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1.发明申请公开(公告)号：US20170320992A1
公开(公告)日：2017-11-09
申请号：US15526424
申请日：2015-11-12
发明人： You-Yeon Won , Seunggweon Hong , Hoyoung Lee , Jaeyoung Park , Jaewon Lee
IPC分类号： C08F293/00 , A61K49/22
CPC分类号： C08F293/005 , A61K49/223 , C08G64/18
摘要： This invention provides poly(alkylene carbonate)-based amphiphilic block copolymers, compositions comprising the same, e.g., micelles, and methods of use thereof. This invention further provides methods for preparing the poly(alkylene carbonate)-based amphiphilic block copolymers of the invention.
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公开(公告)号：US20230139528A1
公开(公告)日：2023-05-04
申请号：US18054082
申请日：2022-11-09
发明人： You-Yeon Won , Hyun Chang Kim
摘要： Disclosed herein are fully synthetic polymer-based lung surfactant materials, for the first time, as next generation SRT. In vitro studies on these polymer lung surfactants show that the candidate materials effectively mimic the surface tension controlling properties of currently marketed natural lung surfactants. Further, the polymer lung surfactants have strong protein resistance, which makes this class of materials promising also for potential use in Acute Respiratory Distress Syndrome (ARDS) treatment.
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公开(公告)号：US20210187010A1
公开(公告)日：2021-06-24
申请号：US17107295
申请日：2020-11-30
发明人： You-Yeon Won , Hyun Chang Kim
摘要： Disclosed herein are fully synthetic polymer-based lung surfactant materials, for the first time, as next generation SRT. In vitro studies on these polymer lung surfactants show that the candidate materials effectively mimic the surface tension controlling properties of currently marketed natural lung surfactants. Further, the polymer lung surfactants have strong protein resistance, which makes this class of materials promising also for potential use in Acute Respiratory Distress Syndrome (ARDS) treatment.
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公开(公告)号：US11497764B2
公开(公告)日：2022-11-15
申请号：US17107295
申请日：2020-11-30
发明人： You-Yeon Won , Hyun Chang Kim
摘要： Disclosed herein are fully synthetic polymer-based lung surfactant materials, for the first time, as next generation SRT. In vitro studies on these polymer lung surfactants show that the candidate materials effectively mimic the surface tension controlling properties of currently marketed natural lung surfactants. Further, the polymer lung surfactants have strong protein resistance, which makes this class of materials promising also for potential use in Acute Respiratory Distress Syndrome (ARDS) treatment.
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公开(公告)号：US20220127528A1
公开(公告)日：2022-04-28
申请号：US17422177
申请日：2020-01-10
摘要： The present disclosure relates to novel compositions comprising hydrophilic polymer-conjugated bilirubin-coated radio-luminescent particle or particle aggregates, and methods to make and use the novel compositions. A specific novel PEG-BR/CWO NP system provided in this disclosure comprises a CaWO4 nanoparticle (CWO NP) core encapsulated by a poly(ethylene glycol)-bilirubin conjugate micelle (PEG-BR micelle).
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6.发明公开公开(公告)号：US20230201116A1
公开(公告)日：2023-06-29
申请号：US17926105
申请日：2021-06-01
CPC分类号： A61K9/1075 , A61K47/34
摘要： A formulation and method of micelle production including the steps of dissolving amphiphilic block copolymers in a mixed solvent comprising water and a non-aqueous co-solvent, conducting a single-step dialysis against water or saline in order to produce monodisperse kinetically frozen polymer micelles with DLS size polydispersities less than about 0.2 in aqueous conditions or conducting an evaporation process for removal of non-aqueous solvent content in order to produce monodisperse kinetically frozen polymer micelles with DLS size polydispersities less than about 0.2 in aqueous conditions.
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公开(公告)号：US20200046756A1
公开(公告)日：2020-02-13
申请号：US16660179
申请日：2019-10-22
发明人： You-Yeon Won , Hyun Chang Kim
摘要： Disclosed herein are fully synthetic polymer-based lung surfactant materials, for the first time, as next generation SRT. In vitro studies on these polymer lung surfactants show that the candidate materials effectively mimic the surface tension controlling properties of currently marketed natural lung surfactants. Further, the polymer lung surfactants have strong protein resistance, which makes this class of materials promising also for potential use in Acute Respiratory Distress Syndrome (ARDS) treatment.
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公开(公告)号：US20180153926A1
公开(公告)日：2018-06-07
申请号：US15881723
申请日：2018-01-26
发明人： You-Yeon Won , Hyun Chang Kim
IPC分类号： A61K31/765 , A61K9/00 , A61P11/00 , A61K9/08 , A61K9/107
CPC分类号： A61K31/765 , A61K9/0019 , A61K9/0082 , A61K9/08 , A61K9/107 , A61K9/1075 , A61K47/34 , A61P11/00
摘要： Disclosed herein are fully synthetic polymer-based lung surfactant materials, for the first time, as next generation SRT. In vitro studies on these polymer lung surfactants show that the candidate materials effectively mimic the surface tension controlling properties of currently marketed natural lung surfactants. Further, the polymer lung surfactants have strong protein resistance, which makes this class of materials promising also for potential use in Acute Respiratory Distress Syndrome (ARDS) treatment.
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公开(公告)号：US09782499B2
公开(公告)日：2017-10-10
申请号：US13837705
申请日：2013-03-15
发明人： You-Yeon Won , Ronald P. Andres , Dae Hwan Kim
CPC分类号： A61K49/1857 , A61K41/0052 , A61N5/00 , A61N5/04
摘要： This invention provides block copolymer (BCP) encapsulated nanoparticles. The BCP-encapsulated nanoparticles are used in methods for targeting a tumor, in methods of imaging a tumor and in methods of treating cancer including hyperthermia of tumors. This invention further provides processes for preparation of BCP-encapsulated nanoparticles.
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