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    Treatment of bacterial infections
    2.
    发明授权
    Treatment of bacterial infections 失效
    细菌感染的治疗

    公开(公告)号：US06310043B1

    公开(公告)日：2001-10-30

    申请号：US09317290

    申请日：1999-05-24

    申请人： David R. Bundle ,  Pavel Kitov ,  Randy J. Read ,  Hong Ling ,  Glen Armstrong

    发明人： David R. Bundle ,  Pavel Kitov ,  Randy J. Read ,  Hong Ling ,  Glen Armstrong

    IPC分类号： A61K3170

    CPC分类号： C07H15/04 ,  A61K47/549 ,  A61K47/59 ,  C07H3/04 ,  C07H3/06 ,  Y10S424/16

    摘要： Compounds which bind to toxins associated with enteric bacterial infection, compositions including the compounds, methods for the neutralization of toxins in a patient, and methods for the diagnosis of bacterial and viral infections are disclosed. Toxins which can be bound by the compounds include pentameric toxins, for example SLTs, such as those from salmonella, camylobacter and other bacteria, verotoxins from E. coli, cholera toxin, clostridium difficile toxins A and B, bacterial pili from enteropathogenic E. coli (EPEC) and enterotoxigenic E. coli (ETEC) and viral lectins such as viral hemagglutinins. The compounds include a core molecule bound to a plurality of linker arms, which in turn are bound to a plurality of bridging moieties, which in turn are bound to at least one, and preferably, two or more ligands which bind to the toxin. The presence of a plurality of bridged dimers of the ligands is responsible for the increased binding affinity of the compounds relative to the ligands themselves. In one embodiment, the compounds, when administered in a timely fashion to a patient suffering from enteric E. coli infection, inhibit progression of this infection into hemolytic uremic syndrome (HUS).

    摘要翻译： 公开了结合与肠细菌感染相关的毒素的化合物，包括该化合物的组合物，用于中和患者中的毒素的方法，以及诊断细菌和病毒感染的方法。 可以被化合物结合的毒素包括五聚体毒素，例如SLT，例如来自沙门氏菌属，弯孢杆菌属和其他细菌的那些，来自大肠杆菌的肠毒素，霍乱毒素，艰难梭菌毒素A和B，来自肠致病性大肠杆菌的细菌 （EPEC）和肠毒素性大肠杆菌（ETEC）和病毒凝集素如病毒血凝素。 化合物包括与多个连接臂结合的核心分子，其又结合到多个桥连部分，其又结合至少一个，优选两个或更多个与毒素结合的配体。 配体的多个桥连二聚体的存在导致化合物相对于配体本身的增加的结合亲和力。 在一个实施方案中，当及时给予患有肠道大肠杆菌感染的患者时，化合物抑制该感染进入溶血性尿毒综合征（HUS）。

    Treatment of bacterial dysentery
    3.
    发明授权
    Treatment of bacterial dysentery 失效
    治疗细菌性痢疾

    公开(公告)号：US5962423A

    公开(公告)日：1999-10-05

    申请号：US130495

    申请日：1998-08-07

    申请人： David R. Bundle ,  Pavel Kitov ,  Randy J. Read ,  Hong Ling ,  Glen Armstrong

    发明人： David R. Bundle ,  Pavel Kitov ,  Randy J. Read ,  Hong Ling ,  Glen Armstrong

    IPC分类号： A61K47/48 ,  C07H3/04 ,  C07H3/06 ,  A61K31/70 ,  A61K31/74 ,  A61K31/745 ,  A61K31/785

    CPC分类号： C07H3/06 ,  A61K47/48192 ,  C07H3/04 ,  Y10S424/16

    摘要： Compounds which bind to shiga-like toxins (SLT) associated with enteric E. coli infection, compositions including the compounds, methods for the neutralization of (SLT) in a patient, and methods for the diagnosis of enteric E. coli infection are disclosed. The compounds include a core molecule bound to a plurality of linker arms, which in turn are bound to a plurality of bridging moieties, which in turn are bound to two or three di- or tri-saccharide moieties. The di- or tri-saccharide moieties themselves are active in binding to the SLTs. The presence of a plurality of bridged dimers of the di- and tri-saccharides is responsible for the increased binding affinity of the compounds relative to the di- and tri-saccharides themselves. The compounds, when administered in a timely fashion to a patient suffering from enteric E. coli infection, inhibit progression of this infection into hemolytic uremic syndrome (HUS).

    摘要翻译： 公开了结合与肠道大肠杆菌感染相关的志贺样毒素（SLT）的化合物，包括该化合物的组合物，患者中的（SLT）的方法以及肠道大肠杆菌感染的诊断方法。 化合物包括与多个连接臂结合的核心分子，其又结合到多个桥连部分，其又结合到两个或三个二糖或三糖部分上。 二糖或三糖部分本身具有活性的结合SLT。 二糖和三糖的多个桥连二聚体的存在导致化合物相对于二糖和三糖本身增加的结合亲和力。 当及时给予患有肠道大肠杆菌感染的患者时，这些化合物抑制该感染进入溶血性尿毒症综合征（HUS）。