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1.发明申请公开(公告)号：US20110195964A1
公开(公告)日：2011-08-11
申请号：US13125329
申请日：2009-10-19
申请人： Qun Dang , De Michael Chung , Tony S. Gibson , Daniel K. Cashion , HongJian Jiang , Jianming Bao , Ping Lan , Huagang Lu , Gergely M. Makara , F. Anthony Romero , Iyassu Sebhat , Dariusz Wodka
发明人： Qun Dang , De Michael Chung , Tony S. Gibson , Daniel K. Cashion , HongJian Jiang , Jianming Bao , Ping Lan , Huagang Lu , Gergely M. Makara , F. Anthony Romero , Iyassu Sebhat , Dariusz Wodka
IPC分类号： A61K31/5377 , C07D235/28 , A61K31/4184 , A61P3/10 , A61P3/04 , A61P3/06 , A61P35/00 , A61P9/12 , C07D405/10 , C07D401/10 , A61K31/4439 , A61K31/454 , C07D413/10 , C07D403/10 , A61K31/497
CPC分类号： C07D235/28 , C07D235/26 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D409/06 , C07D417/04
摘要： Novel compounds of the structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.
摘要翻译： 结构式（I）的新型化合物是AMP-蛋白激酶的活化剂，可用于治疗，预防和抑制AMPK活化蛋白激酶介导的疾病。 本发明的化合物可用于治疗2型糖尿病，高血糖症，代谢综合征，肥胖，高胆固醇血症和高血压。
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公开(公告)号：US08563746B2
公开(公告)日：2013-10-22
申请号：US13125329
申请日：2009-10-19
申请人： Qun Dang , De Michael Chung , Tony S. Gibson , Hongjian Jiang , Daniel K. Cashion , Jianming Bao , Ping Lan , Huagang Lu , Gergely M. Makara , F. Anthony Romero , Iyassu Sebhat , Dariusz Wodka
发明人： Qun Dang , De Michael Chung , Tony S. Gibson , Hongjian Jiang , Daniel K. Cashion , Jianming Bao , Ping Lan , Huagang Lu , Gergely M. Makara , F. Anthony Romero , Iyassu Sebhat , Dariusz Wodka
IPC分类号： A61K31/4184 , A61K31/5377 , A61K31/497 , C07D235/26 , C07D235/28 , C07D401/10 , C07D401/06 , C07D409/04 , C07D403/10 , C07D413/10 , C07D413/14 , C07D417/04
CPC分类号： C07D235/28 , C07D235/26 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D409/06 , C07D417/04
摘要： Novel compounds of the structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.
摘要翻译： 结构式（I）的新型化合物是AMP-蛋白激酶的活化剂，可用于治疗，预防和抑制AMPK活化蛋白激酶介导的疾病。 本发明的化合物可用于治疗2型糖尿病，高血糖症，代谢综合征，肥胖症，高胆固醇血症和高血压。
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公开(公告)号：US08329914B2
公开(公告)日：2012-12-11
申请号：US13125345
申请日：2009-10-22
申请人： Jianming Bao , Ping Lan , Huagang Lu , Gergely M. Makara , F. Anthony Romero , Iyassu Sebhat , Dariusz Wodka , Qun Dang , De Michael Chung , Tony S. Gibson , Hongjian Jiang , Daniel K. Cashion
发明人： Jianming Bao , Ping Lan , Huagang Lu , Gergely M. Makara , F. Anthony Romero , Iyassu Sebhat , Dariusz Wodka , Qun Dang , De Michael Chung , Tony S. Gibson , Hongjian Jiang , Daniel K. Cashion
IPC分类号： A61K31/675 , A61K31/4184 , C07F9/06 , C07D235/06 , C07D235/24
CPC分类号： C07F9/65068 , A61K31/366 , A61K31/397 , A61K31/4184 , A61K31/4412 , A61K45/06 , C07F9/65583 , C07F9/65742 , A61K2300/00
摘要： Novel compounds of the structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.
摘要翻译： 结构式（I）的新型化合物是AMP-蛋白激酶的活化剂，可用于治疗，预防和抑制AMPK活化蛋白激酶介导的疾病。 本发明的化合物可用于治疗2型糖尿病，高血糖症，代谢综合征，肥胖症，高胆固醇血症和高血压。
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公开(公告)号：US20110218174A1
公开(公告)日：2011-09-08
申请号：US13125345
申请日：2009-10-22
申请人： Jianming Bao , Ping Lan , Huagang Lu , Gergely M. Makara , F. Anthony Romero , Iyassu Sebhat , Dariusz Wodka , Qun Dang , De Michael Chung , Tony S. Gibson , Hongjian Jiang , Daniel K. Cashion
发明人： Jianming Bao , Ping Lan , Huagang Lu , Gergely M. Makara , F. Anthony Romero , Iyassu Sebhat , Dariusz Wodka , Qun Dang , De Michael Chung , Tony S. Gibson , Hongjian Jiang , Daniel K. Cashion
IPC分类号： A61K31/675 , C07F9/6506 , C07F9/6533 , C07F9/6574 , A61P35/00 , A61P3/10 , A61P3/00 , A61P3/04 , A61P9/12 , A61P3/06
CPC分类号： C07F9/65068 , A61K31/366 , A61K31/397 , A61K31/4184 , A61K31/4412 , A61K45/06 , C07F9/65583 , C07F9/65742 , A61K2300/00
摘要： Novel compounds of the structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.
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