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    Nano-gap electrode pair and method of manufacturing same
    1.
    发明授权
    Nano-gap electrode pair and method of manufacturing same 有权

    公开(公告)号：US10261066B2

    公开(公告)日：2019-04-16

    申请号：US15098147

    申请日：2016-04-13

    Applicant: Quantum Biosystems Inc.

    Inventor： Shuji Ikeda ,  Mark Oldham ,  Eric S. Nordman

    IPC: G01N27/447 ,  G01N33/487 ,  C23C16/455 ,  G01N27/327

    Abstract: A system for detecting a biomolecule comprises a nano-gap electrode device including a first electrode and a second electrode adjacent to the first electrode. The first electrode can be separated from the second electrode by a nano-gap that is dimensioned to permit the biomolecule to flow through the nano-gap. The nano-gap can have at least a first gap region and a second gap region. The second gap region can be oriented at an angle that is greater than zero degrees with respect to a plane having the first gap region. The system can further include an electrical circuit coupled to the nano-gap electrode device. The electrical circuit can receive electrical signals from the first electrode and the second electrode upon the flow of the biomolecule through the nano-gap.

    DEVICES, SYSTEMS AND METHODS FOR NUCLEIC ACID SEQUENCING
    2.
    发明申请
    DEVICES, SYSTEMS AND METHODS FOR NUCLEIC ACID SEQUENCING 审中-公开

    公开(公告)号：US20190071720A1

    公开(公告)日：2019-03-07

    申请号：US15937327

    申请日：2018-03-27

    Applicant: Quantum Biosystems Inc.

    Inventor： Eric S. Nordman ,  Mark Oldham ,  Takeshi Akatsu

    IPC: C12Q1/6869

    Abstract: The present disclosure provides devices, systems and methods for sequencing nucleic acid molecules. A sequence of a nucleic acid molecule may be identified at high accuracy using a chip comprising an array of sensors, wherein each individual sensor comprises at least one nano-gap electrode pair configured to generate electrical signals upon flow of the nucleic acid molecule through or in proximity to at least one nano-gap of the nano-gap electrode pair.

    DEVICES, SYSTEMS AND METHODS FOR SEQUENCING BIOMOLECULES
    4.
    发明申请
    DEVICES, SYSTEMS AND METHODS FOR SEQUENCING BIOMOLECULES 审中-公开
    用于测序生物分子的装置，系统和方法

    公开(公告)号：US20160377591A1

    公开(公告)日：2016-12-29

    申请号：US15217821

    申请日：2016-07-22

    Applicant: Quantum Biosystems Inc.

    Inventor： Tomoji Kawai ,  Masateru Taniguchi ,  Takahito Ohshiro ,  Mark Floyd Oldham ,  Eric Scott Nordman

    IPC: G01N33/487 ,  G01N27/447 ,  C12Q1/68

    CPC classification number: G01N33/48721 ,  C12Q1/6869 ,  G01N27/4473 ,  G01N27/44791 ,  C12Q2563/116 ,  C12Q2563/157 ,  C12Q2565/631

    Abstract: The present disclosure provides a biomolecule sequencing device that includes at least one set of nano-gap electrodes arranged so that a current flows when a biomolecule contained in a sample passes in proximity to the set of nano-gap electrodes, an electrophoresis electrode pair for forming an electric field for moving the biomolecule between the electrodes of the set of nano-gap electrodes, a flow path for flowing the sample in a direction towards the nano-gap electrode pair, a flow path for flowing the sample in a direction away from the nano-gap electrode pair, a measurement unit configured to measure a tunnel current generated when the biomolecule passes between the electrodes of the nano-gap electrode pair with an electric field being formed, and an identification unit configured to sequence the biomolecule.

    Abstract translation: 本公开提供了一种生物分子测序装置，其包括至少一组纳米间隙电极组，所述至少一组纳米间隙电极被布置成当包含在样品中的生物分子通过一组纳米间隙电极时电流流动，用于形成的电泳对 用于在所述一组纳米间隙电极的电极之间移动所述生物分子的电场，用于使样品沿着朝向所述纳米间隙电极对的方向流动的流动路径，用于使样品沿远离所述纳米间隙电极对的方向流动的流动路径 纳米间隙电极对，测量单元，其被配置为测量当所述生物分子在所述纳米间隙电极对的电极之间通过所形成的电场时产生的隧道电流;以及识别单元，被配置为对所述生物分子进行排序。

    Biomolecule sequencing devices, systems and methods
    5.
    发明授权
    Biomolecule sequencing devices, systems and methods 有权

    公开(公告)号：US10557167B2

    公开(公告)日：2020-02-11

    申请号：US15448317

    申请日：2017-03-02

    Applicant: Quantum Biosystems Inc.

    Inventor： Tomoji Kawai ,  Masateru Taniguchi ,  Takahito Ohshiro ,  Mark Oldham ,  Eric Nordman

    IPC: C12Q1/68 ,  G06F19/22 ,  G01N27/04 ,  C12Q1/6869 ,  G16B30/00

    Abstract: Devices, systems and methods for sequencing protein samples are provided. In some examples, currents generated when a monomer passes through between electrodes of a nanogap electrode pair are measured for each of several different distances, so that monomers are identified when compared to a reference physical quantity of a known monomer, which may be obtained from a current measured with a similar inter-electrode distance(s) at which each of plural kinds of monomers are identifiable and ordered with predetermined accuracy and based on a detected physical quantity obtained from a tunneling current, which may be further normalized by the use of one or more reference substances.

    Nano-gap electrode pair and method of manufacturing same
    6.
    发明授权
    Nano-gap electrode pair and method of manufacturing same 有权

    公开(公告)号：US10466228B2

    公开(公告)日：2019-11-05

    申请号：US16178924

    申请日：2018-11-02

    Applicant: Quantum Biosystems Inc.

    Inventor： Shuji Ikeda ,  Mark Oldham ,  Eric S. Nordman

    IPC: G01N27/447 ,  G01N33/487 ,  C23C16/455 ,  G01N27/327

    Abstract: A system for detecting a biomolecule comprises a nano-gap electrode device including a first electrode and a second electrode adjacent to the first electrode. The first electrode can be separated from the second electrode by a nano-gap that is dimensioned to permit the biomolecule to flow through the nano-gap. The nano-gap can have at least a first gap region and a second gap region. The second gap region can be oriented at an angle that is greater than zero degrees with respect to a plane having the first gap region. The system can further include an electrical circuit coupled to the nano-gap electrode device. The electrical circuit can receive electrical signals from the first electrode and the second electrode upon the flow of the biomolecule through the nano-gap.

    SYSTEMS AND METHODS FOR BIOLOGICAL DATA MANAGEMENT
    7.
    发明申请
    SYSTEMS AND METHODS FOR BIOLOGICAL DATA MANAGEMENT 审中-公开

    公开(公告)号：US20190304571A1

    公开(公告)日：2019-10-03

    申请号：US16156755

    申请日：2018-10-10

    Applicant: Quantum Biosystems Inc.

    Inventor： Masoud Vakili ,  Kurt Christofferson ,  Mark Oldham

    IPC: G16B50/30 ,  G16B50/40 ,  G06F17/18

    Abstract: Systems and methods for biological data management may preserve alternative interpretations of data and may implement multi-level encryption and privacy management. Systems and methods for biological data management may include a cell-level architecture, a bank-and-bloc-level architecture, and/or a multi-tiered architecture. Systems and methods for biological data management may incorporate definitions, rules, and directives and/or employ a two-dimensional or three-dimensional data structure.

    NANOGAP ELECTRODE DEVICES AND SYSTEMS AND METHODS FOR FORMING THE SAME
    10.
    发明申请
    NANOGAP ELECTRODE DEVICES AND SYSTEMS AND METHODS FOR FORMING THE SAME 审中-公开

    公开(公告)号：US20170131237A1

    公开(公告)日：2017-05-11

    申请号：US15336515

    申请日：2016-10-27

    Applicant: Quantum Biosystems Inc.

    Inventor： Shuji Ikeda

    IPC: G01N27/447 ,  G01N33/487

    CPC classification number: G01N27/44791 ,  G01N33/48721

    Abstract: The present disclosure provides biopolymer detection devices and systems, and methods for forming such devices and systems. A device for detecting a biopolymer comprises a channel that is configured to direct the biopolymer and a pair of electrodes in a portion of the channel. The pair of electrodes has surfaces that are substantially coplanar with adjacent surfaces of the channel. Surfaces of the pair of electrodes are exposed during use of the device to enable detection the biopolymer or a portion thereof with the aid of the pair of electrodes.

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