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    Method and system for automatic anti-tachycardia pacing
    1.
    发明申请
    Method and system for automatic anti-tachycardia pacing 有权
    自动抗心动过速起搏方法与系统

    公开(公告)号：US20050070967A1

    公开(公告)日：2005-03-31

    申请号：US10914495

    申请日：2004-08-09

    申请人： Qingsheng Zhu ,  Stephen Hahn ,  Steven Girouard

    发明人： Qingsheng Zhu ,  Stephen Hahn ,  Steven Girouard

    IPC分类号： A61N1/362 ,  A61N1/37

    CPC分类号： A61N1/3622 ,  A61N1/3712

    摘要： A method and system for delivering anti-tachycardia pacing is disclosed. A cardiac rhythm management device, such as an implantable pacemaker having anti-tachycardia pacing capability, delivers anti-tachycardia pacing therapy in accordance with an anti-tachycardia pacing protocol upon detection of a terminable arrhythmia. The anti-tachycardia pacing is delivered as a burst of one or more pacing pulses at a specified coupling interval after a sensed ventricular polarization. By sensing if an evoked potential occurs, the device can determine whether or not the anti-tachycardia pacing burst has captured the ventricle and can adjust the coupling interval and/or other parameters accordingly.

    摘要翻译： 公开了用于递送抗心动过速起搏的方法和系统。 具有抗心动过速起搏能力的心脏节律管理装置，例如具有抗心动过速起搏能力的可植入起搏器，在检测到可终止的心律失常时，根据抗心动过速起搏方案提供抗心动过速起搏治疗。 抗心动过速起搏在感测到的心室极化之后以指定的耦合间隔作为一个或多个起搏脉冲的脉冲串发送。 通过感测是否发生诱发电位，该装置可以确定抗心动过速起搏脉冲是否已经捕获到心室，并且可以相应地调整耦合间隔和/或其他参数。

    METHOD AND APPARATUS FOR TERMINATION OF CARDIAC TACHYARRHYTHMIAS
    2.
    发明申请
    METHOD AND APPARATUS FOR TERMINATION OF CARDIAC TACHYARRHYTHMIAS 审中-公开
    方法和装置终止心脏TACHYARRHYTHMIAS

    公开(公告)号：US20060116729A1

    公开(公告)日：2006-06-01

    申请号：US11275943

    申请日：2006-02-06

    申请人： Victor Chen ,  Stephen Hahn

    发明人： Victor Chen ,  Stephen Hahn

    IPC分类号： A61N1/36

    CPC分类号： A61N1/3918

    摘要： An apparatus and method for terminating atrial and ventricular tachyarrhythmias by delivering a voltage pulse to an electrode arrangement that efficiently terminates the tachyarrhythmia. In one embodiment, a voltage pulse is impressed between an electrode located in the coronary sinus and an electrode located lo within the superior vena cava or right atrium which is also coupled to an extravascular electrode. In another embodiment, a voltage pulse is impressed between an electrode located within the right ventricle and electrodes located within the coronary sinus and the superior vena cava that are also coupled to an extravascular electrode.

    摘要翻译： 一种用于通过向有效终止快速性心律失常的电极装置递送电压脉冲来终止心房和心室快速性心律失常的装置和方法。 在一个实施例中，在位于冠状窦的电极和位于上腔静脉或右心房内的电极之间施加电压脉冲，该电极也耦合到血管外电极。 在另一个实施例中，电压脉冲被施加在位于右心室内的电极和位于冠状窦和上腔静脉内的电极之间，所述电极也耦合到血管外电极。

    BIOFILM REMOVAL DEVICE FOR ENDOTRACHEAL TUBES
    4.
    发明申请
    BIOFILM REMOVAL DEVICE FOR ENDOTRACHEAL TUBES 有权

    公开(公告)号：US20220126043A1

    公开(公告)日：2022-04-28

    申请号：US17508955

    申请日：2021-10-22

    申请人： Morgan Bohrer ,  Stephen Hahn ,  Michael L'Ecuyer ,  Alexandra Verne

    发明人： Morgan Bohrer ,  Stephen Hahn ,  Michael L'Ecuyer ,  Alexandra Verne

    IPC分类号： A61M16/04

    摘要： A device for biofilm removal from an endotracheal tube is disclosed. Such a device may include a hollow catheter having a tip, wherein said device is inserted down an endotracheal tube of an orally intubated patient. Said tip may include a cylindrical central portion and a fin configured to dislodge biofilm from the inner lumen of the endotracheal tube as the device is rotated, either manually or mechanically, inside the endotracheal tube. The fin may be configured as a helix and positioned to spiral around said cylindrical central portion of the tip thereby forming a channel, defined by the pitch of said helix, about the circumference of the cylindrical central portion. Biofilm dislodged from the inner surface of the endotracheal tube by the rotational motion of the fin may be retained within the channel until the tip is removed from the endotracheal tube. The device may further comprise a motor for mechanically rotating the catheter and tip. Finally, the device may be configured to interface with a mechanical ventilator such that airflow to an intubated patient is not impeded while said device is used to remove biofilm from the inner surface of the patient's endotracheal tube.

    Combustion control system for an engine utilizing a first fuel and a second fuel
    5.
    发明授权
    Combustion control system for an engine utilizing a first fuel and a second fuel 有权
    用于使用第一燃料和第二燃料的发动机的燃烧控制系统

    公开(公告)号：US07779813B2

    公开(公告)日：2010-08-24

    申请号：US11378203

    申请日：2006-03-17

    申请人： Stephen Hahn

    发明人： Stephen Hahn

    IPC分类号： F02P5/00 ,  F02B7/00

    CPC分类号： F02D41/0025 ,  F02D35/021 ,  F02D35/027 ,  F02D2200/1015 ,  F02P15/08

    摘要： A system for a multi-fuel engine includes adjusting delivery of one or more fuels in response to a condition of an ignition spark in the engine. In one example, the system adjusts one or more fuels in response to spark plug ionization detection to improve performance of the engine.

    摘要翻译： 用于多燃料发动机的系统包括响应于发动机中的点火火花的状况来调节一种或多种燃料的输送。 在一个示例中，系统响应于火花塞离子化检测来调整一种或多种燃料以改善发动机的性能。

    Method and apparatus for controlling anti-tachyarrhythmia pacing using hemodynamic sensor
    6.
    发明申请
    Method and apparatus for controlling anti-tachyarrhythmia pacing using hemodynamic sensor 有权
    使用血液动力学传感器控制抗心律失调起搏的方法和装置

    公开(公告)号：US20070142866A1

    公开(公告)日：2007-06-21

    申请号：US11312082

    申请日：2005-12-20

    申请人： Dan Li ,  Gerrard Carlson ,  Stephen Hahn

    发明人： Dan Li ,  Gerrard Carlson ,  Stephen Hahn

    IPC分类号： A61N1/365

    CPC分类号： A61N1/3622 ,  A61N1/36514

    摘要： A cardiac rhythm management (CRM) system includes an implantable medical device that delivers anti-tachyarrhythmia therapies including anti-tachyarrhythmia pacing (ATP) and at least one hemodynamic sensor that senses a hemodynamic signal. When a tachyarrhythmia episode is detected, the CRM system analyzes the hemodynamic signal to determine whether and/or when to deliver an ATP. In one embodiment, a hemodynamic parameter extracted from the hemodynamic signal is used to predict the potential effective of ATP in terminating the detected tachyarrhythmia episode. In another embodiment, a characteristic feature detected from the hemodynamic signal is used to determine an ATP window during which a delivery of ATP is initiated.

    摘要翻译： 心律管理（CRM）系统包括可植入的医疗装置，其传递抗慢性心律失常疗法，包括抗快速性心律失常起搏（ATP）和至少一种感测血液动力学信号的血液动力学传感器。 当检测到快速性心律失常发作时，CRM系统分析血液动力学信号，以确定是否和/或何时递送ATP。 在一个实施例中，使用从血液动力学信号提取的血液动力学参数来预测ATP在终止检测到的快速性心律失常发作中的潜在有效性。 在另一个实施例中，使用从血液动力学信号检测到的特征特征来确定在其中开始ATP递送的ATP窗口。

    Nitroxides as protectors against oxidatives stress
    8.
    发明授权
    Nitroxides as protectors against oxidatives stress 失效
    硝基氧化物作为抗氧化剂应激的保护剂

    公开(公告)号：US06605619B1

    公开(公告)日：2003-08-12

    申请号：US08473960

    申请日：1995-06-07

    申请人： James B. Mitchell ,  Amran Samuni ,  William G. Degraff ,  Stephen Hahn

    发明人： James B. Mitchell ,  Amran Samuni ,  William G. Degraff ,  Stephen Hahn

    IPC分类号： A01N4340

    CPC分类号： A61K31/45 ,  A61K31/421 ,  A61K31/423 ,  A61K31/445

    摘要： The instant invention is directed to the use of a biologically compatible composition, containing an effective amount of a metal-independent nitroxide compound which is preferably represented by the formula wherein R1 is —CH3; R2 is —C2H5, —C3H7, —C4H9, —C5H11, —C6H13, —CH2—CH(CH3)2, —CHCH3C2H5, or —(CH2)7—CH3, or wherein R1 and R2 together form spirocyclopentane, spirocyclohexane, spirocycloheptane, spirocyclooctane, 5-cholestane, or norbornane, R3 is —O. or —OH, or a physiologically acceptable salt thereof, and a pharmaceutically acceptable carrier, as antioxidants capable of protecting cells, tissues, organs, and whole organisms against the deleterious effects of harmful free radical species generated during oxidative stress.

    摘要翻译： 本发明涉及使用生物相容性组合物，其含有有效量的金属不依赖性的氮氧化合物，其优选地由式R 1表示：-CH 3; R2是-C2H5，-C3H7，-C4H9，-C5H11，-C6H13，-CH2-CH（CH3）2，-CHCH3C2H5或 - （CH2）7-CH3，或其中R1和R2一起形成螺环戊烷，螺环己烷，螺环己烷 ，螺环辛烷，5-胆甾烷或降冰片烷，R3为-O。 或-OH，或其生理上可接受的盐和药学上可接受的载体作为抗氧化剂，其能够保护细胞，组织，器官和整个生物免受氧化应激期间产生的有害自由基物质的有害影响。