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公开(公告)号：US6093805A
公开(公告)日：2000-07-25
申请号：US915699
申请日：1997-08-21
CPC分类号： C07H15/18 , C07H15/256 , C07H17/04 , C07J17/005 , C07J9/00 , C07J9/005
摘要： Novel glycosides, especially steroidal and non-steroidal glycosides are provided. The steroidal and non-steroidal glycosides preferably are prepared from aglycons which possess valuable properties such as pharmacological properties. The glycosides are prepared from useful aglycons and possess useful properties which are the same as those of their respective unglycosylated aglycons. The glycosides are provided in acylated and deacylated form. The acylated glycosides after hydrolysis of the acyl groups possess enhanced water solubility properties, as illustrated in the case where the aglycon is acetominophen.
摘要翻译： 提供新的糖苷，特别是甾体和非甾体糖苷。 甾体和非甾体糖苷优选由具有有价值性质如药理学性质的糖苷配制剂制备。 糖苷由有用的糖苷配制而成，具有与它们各自的未糖基化糖苷基相同的有用性质。 糖苷以酰化和脱酰基形式提供。 酰基水解后的酰化糖苷具有增强的水溶性，如糖苷配基是乙酰氨基酚的情况所示。
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公开(公告)号：US5693767A
公开(公告)日：1997-12-02
申请号：US251869
申请日：1994-06-01
CPC分类号： C07H15/18 , C07H15/256 , C07H17/04 , C07J17/005 , C07J9/00 , C07J9/005
摘要： Novel glycosides, especially steroidal and non-steroidal glycosides are provided. The steroidal and non-steroidal glycosides preferably are prepared from aglycons which possess valuable properties such as pharmacological properties. The glycosides are prepared from useful aglycons and possess useful properties which are the same as those of their respective unglycosylated aglycons. The glycosides are provided in acylated and deacylated form. The acylated glycosides after hydrolysis of the acyl groups possess enhanced water solubility properties, as illustrated in the case where the aglycon is acetominophen.
摘要翻译： 提供新的糖苷，特别是甾体和非甾体糖苷。 甾体和非甾体糖苷优选由具有有价值性质如药理学性质的糖苷配制剂制备。 糖苷由有用的糖苷配制而成，具有与它们各自的未糖基化糖苷基相同的有用性质。 糖苷以酰化和脱酰基形式提供。 酰基水解后的酰化糖苷具有增强的水溶性，如糖苷配基是乙酰氨基酚的情况所示。
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3.发明授权Synthesis of C-glycosylated compounds with the use of a mild, iodine-catalyzed reaction 失效使用温和的碘催化反应合成C-糖基化化合物
公开(公告)号：US5414074A
公开(公告)日：1995-05-09
申请号：US951529
申请日：1992-09-25
申请人： Masato Koreeda , Todd A. Houston
发明人： Masato Koreeda , Todd A. Houston
IPC分类号： C07D307/32 , C07D309/30 , C07H1/00 , C07G3/00 , C07H15/04
CPC分类号： C07D307/32 , C07D309/30
摘要： The invention concerns C-glycosylated derivatives of soft carbon nucleophile compounds, particularly compounds which contain acid-labile structural units. The invention further concerns a mild, cost-effective, non-hazardous and stereoselective method of general application employing a glycal as a glycosyulating agent and iodine as a catalyst for the preparation of C-glycosylated soft carbon nucleophile compounds.
摘要翻译： 本发明涉及软碳亲核试剂化合物的C-糖基化衍生物，特别是含酸不稳定结构单元的化合物。 本发明还涉及使用甘氨酸作为糖基化剂和碘作为制备C-糖基化的软碳亲核化合物的催化剂的温和的，具有成本效益的，无危害的和立体选择性的一般应用方法。
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