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    Miniaturized thermal cycler
    2.
    发明授权
    Miniaturized thermal cycler 失效
    小型化热循环仪

    公开(公告)号：US06509186B1

    公开(公告)日：2003-01-21

    申请号：US09846126

    申请日：2001-05-01

    申请人： Quanbo Zou ,  Uppili Sridhar ,  Yu Chen ,  Tit Meng Lim ,  Emmanuel Selvanayagam Zachariah ,  Tie Yan

    发明人： Quanbo Zou ,  Uppili Sridhar ,  Yu Chen ,  Tit Meng Lim ,  Emmanuel Selvanayagam Zachariah ,  Tie Yan

    IPC分类号： C12M136

    CPC分类号： B01L3/5027 ,  B01L3/5025 ,  B01L7/52 ,  B01L2200/147 ,  B01L2300/0816 ,  B01L2300/0877 ,  B01L2300/1827 ,  B01L2300/1883 ,  B01L2400/0487 ,  B01L2400/0688

    摘要： The invention describes a thermal cycler which permits simultaneous treatment of multiple individual samples in independent thermal protocols, so as to implement large numbers of DNA experiments simultaneously in a short time. The chamber is thermally isolated from its surroundings, heat flow in and out of the unit being limited to one or two specific heat transfer areas. All heating elements are located within these transfer areas and at least one temperature sensor per heating element is positioned close by. Fluid bearing channels that facilitate sending fluid into, and removing fluid from, the chamber are provided. The chambers may be manufactured as integrated arrays to form units in which each cycler chamber has independent temperature and fluid flow control. Two embodiments of the invention are described together with a process for manufacturing them as well as two schemes for making connections to the outside world.

    摘要翻译： 本发明描述了一种热循环仪，其允许在独立热方案中同时处理多个单个样品，从而在短时间内同时实现大量的DNA实验。 该室与其周围热隔离，进出单元的热流限于一个或两个特定的传热区域。 所有加热元件位于这些转移区域内，每个加热元件至少有一个温度传感器靠近。 提供了便于将流体输送到腔室中并从腔室中除去流体的流体轴承通道。 腔室可以被制成集成阵列以形成其中每个循环器腔具有独立温度和流体流量控制的单元。 本发明的两个实施例与制造它们的方法以及用于连接到外部世界的两种方案一起被描述。

    Miniaturized thermal cycler
    3.
    发明授权
    Miniaturized thermal cycler 失效
    小型化热循环仪

    公开(公告)号：US06432695B1

    公开(公告)日：2002-08-13

    申请号：US09785588

    申请日：2001-02-16

    申请人： Quanbo Zou ,  Uppili Sridhar ,  Yu Chen ,  Tit Meng Lim ,  Emmanuel Selvanayagam Zachariah ,  Tie Yan

    发明人： Quanbo Zou ,  Uppili Sridhar ,  Yu Chen ,  Tit Meng Lim ,  Emmanuel Selvanayagam Zachariah ,  Tie Yan

    IPC分类号： C12M134

    CPC分类号： B01L3/5027 ,  B01L3/5025 ,  B01L7/52 ,  B01L2200/147 ,  B01L2300/0816 ,  B01L2300/0877 ,  B01L2300/1827 ,  B01L2300/1883 ,  B01L2400/0487 ,  B01L2400/0688

    摘要： The invention describes a thermal cycler which permits simultaneous treatment of multiple individual samples in independent thermal protocols, so as to implement large numbers of DNA experiments simultaneously in a short time. The chamber is thermally isolated from its surroundings, heat flow in and out of the unit being limited to one or two specific heat transfer areas. All heating elements are located within these transfer areas and at least one temperature sensor per heating element is positioned close by. Fluid bearing channels that facilitate sending fluid into, and removing fluid from, the chamber are provided. The chambers may be manufactured as integrated arrays to form units in which each cycler chamber has independent temperature and fluid flow control. Two embodiments of the invention are described together with a process for manufacturing them.

    摘要翻译： 本发明描述了一种热循环仪，其允许在独立热方案中同时处理多个单个样品，从而在短时间内同时实现大量的DNA实验。 该室与其周围热隔离，进出单元的热流限于一个或两个特定的传热区域。 所有加热元件位于这些转移区域内，每个加热元件至少有一个温度传感器靠近。 提供了便于将流体输送到腔室中并从腔室中除去流体的流体轴承通道。 腔室可以被制成集成阵列以形成其中每个循环器腔具有独立温度和流体流量控制的单元。 本发明的两个实施例与其制造方法一起被描述。