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公开(公告)号：US20050171010A1
公开(公告)日：2005-08-04
申请号：US10274557
申请日：2002-10-21
申请人： Qi-Qi Chen , John Griffin , Thomas Jenkins , J. Judice , Martin Linsell , Michael Leadbetter , YongQi Mu
发明人： Qi-Qi Chen , John Griffin , Thomas Jenkins , J. Judice , Martin Linsell , Michael Leadbetter , YongQi Mu
摘要： Novel antibacterial agents that act as multibinding agents are disclosed. The compounds of the invention comprise from 2-10 ligands covalently connected, each of said ligands being capable of binding to a transglycosylase enzyme substrate thereby modulating the biological processes/functions thereof.
摘要翻译： 公开了作为多结合剂的新型抗菌剂。 本发明的化合物包含共价连接的2-10个配体，每个所述配体能够结合转糖基酶底物，从而调节其生物学过程/功能。
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2.发明申请公开(公告)号：US20080103292A1
公开(公告)日：2008-05-01
申请号：US11977377
申请日：2007-10-24
申请人： J. Judice , Paul Fatheree , Bernice Lam , Michael Leadbetter , Martin Linsell , YongQi Mu , Sean Trapp , Guang Yang , Yan Zhu
发明人： J. Judice , Paul Fatheree , Bernice Lam , Michael Leadbetter , Martin Linsell , YongQi Mu , Sean Trapp , Guang Yang , Yan Zhu
IPC分类号： C07K14/00
摘要： Disclosed are derivatives of glycopeptide compounds having at least one substituent of the formula: —Ra—Y—Rb-(Z)x where Ra, Rb, Y, Z and x are as defined, and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.
摘要翻译： 公开了具有至少一个下式的取代基的糖肽化合物的衍生物：<？in-line-formula description =“In-line formula”end =“lead”？> - < （Z） <？in-line-formula description =“In-line Formulas”end =“tail”？>其中R a
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公开(公告)号：US20070042942A1
公开(公告)日：2007-02-22
申请号：US11589614
申请日：2006-10-30
申请人： Martin Linsell , Paul Fatheree , Michael Leadbetter , Yan Zhu , J. Judice
发明人： Martin Linsell , Paul Fatheree , Michael Leadbetter , Yan Zhu , J. Judice
CPC分类号： B82Y5/00 , A61K9/0014 , A61K9/0019 , A61K38/00 , A61K47/40 , A61K47/6951 , C07K9/008
摘要： Disclosed are glycopeptide derivatives substituted at the C-terminus and/or the R-terminus with a substituent that comprises one or more saccharide groups and a carboxy group; and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.
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公开(公告)号：US20050159344A1
公开(公告)日：2005-07-21
申请号：US11080130
申请日：2005-03-15
申请人： Martin Linsell , Paul Fatheree , Michael Leadbetter , Yan Zhu , J. Judice
发明人： Martin Linsell , Paul Fatheree , Michael Leadbetter , Yan Zhu , J. Judice
CPC分类号： B82Y5/00 , A61K9/0014 , A61K9/0019 , A61K38/00 , A61K47/40 , A61K47/6951 , C07K9/008
摘要： Disclosed are glycopeptide derivatives substituted at the C-terminus and/or the R-terminus with a substituent that comprises one or more saccharide groups and a carboxy group; and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.
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公开(公告)号：US20050020488A1
公开(公告)日：2005-01-27
申请号：US10926148
申请日：2004-08-25
申请人： Michael Leadbetter , Martin Linsell , Junning Lee , Jyanwei Liu
发明人： Michael Leadbetter , Martin Linsell , Junning Lee , Jyanwei Liu
摘要： Disclosed are processes for preparing glycopeptide phosphonate derivatives having an amino-containing side chain. Several of the process steps are conducted in a single reaction vessel without isolation of intermediate reaction products, thereby generating less waste and improving the overall efficiency and yield of the process.
摘要翻译： 公开了制备具有含氨基侧链的糖肽膦酸酯衍生物的方法。 几个工艺步骤在单个反应容器中进行，而不分离中间反应产物，从而产生较少的废物并提高该方法的总体效率和产率。
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公开(公告)号：US20060194716A1
公开(公告)日：2006-08-31
申请号：US11410549
申请日：2006-04-25
申请人： Martin Linsell , J. Judice
发明人： Martin Linsell , J. Judice
CPC分类号： B82Y5/00 , A61K9/0014 , A61K9/0019 , A61K38/00 , A61K47/40 , A61K47/6951 , C07K9/008
摘要： Disclosed are derivatives of glycopeptides that are substituted at the C-terminus with a substituent that comprises two or more (e.g. 2, 3, 4, or 5) carboxy (CO2H) groups; and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.
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公开(公告)号：US20050164919A1
公开(公告)日：2005-07-28
申请号：US11083370
申请日：2005-03-18
申请人： Martin Linsell , J. Judice
发明人： Martin Linsell , J. Judice
IPC分类号： A61K9/00 , A61K38/00 , A61K47/40 , A61K47/48 , A61K51/08 , A61P31/04 , C07K9/00 , A61K38/16 , A61K38/14
CPC分类号： B82Y5/00 , A61K9/0014 , A61K9/0019 , A61K38/00 , A61K47/40 , A61K47/6951 , C07K9/008
摘要： Disclosed are derivatives of glycopeptides that are substituted at the C-terminus with a substituent that comprises two or more (e.g. 2, 3, 4, or 5) carboxy (CO2H) groups; and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.
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公开(公告)号：US20050164916A1
公开(公告)日：2005-07-28
申请号：US11037934
申请日：2005-01-18
申请人： Michael Leadbetter , Martin Linsell
发明人： Michael Leadbetter , Martin Linsell
IPC分类号： A61K38/00 , A61K9/00 , A61K9/02 , A61K9/19 , A61K9/20 , A61K9/48 , A61K47/06 , A61K47/12 , A61K47/26 , A61K47/40 , A61K47/48 , A61K51/08 , A61P31/04 , C07F9/38 , C07K1/113 , C07K9/00 , A61K38/16 , A61K38/14
CPC分类号： C07K9/008 , A61K9/0014 , A61K9/0019 , A61K9/0095 , A61K9/02 , A61K9/19 , A61K9/2018 , A61K9/4858 , A61K38/14 , A61K47/06 , A61K47/12 , A61K47/26 , A61K47/40 , A61K47/6951 , B82Y5/00
摘要： Disclosed are glycopeptides that are substituted with one or more substituents each comprising one or more phosphono groups; and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.
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公开(公告)号：US20060264607A1
公开(公告)日：2006-11-23
申请号：US11437066
申请日：2006-05-19
申请人： Michael Leadbetter , Martin Linsell , Junning Lee , Jyanwei Liu
发明人： Michael Leadbetter , Martin Linsell , Junning Lee , Jyanwei Liu
摘要： Disclosed are processes for preparing glycopeptide phosphonate derivatives having an amino-containing side chain. Several of the process steps are conducted in a single reaction vessel without isolation of intermediate reaction products, thereby generating less waste and improving the overall efficiency and yield of the process.
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公开(公告)号：US20060063706A1
公开(公告)日：2006-03-23
申请号：US11265570
申请日：2005-11-02
申请人： Michael Leadbetter , Martin Linsell
发明人： Michael Leadbetter , Martin Linsell
CPC分类号： C07K9/008 , A61K9/0014 , A61K9/0019 , A61K9/0095 , A61K9/02 , A61K9/19 , A61K9/2018 , A61K9/4858 , A61K38/14 , A61K47/06 , A61K47/12 , A61K47/26 , A61K47/40 , A61K47/6951 , B82Y5/00
摘要： Disclosed are glycopeptides that are substituted with one or more substituents each comprising one or more phosphono groups; and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.
摘要翻译： 公开了被一个或多个各自包含一个或多个膦酰基的取代基取代的糖肽; 和含有这些糖肽衍生物的药物组合物。 所公开的糖肽衍生物可用作抗菌剂。
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