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公开(公告)号：US12264119B2
公开(公告)日：2025-04-01
申请号：US18229220
申请日：2023-08-02
Applicant: Qingdao University of Science and Technology
Inventor： Peizhe Cui , Jianguang Qi , Wenhui Xu , Yinglong Wang , Zhaoyou Zhu , Kaiguang Wang , Xin Li , Fanqing Meng , Limei Zhong , Shuli Yin , Lei Han , Jianbo Jia , Zhonghui Zheng
Abstract: A process and a device for continuous flow side-chain alkylation which relate to the technical field of organic synthesis. In this process and the device for continuous flow side-chain alkylation, an ibuprofen raw material is prepared with alkylbenzene as a raw material. This raw material alkylbenzene is easily available and has a low cost, and is suitable for scale-up production. Moreover, an entire preparation process adopts continuous chemical synthesis, and a reaction time of each stage can be precisely controlled, which is beneficial to control a total reaction time and reduce an amount of impurities produced. In this way, a purity and a yield of the ibuprofen raw material are improved. In summary, a continuous synthesis method for side-chain alkylation of alkylbenzene provided by the present disclosure shows a low cost and a high yield.
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公开(公告)号：US11826726B2
公开(公告)日：2023-11-28
申请号：US17860405
申请日：2022-07-08
Applicant: Qingdao University of Science and Technology
Inventor： Yinglong Wang , Peizhe Cui , Zhaoyou Zhu , Fanqing Meng , Xin Li , Jianguang Qi , Limei Zhong , Deping Du , Bingkun Xia , Jianbo Jia , Zuxing Kou
IPC: B01J23/06 , B01J20/20 , B01J37/02 , B01J37/08 , B01J37/10 , B01J35/06 , B01J35/00 , C07C51/347 , B01J35/02
CPC classification number: B01J23/06 , B01J20/20 , B01J35/0013 , B01J35/023 , B01J35/06 , B01J37/0217 , B01J37/0228 , B01J37/0236 , B01J37/088 , C07C51/347
Abstract: The present disclosure provides an active zinc-based catalyst and a preparation method thereof, and use in catalyzing a rearrangement reaction of ibuprofen. The active zinc-based catalyst includes a carbon-based fiber material and nano-zinc oxide supported on a fiber surface of the carbon-based fiber material. The active zinc-based catalyst is introduced with the carbon-based fiber material, and the carbon-based fiber material is capable of increasing a specific surface area of the catalyst, thereby improving a dispersion degree of zinc oxide, increasing the number of catalytic active sites, and significantly improving a catalytic activity. Meanwhile, due to a certain mechanical strength, the carbon-based fiber material is capable of improving a mechanical strength of the catalyst, making the catalyst exist stably in ketal fluid, maintaining a stable morphology of the catalyst, and avoiding or inhibiting reduction of the catalytic active sites, thereby ensuring a catalytic stability.
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公开(公告)号：US11820743B1
公开(公告)日：2023-11-21
申请号：US17882045
申请日：2022-08-05
Applicant: Qingdao University of Science and Technology
Inventor： Peizhe Cui , Xin Li , Yinglong Wang , Zhaoyou Zhu , Kaiguang Wang , Jianguang Qi , Limei Zhong , Zhonghui Zheng , Wenhui Xu , Jianbo Jia , Deping Du
Abstract: The present disclosure belongs to the technical field of chemical separation and purification, and in particular relates to a purification method and device for continuous distillation and separation of an ibuprofen intermediate raw material. The purification method comprises the following steps: carrying out a primary distillation on synthetic liquid to obtain a primary material and recovered 4-methyl-1-pentene, then carrying out a second-stage distillation on the primary material to obtain a second-stage material and a recovered crude toluene product; and carrying out a third-stage distillation on the second-stage material to obtain isobutyl benzene and a recovered crude n-butylbenzene product. Embodiment results show that the purification method provided by the present disclosure is high in product recovery rate and high in product purity, the purity of isobutyl benzene is up to 99.99 wt %, the recovery rate is up to 99.9 wt %, the impurity content is not higher than 50 ppm.
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