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公开(公告)号:US08563746B2
公开(公告)日:2013-10-22
申请号:US13125329
申请日:2009-10-19
申请人: Qun Dang , De Michael Chung , Tony S. Gibson , Hongjian Jiang , Daniel K. Cashion , Jianming Bao , Ping Lan , Huagang Lu , Gergely M. Makara , F. Anthony Romero , Iyassu Sebhat , Dariusz Wodka
发明人: Qun Dang , De Michael Chung , Tony S. Gibson , Hongjian Jiang , Daniel K. Cashion , Jianming Bao , Ping Lan , Huagang Lu , Gergely M. Makara , F. Anthony Romero , Iyassu Sebhat , Dariusz Wodka
IPC分类号: A61K31/4184 , A61K31/5377 , A61K31/497 , C07D235/26 , C07D235/28 , C07D401/10 , C07D401/06 , C07D409/04 , C07D403/10 , C07D413/10 , C07D413/14 , C07D417/04
CPC分类号: C07D235/28 , C07D235/26 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D409/06 , C07D417/04
摘要: Novel compounds of the structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.
摘要翻译: 结构式(I)的新型化合物是AMP-蛋白激酶的活化剂,可用于治疗,预防和抑制AMPK活化蛋白激酶介导的疾病。 本发明的化合物可用于治疗2型糖尿病,高血糖症,代谢综合征,肥胖症,高胆固醇血症和高血压。
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公开(公告)号:US08329914B2
公开(公告)日:2012-12-11
申请号:US13125345
申请日:2009-10-22
申请人: Jianming Bao , Ping Lan , Huagang Lu , Gergely M. Makara , F. Anthony Romero , Iyassu Sebhat , Dariusz Wodka , Qun Dang , De Michael Chung , Tony S. Gibson , Hongjian Jiang , Daniel K. Cashion
发明人: Jianming Bao , Ping Lan , Huagang Lu , Gergely M. Makara , F. Anthony Romero , Iyassu Sebhat , Dariusz Wodka , Qun Dang , De Michael Chung , Tony S. Gibson , Hongjian Jiang , Daniel K. Cashion
IPC分类号: A61K31/675 , A61K31/4184 , C07F9/06 , C07D235/06 , C07D235/24
CPC分类号: C07F9/65068 , A61K31/366 , A61K31/397 , A61K31/4184 , A61K31/4412 , A61K45/06 , C07F9/65583 , C07F9/65742 , A61K2300/00
摘要: Novel compounds of the structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.
摘要翻译: 结构式(I)的新型化合物是AMP-蛋白激酶的活化剂,可用于治疗,预防和抑制AMPK活化蛋白激酶介导的疾病。 本发明的化合物可用于治疗2型糖尿病,高血糖症,代谢综合征,肥胖症,高胆固醇血症和高血压。
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公开(公告)号:US20110218174A1
公开(公告)日:2011-09-08
申请号:US13125345
申请日:2009-10-22
申请人: Jianming Bao , Ping Lan , Huagang Lu , Gergely M. Makara , F. Anthony Romero , Iyassu Sebhat , Dariusz Wodka , Qun Dang , De Michael Chung , Tony S. Gibson , Hongjian Jiang , Daniel K. Cashion
发明人: Jianming Bao , Ping Lan , Huagang Lu , Gergely M. Makara , F. Anthony Romero , Iyassu Sebhat , Dariusz Wodka , Qun Dang , De Michael Chung , Tony S. Gibson , Hongjian Jiang , Daniel K. Cashion
IPC分类号: A61K31/675 , C07F9/6506 , C07F9/6533 , C07F9/6574 , A61P35/00 , A61P3/10 , A61P3/00 , A61P3/04 , A61P9/12 , A61P3/06
CPC分类号: C07F9/65068 , A61K31/366 , A61K31/397 , A61K31/4184 , A61K31/4412 , A61K45/06 , C07F9/65583 , C07F9/65742 , A61K2300/00
摘要: Novel compounds of the structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.
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公开(公告)号:US08394969B2
公开(公告)日:2013-03-12
申请号:US12563782
申请日:2009-09-21
申请人: Brett C. Bookser , Qun Dang , Tony S. Gibson , Hongjian Jiang , De Michael Chung , Jianming Bao , Jinlong Jiang , Andy Kassick , Ahmet Kekec , Ping Lan , Huagang Lu , Gergely M. Makara , F. Anthony Romero , Iyassu Sebhat , David Wilson , Dariusz Wodka
发明人: Brett C. Bookser , Qun Dang , Tony S. Gibson , Hongjian Jiang , De Michael Chung , Jianming Bao , Jinlong Jiang , Andy Kassick , Ahmet Kekec , Ping Lan , Huagang Lu , Gergely M. Makara , F. Anthony Romero , Iyassu Sebhat , David Wilson , Dariusz Wodka
IPC分类号: A61K31/4184 , C07D235/26 , C07D235/28 , C07D235/30
CPC分类号: C07D235/26 , C07D235/28 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12
摘要: Novel compounds of the structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.
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5.
公开(公告)号:US20100081643A1
公开(公告)日:2010-04-01
申请号:US12563782
申请日:2009-09-21
申请人: BRETT C. BOOKSER , Qun Dang , Tony S. Gibson , Hongjian Jiang , De Michael Chung , Jianming Bao , Jinlong Jiang , Andy Kassick , Ahmet Kekec , Ping Lan , Huagang Lu , Gergely M. Makara , F. Anthony Romero , Iyassu Sebhat , David Wilson , Dariusz Wodka
发明人: BRETT C. BOOKSER , Qun Dang , Tony S. Gibson , Hongjian Jiang , De Michael Chung , Jianming Bao , Jinlong Jiang , Andy Kassick , Ahmet Kekec , Ping Lan , Huagang Lu , Gergely M. Makara , F. Anthony Romero , Iyassu Sebhat , David Wilson , Dariusz Wodka
IPC分类号: A61K31/4184 , C07D235/26 , C07D403/12 , C07D401/12 , C07D413/10 , A61K31/397 , A61K31/44 , A61K31/5025 , A61K31/4439 , A61P3/00 , A61P9/00
CPC分类号: C07D235/26 , C07D235/28 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12
摘要: Novel compounds of the structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.
摘要翻译: 结构式(I)的新型化合物是AMP-蛋白激酶的活化剂,可用于治疗,预防和抑制AMPK活化蛋白激酶介导的疾病。 本发明的化合物可用于治疗2型糖尿病,高血糖症,代谢综合征,肥胖症,高胆固醇血症和高血压。
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公开(公告)号:US08410284B2
公开(公告)日:2013-04-02
申请号:US13124898
申请日:2009-10-12
申请人: Qun Dang , Tony S. Gibson , Hongjian Jiang , De Michael Chung , Jianming Bao , Jinlong Jiang , Andy Kassick , Ahmet Kekec , Ping Lan , Huagang Lu , Gergely M. Makara , F. Anthony Romero , Iyassu Sebhat , David Wilson , Dariusz Wodka , Brett C. Bookser
发明人: Qun Dang , Tony S. Gibson , Hongjian Jiang , De Michael Chung , Jianming Bao , Jinlong Jiang , Andy Kassick , Ahmet Kekec , Ping Lan , Huagang Lu , Gergely M. Makara , F. Anthony Romero , Iyassu Sebhat , David Wilson , Dariusz Wodka , Brett C. Bookser
IPC分类号: A61K31/675 , C07F9/00 , C07F9/6506
CPC分类号: C07F9/65068 , C07F9/65583 , C07F9/657181
摘要: Novel compounds of the structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, Metabolic Syndrome, obesity, hypercholesterolemia, and hypertension.
摘要翻译: 结构式(I)的新型化合物是AMP-蛋白激酶的活化剂,可用于治疗,预防和抑制AMPK活化蛋白激酶介导的疾病。 本发明的化合物可用于治疗2型糖尿病,高血糖症,代谢综合征,肥胖,高胆固醇血症和高血压。
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7.
公开(公告)号:US20110263533A1
公开(公告)日:2011-10-27
申请号:US13124898
申请日:2009-10-12
申请人: Qun Dang , Tony S. Gibson , Hongjian Jiang , De Michael Chung , Jianming Bao , Jinlong Jiang , Andy Kassick , Ahmet Kekec , Ping Lan , Huagang Lu , Gergely M. Makara , F. Anthony Romero , Iyassu Sebhat , David Wilson , Dariusz Wodka , Brett C. Bookser
发明人: Qun Dang , Tony S. Gibson , Hongjian Jiang , De Michael Chung , Jianming Bao , Jinlong Jiang , Andy Kassick , Ahmet Kekec , Ping Lan , Huagang Lu , Gergely M. Makara , F. Anthony Romero , Iyassu Sebhat , David Wilson , Dariusz Wodka , Brett C. Bookser
IPC分类号: A61K31/675 , C07F9/40 , C07F9/6574 , A61P35/00 , A61P3/04 , A61P3/06 , A61P9/12 , C07F9/6506 , A61P3/10
CPC分类号: C07F9/65068 , C07F9/65583 , C07F9/657181
摘要: Novel compounds of the structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, Metabolic Syndrome, obesity, hypercholesterolemia, and hypertension.
摘要翻译: 结构式(I)的新型化合物是AMP-蛋白激酶的活化剂,可用于治疗,预防和抑制AMPK活化蛋白激酶介导的疾病。 本发明的化合物可用于治疗2型糖尿病,高血糖症,代谢综合征,肥胖,高胆固醇血症和高血压。
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公开(公告)号:US20100081634A1
公开(公告)日:2010-04-01
申请号:US11816774
申请日:2006-05-26
申请人: Mark D. Erion , Hongjian Jiang , Serge H. Boyer
发明人: Mark D. Erion , Hongjian Jiang , Serge H. Boyer
IPC分类号: A61K31/675 , A61K31/66 , C07F9/28 , C07F9/02
CPC分类号: C07F9/4056 , C07F9/301 , C07F9/306 , C07F9/3808 , C07F9/3882 , C07F9/4006 , C07F9/4075 , C07F9/4407 , C07F9/4465 , C07F9/5728 , C07F9/58 , C07F9/65517 , C07F9/657181
摘要: The present invention relates to compounds of phosphonic acid-containing T3 mimetics and monoesters thereof, stereoisomers, pharmaceutically acceptable salts, co-crystals, and prodrugs thereof and pharmaceutically acceptable salts and co-crystals of the prodrugs, as well as their preparation and uses for preventing and/or treating metabolic diseases such as obesity, NASH, hypercholesterolemia and hyperlipidemia, as well as associated conditions such as atherosclerosis, coronary heart disease, impaired glucose tolerance, metabolic syndrome x and diabetes.
摘要翻译: 本发明涉及含膦酸的T3模拟物及其单酯的化合物,其立体异构体,药学上可接受的盐,共晶体和前药以及其药学上可接受的盐和共结晶,以及它们的制备和用途 预防和/或治疗诸如肥胖,NASH,高胆固醇血症和高脂血症的代谢疾病,以及相关病症如动脉粥样硬化,冠心病,葡萄糖耐量降低,代谢综合症x和糖尿病。
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公开(公告)号:US20090118236A1
公开(公告)日:2009-05-07
申请号:US10580134
申请日:2004-11-19
申请人: Mark D. Erion , Hongjian Jiang , Serge H. Boyer
发明人: Mark D. Erion , Hongjian Jiang , Serge H. Boyer
IPC分类号: A61K31/675 , C07F9/6571 , A61K31/662 , C07F9/59 , A61P5/14 , A61P3/00 , G01N33/566 , C07F9/58 , C07F9/38
CPC分类号: C07F9/4056 , C07F9/301 , C07F9/306 , C07F9/3808 , C07F9/3882 , C07F9/4006 , C07F9/4075 , C07F9/4407 , C07F9/4465 , C07F9/5728 , C07F9/58 , C07F9/65517 , C07F9/657181
摘要: The present invention relates to compounds of phosphonic acid containing T3 mimetics, stereoisomers, pharmaceutically acceptable salts, co-crystals, and prodrugs thereof and pharmaceutically acceptable salts and co-crystals of the prodrugs, as well as their preparation and uses for preventing and/or treating metabolic diseases such as obesity, NASH, hypercholesterolemia and hyperlipidemia, as well as associated conditions such as atherosclerosis, coronary heart disease, impaired glucose tolerance, metabolic syndromex and diabetes.
摘要翻译: 本发明涉及含有T3模拟物的膦酸化合物,其立体异构体,药学上可接受的盐,共晶体和前体药物以及前体药学上可接受的盐和共晶体,以及它们的制备和用途,用于预防和/或 治疗代谢疾病如肥胖,NASH,高胆固醇血症和高脂血症,以及相关病症如动脉粥样硬化,冠心病,糖耐量异常,代谢综合征和糖尿病。
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公开(公告)号:US20190321379A1
公开(公告)日:2019-10-24
申请号:US16095228
申请日:2017-04-24
发明人: Brian Lian , Rochelle Hanley , Misha Dinerman , Mark Erion , Serge Boyer , Hongjian Jiang
IPC分类号: A61K31/662
摘要: Methods useful for treating X-linked adrenoleukodystrophy are provided.
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