jacqueline Callihan Linnes , Donghoon Lee , Taylor Jo Moehling
摘要： This invention relates to a method for measuring viscosity of a fluid using particle diffusometry (PD). The method finds practical applications in detecting structural and functional changes of a biomolecular composition by comparing the viscosity change as compared with the standard of the biomolecular composition. This method may also find uses in clinical diagnosis and quality control of clinical biological medicines, food and feeds during the process of manufacturing, distribution and consumption.
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公开(公告)号：US10436780B2
公开(公告)日：2019-10-08
申请号：US15174990
申请日：2016-06-06
发明人： Justus C. Ndukaife , Alexander V. Kildishev , Agbai (George) A. Nnanna , Alexandra Boltasseva , Vladimir M. Shalaev , Steven Truitt Wereley
摘要： A particle sensing system which includes a plurality of micro-lenses which focus light from an unfocused or loosely focused light source onto a corresponding plurality of focus regions on a surface containing plasmonic structures. The absorption of light by the plasmonic structures in the focus regions results in heat dissipation in the plasmonic structures and consequently increases surface temperature in the focus regions. When an electrical field is applied to a sample fluid in contact with the surface, multiple electrothermal flows are induced in the fluid which rapidly transport suspended particles to the focus regions on the surface. The particles can then be captured and/or sensed.
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公开(公告)号：US20180195944A1
公开(公告)日：2018-07-12
申请号：US15846430
申请日：2017-12-19
发明人： Steven Truitt Wereley , Tamara Lea Kinzer-Ursem , Katherine Noel Clayton , Jacqueline Callihan Linnes , Donghoon Lee , Taylor Jo Moehling
CPC分类号： G01N11/10 , G01N11/00 , G01N13/00 , G01N15/1429 , G01N2011/006 , G01N2011/008 , G01N2013/003 , G01N2015/0003 , G01N2015/0053
摘要： This invention relates to a method for measuring viscosity of a fluid using particle diffusometry (PD). The method finds practical applications in detecting structural and functional changes of a biomolecular composition by comparing the viscosity change as compared with the standard of the biomolecular composition. This method may also find uses in clinical diagnosis and quality control of clinical biological medicines, food and feeds during the process of manufacturing, distribution and consumption.
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