公开(公告)号：US10947575B2

公开(公告)日：2021-03-16

申请号：US16200727

申请日：2018-11-27

申请人： QUANTAMATRIX INC.

发明人： Yong-Gyun Jung ,  Eun-Geun Kim ,  Jung Heon Yoo ,  Sunghoon Kwon ,  Jungil Choi ,  Hee Chan Kim ,  Jung Chan Lee ,  Eui Jong Kim ,  Sang Hoon Song ,  Sei Ick Joo ,  Ji Soo Lee

IPC分类号： G06K9/00 ,  C12Q1/18

摘要： Provided are a rapid antimicrobial susceptibility test, based on an analysis of changes in morphology and growth pattern of a microbial cell under different concentrations of various antimicrobial agents, and an automated cell image analysis system therefor. The antimicrobial susceptibility test is rapidly performed based on an analysis of changes in morphology and growth pattern of a microbial cell under different concentrations of various antimicrobial agents, and this makes it possible to obtain highly reliable test results faster by six to seven times than the standard method recommended by Clinical and Laboratory Standards Institute (CLSI).

公开(公告)号：US10533207B2

公开(公告)日：2020-01-14

申请号：US15518668

申请日：2014-10-16

申请人： QuantaMatrix Inc.

发明人： Yong-Gyun Jung ,  Eun Guen Kim ,  Jung Heon Yoo ,  Kyung-Ock Park ,  Sunghoon Kwon ,  Jungil Choi ,  Hee jin Kim ,  Sung Weon Ryoo ,  Haeun Kim ,  Hyeon Ju Jeoung ,  Eun Hee Lee ,  Hyejin Kim

IPC分类号： C12M1/00 ,  C12M3/00 ,  C12Q1/18 ,  C12Q1/02 ,  C12M1/18 ,  C12M1/12 ,  C12M1/32 ,  C12M1/16 ,  C12M1/14 ,  C12M1/34 ,  C12M1/22 ,  C12Q1/04

摘要： The present invention relates to a novel bioactivity testing structure for single cell tracking using a gelling agent and a bioactivity testing system including the testing structure. The present invention also relates to bioactivity testing, drug susceptibility testing, antibiotic screening, and diagnostic methods using the testing structure. The bioactivity testing structure of the present invention enables very rapid and simple drug susceptibility testing of bacteria, particularly Mycobacterium tuberculosis, drug screening, and bacterial diagnosis. Particularly, the use of the testing structure enables DST and diagnosis of bacteria only by pretreatment without the need to concentrate human sputum samples irrespective of inoculum effect, ensuring rapid, accurate, and simple testing compared to conventional tuberculosis diagnosis or DST systems. In addition, the testing structure of the present invention simultaneously enables the diagnosis and drug susceptibility testing of tuberculosis. Therefore, the present invention provides an effective alternative to the prior art.