公开(公告)号：US20110236890A1

公开(公告)日：2011-09-29

申请号：US12738665

申请日：2008-11-19

申请人： Qun Lu ,  Tao Wang ,  Yan-Hua Chen

发明人： Qun Lu ,  Tao Wang ,  Yan-Hua Chen

IPC分类号： C12Q1/68

CPC分类号： C07K14/4702 ,  C12Q1/6886 ,  C12Q2600/16

摘要： A method for screening for risk of cancer in a subject is carried out by detecting the presence or absence of at least one mutation in the delta-catenin gene promoter or 5′ untranslated region in a biological sample from said subject, the presence of such mutation or an increased frequency of mutation indicating said subject is afflicted with or at least at risk of developing cancer.

摘要翻译： 通过检测来自所述受试者的生物样品中δ-连环蛋白基因启动子或5'非翻译区中至少一个突变的存在或不存在，进行受试者中癌症风险筛选的方法，这种突变的存在 或指示所述受试者的突变频率增加或至少具有发展为癌症的风险。

公开(公告)号：US08932824B2

公开(公告)日：2015-01-13

申请号：US13251481

申请日：2011-10-03

申请人： Qun Lu ,  Yan-hua Chen

发明人： Qun Lu ,  Yan-hua Chen

IPC分类号： G01N33/574

CPC分类号： G01N33/57415 ,  C12Q1/6886 ,  G01N33/574 ,  G01N33/57434

摘要： The present invention provides a method for detecting or screening for the presence of cancer in a subject. The method comprises obtaining, providing or collecting a tissue or fluid sample (such as a urine sample) from said subject, and then determining the presence or absence of delta-catenin in said sample, or increased levels of delta-catenin in said sample as compared to a normal or control subject. The presence of delta-catenin in said sample, or increased levels of delta-catenin in said sample, indicating said subject is afflicted with or at least at risk of developing cancer.

摘要翻译： 本发明提供了用于检测或筛选受试者中癌症存在的方法。 该方法包括从所述受试者获得，提供或收集组织或流体样品（例如尿液样品），然后确定所述样品中δ-连环蛋白的存在或不存在，或所述样品中δ-连环蛋白的增加水平为 与正常或对照对象相比。 所述样品中δ-连环蛋白的存在或所述样品中δ-连环蛋白的水平升高，表明所述受试者患有或至少具有发展为癌症的风险。

公开(公告)号：US20140051081A1

公开(公告)日：2014-02-20

申请号：US14007744

申请日：2012-03-29

申请人： Qun Lu ,  Yan-Hua Chen

发明人： Qun Lu ,  Yan-Hua Chen

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/156

摘要： Aspects of the present invention provide methods such as screening for risk of cancer, detecting cancer and/or determining treatment for cancer in a subject including detecting the presence or absence of at least one mutation in the delta-catenin coding region. Aspects of the present invention also provide kits for carrying out the methods described herein.

摘要翻译： 本发明的方面提供了筛选癌症风险，检测癌症和/或确定受试者癌症治疗的方法，包括检测δ-连环蛋白编码区中是否存在至少一个突变。 本发明的方面还提供用于实施本文所述方法的试剂盒。

公开(公告)号：US08058020B2

公开(公告)日：2011-11-15

申请号：US12238539

申请日：2008-09-26

申请人： Qun Lu ,  Yan-hua Chen

发明人： Qun Lu ,  Yan-hua Chen

IPC分类号： C12Q1/00 ,  G01N33/574

CPC分类号： G01N33/57415 ,  C12Q1/6886 ,  G01N33/574 ,  G01N33/57434

摘要： The present invention provides a method for detecting or screening for the presence of cancer in a subject. The method comprises obtaining, providing or collecting a tissue or fluid sample (such as a urine sample) from said subject, and then determining the presence or absence of delta-catenin in said sample, or increased levels of delta-catenin in said sample as compared to a normal or control subject. The presence of delta-catenin in said sample, or increased levels of delta-catenin in said sample, indicating said subject is afflicted with or at least at risk of developing cancer.

摘要翻译： 本发明提供了用于检测或筛选受试者中癌症存在的方法。 该方法包括从所述受试者获得，提供或收集组织或流体样品（例如尿液样品），然后确定所述样品中δ-连环蛋白的存在或不存在，或所述样品中δ-连环蛋白的增加水平为 与正常或对照对象相比。 所述样品中δ-连环蛋白的存在或所述样品中δ-连环蛋白的水平升高，表明所述受试者患有或至少具有发展为癌症的风险。

公开(公告)号：US20090136943A1

公开(公告)日：2009-05-28

申请号：US12238539

申请日：2008-09-26

申请人： Qun Lu ,  Yan-hua Chen

发明人： Qun Lu ,  Yan-hua Chen

IPC分类号： C12Q1/68

CPC分类号： G01N33/57415 ,  C12Q1/6886 ,  G01N33/574 ,  G01N33/57434

摘要： The present invention provides a method for detecting or screening for the presence of cancer in a subject. The method comprises obtaining, providing or collecting a tissue or fluid sample (such as a urine sample) from said subject, and then determining the presence or absence of delta-catenin in said sample, or increased levels of delta-catenin in said sample as compared to a normal or control subject. The presence of delta-catenin in said sample, or increased levels of delta-catenin in said sample, indicating said subject is afflicted with or at least at risk of developing cancer.

摘要翻译： 本发明提供了用于检测或筛选受试者中癌症存在的方法。 该方法包括从所述受试者获得，提供或收集组织或流体样品（例如尿液样品），然后确定所述样品中δ-连环蛋白的存在或不存在，或所述样品中δ-连环蛋白的增加水平为 与正常或对照对象相比。 所述样品中δ-连环蛋白的存在或所述样品中δ-连环蛋白的水平升高，表明所述受试者患有或至少具有发展为癌症的风险。

公开(公告)号：US07445906B2

公开(公告)日：2008-11-04

申请号：US10872692

申请日：2004-06-21

申请人： Qun Lu ,  Yan-hua Chen

发明人： Qun Lu ,  Yan-hua Chen

IPC分类号： G01N33/574 ,  G01N33/53 ,  C12Q1/00

CPC分类号： G01N33/57415 ,  C12Q1/6886 ,  G01N33/574 ,  G01N33/57434

摘要： The present invention provides a method for detecting or screening for the presence of cancer in a subject. The method comprises obtaining, providing or collecting a tissue or fluid sample (such as a urine sample) from said subject, and then determining the presence or absence of delta-catenin in said sample, or increased levels of delta-catenin in said sample as compared to a normal or control subject. The presence of delta-catentin in said sample, or increased levels of delta-catenin in said sample, indicating said subject is afflicted with or at least at risk of developing cancer.

摘要翻译： 本发明提供了用于检测或筛选受试者中癌症存在的方法。 该方法包括从所述受试者获得，提供或收集组织或流体样品（例如尿液样品），然后确定所述样品中δ-连环蛋白的存在或不存在，或所述样品中δ-连环蛋白的增加水平为 与正常或对照对象相比。 所述样品中δ-卡汀的存在或所述样品中δ-连环蛋白的水平升高，表明所述受试者患有或至少具有发生癌症的风险。

公开(公告)号：US20050032099A1

公开(公告)日：2005-02-10

申请号：US10872692

申请日：2004-06-21

申请人： Qun Lu ,  Yan-hua Chen

发明人： Qun Lu ,  Yan-hua Chen

IPC分类号： C12Q1/68 ,  G01N20060101 ,  G01N33/53 ,  G01N33/567 ,  G01N33/574

CPC分类号： G01N33/57415 ,  C12Q1/6886 ,  G01N33/574 ,  G01N33/57434

摘要： The present invention provides a method for detecting or screening for the presence of cancer in a subject. The method comprises obtaining, providing or collecting a tissue or fluid sample (such as a urine sample) from said subject, and then determining the presence or absence of delta-catenin in said sample, or increased levels of delta-catenin in said sample as compared to a normal or control subject. The presence of delta-catentin in said sample, or increased levels of delta-ctanin in said sample, indicating said subject is afflicted with or at least at risk of developing cancer.

摘要翻译： 本发明提供了用于检测或筛选受试者中癌症存在的方法。 该方法包括从所述受试者获得，提供或收集组织或流体样品（例如尿液样品），然后确定所述样品中δ-连环蛋白的存在或不存在，或所述样品中δ-连环蛋白的增加水平为 与正常或对照对象相比。 所述样品中δ-卡汀的存在或所述样品中δ-角质层的增加，表明所述受试者患有或至少具有发展为癌症的风险。

公开(公告)号：US20120100998A1

公开(公告)日：2012-04-26

申请号：US13251481

申请日：2011-10-03

申请人： Qun Lu ,  Yan-hua Chen

发明人： Qun Lu ,  Yan-hua Chen

IPC分类号： G01N33/574 ,  C40B30/00 ,  C12Q1/68

CPC分类号： G01N33/57415 ,  C12Q1/6886 ,  G01N33/574 ,  G01N33/57434

摘要： The present invention provides a method for detecting or screening for the presence of cancer in a subject. The method comprises obtaining, providing or collecting a tissue or fluid sample (such as a urine sample) from said subject, and then determining the presence or absence of delta-catenin in said sample, or increased levels of delta-catenin in said sample as compared to a normal or control subject. The presence of delta-catenin in said sample, or increased levels of delta-catenin in said sample, indicating said subject is afflicted with or at least at risk of developing cancer.

摘要翻译： 本发明提供了用于检测或筛选受试者中癌症存在的方法。 该方法包括从所述受试者获得，提供或收集组织或流体样品（例如尿液样品），然后确定所述样品中δ-连环蛋白的存在或不存在，或所述样品中δ-连环蛋白的增加水平为 与正常或对照对象相比。 所述样品中δ-连环蛋白的存在或所述样品中δ-连环蛋白的水平升高，表明所述受试者患有或至少具有发展为癌症的风险。

公开(公告)号：US11439608B2

公开(公告)日：2022-09-13

申请号：US16141849

申请日：2018-09-25

申请人： Qun Lu

发明人： Qun Lu ,  Byron Aguilar ,  Yi Zhu ,  Yan-Hua Chen

IPC分类号： A61K31/18 ,  A61K31/166 ,  A61K31/343 ,  A61K31/505 ,  A61P25/28

摘要： Methods of treating Alzheimer's disease and other neurodegenerative and/or neurocognitive and/or neurodevelopmental diseases are described. The methods comprise the administration of compounds that modulate an activity of cell division control protein 42 (Cdc42), such as the interaction between Cdc42 and intersectin (ITSN). Exemplary modulator compounds include thioureas, disulfonamides of fused aromatic systems (e.g., benzofuran), and acyl hydrazones, among others. Some of the modulator compounds act as activators of Cdc42, while others act as inhibitors. In some cases, the modulator compound has dual functionality and the ability of the modulator compound to act as an inhibitor or activator depends on whether or not Cdc42 is already activated in a particular disease stage or biological environment by an upstream activating signal of Cdc42.

公开(公告)号：US10085991B2

公开(公告)日：2018-10-02

申请号：US15532721

申请日：2015-12-01

申请人： Merck Sharp & Dohme Corp. ,  Lei Zhu ,  Yvonne Cegielnik ,  Qun Lu

发明人： Lei Zhu ,  Yvonne Cegielnik ,  Qun Lu

IPC分类号： A61K31/52 ,  A61K9/00 ,  A61K47/26 ,  A61K47/02 ,  A61K47/20 ,  A61K47/12 ,  A61K47/32 ,  A61K9/10 ,  A61K47/38

摘要： The present invention is directed to formulations comprising PVP polymer, a dispersion of a compound of Formula I (API), and citric acid, which formulations mitigate the effects of coadministering the compound of Formula I with a proton pump inhibitor compound.