公开(公告)号：US11046726B2

公开(公告)日：2021-06-29

申请号：US15928533

申请日：2018-03-22

申请人： QIAGEN SCIENCES, LLC

发明人： Mong Sano Marma ,  Jerzy Olejnik ,  Ilia Korboukh

IPC分类号： C07H19/10 ,  C07H19/14 ,  C07F7/18 ,  C07C323/12 ,  C09B11/24 ,  C09B23/08 ,  C09B1/00 ,  C09B5/24 ,  C09B23/16 ,  C12Q1/6869 ,  C12Q1/6876 ,  C07C323/60 ,  C07D207/46 ,  C12Q1/6811

摘要： The present invention provides methods, compositions, mixtures and kits utilizing deoxynucleoside triphosphates comprising a 3′-O position capped by a group comprising methylenedisulfide as a cleavable protecting group and a detectable label reversibly connected to the nucleobase of said deoxynucleoside. Such compounds provide new possibilities for future sequencing technologies, including but not limited to Sequencing by Synthesis.