公开(公告)号：US20190169684A1

公开(公告)日：2019-06-06

申请号：US16169756

申请日：2018-10-24

Applicant: Quantum Biosystems Inc.

Inventor： Mark F. OLDHAM ,  Eric S. NORDMAN ,  Timothy M. WOUDENBERG ,  Gaurav GOYAL ,  Masoud VAKILI ,  Toshihiko HONKURA ,  Sam WOO ,  Hisao KAWASAKI ,  Kazusuke MIHARA

IPC: C12Q1/6869 ,  G01N27/327

Abstract: The present disclosure provides systems and methods for sequencing nucleic acid molecules using tunneling labels. A sequence of a nucleic acid molecule may be identified with high accuracy using a chip comprising sensors, wherein each individual sensor may comprise at least two electrodes separated by a gap. The electrodes may be configured to generate at least one electrical signal upon binding of a tunneling label associated with a nucleotide. Epigenetic information can also be determined at the same time as a nucleic acid sequence.

公开(公告)号：US20210238672A1

公开(公告)日：2021-08-05

申请号：US17238090

申请日：2021-04-22

Applicant: Quantum Biosystems Inc.

Inventor： Eric S. NORDMAN ,  Valentin DIMITROV ,  Gaurav GOYAL ,  Jessica KILLIAN ,  Kazusuke MIHARA

IPC: C12Q1/6869 ,  C12Q1/00 ,  C12Q1/48

Abstract: The present disclosure provides methods and systems for detecting or analyzing a biomolecule. The methods and systems may comprise the use of a plurality of electrodes and a solution which may comprise a variety of reagents. In an example, the solution may comprise one or more redox-active molecules or compounds which may undergo or facilitate a redox cycling process. The redox cycling process may generate an electric signal that may be measured by one or more of the plurality of electrodes. An introduction of a nucleotide having a redox cycling current modifying particle coupled thereto to the solution may result in a change in the electric signal. The change in the electric signal may be used to identify the biomolecule or a portion thereof.