公开(公告)号：US20130060105A1

公开(公告)日：2013-03-07

申请号：US13478420

申请日：2012-05-23

申请人： RAJIV SHAH ,  JESPER SVENNING KRISTENSEN ,  KATHERINE T. WOLFE ,  SOREN AASMUL ,  ANUBHUTI BANSAL

发明人： RAJIV SHAH ,  JESPER SVENNING KRISTENSEN ,  KATHERINE T. WOLFE ,  SOREN AASMUL ,  ANUBHUTI BANSAL

IPC分类号： A61B5/1477 ,  A61B5/1473 ,  A61B5/1459 ,  A61B5/1455

CPC分类号： A61B5/14532 ,  A61B5/0002 ,  A61B5/0004 ,  A61B5/14556 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/4839 ,  A61B5/6848 ,  A61B5/6849 ,  A61B5/742 ,  A61M5/1723 ,  A61M2230/201 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/7703 ,  G01N33/66 ,  G01N2021/6441 ,  G01N2021/6484 ,  G01N2021/772 ,  G01N2021/7733 ,  G01N2021/775 ,  G01N2021/7759 ,  G01N2021/7786 ,  G01N2333/4724

摘要： A continuous glucose monitoring system may include a hand-held monitor, a transmitter, an insulin pump, and an orthogonally redundant glucose sensor, which may comprise an optical glucose sensor and a non-optical glucose sensor. The former may be a fiber optical sensor, including a competitive glucose binding affinity assay with a glucose analog and a fluorophore-labeled glucose receptor, which is interrogated by an optical interrogating system, e.g., a stacked planar integrated optical system. The non-optical sensor may be an electrochemical sensor having a plurality of electrodes distributed along the length thereof. Proximal portions of the optical and electrochemical sensors may be housed inside the transmitter and operationally coupled with instrumentation for, e.g., receiving signals from the sensors, converting to respective glucose values, and communicating the glucose values. The sensors' distal portions may be inserted into a user's body via a single delivery needle and may be co-located inside the user's body.

摘要翻译： 连续葡萄糖监测系统可以包括手持监视器，发射器，胰岛素泵和正交冗余葡萄糖传感器，其可以包括光学葡萄糖传感器和非光学葡萄糖传感器。 前者可以是纤维光学传感器，其包括具有葡萄糖类似物和荧光团标记的葡萄糖受体的竞争性葡萄糖结合亲和力测定，其通过光学询问系统例如堆叠的平面集成光学系统进行询问。 非光学传感器可以是具有沿其长度分布的多个电极的电化学传感器。 光学和电化学传感器的近端部分可以容纳在发射器内部并且可操作地与仪器耦合，以便例如从传感器接收信号，转换成相应的葡萄糖值并传达葡萄糖值。 传感器的远端部分可以经由单个输送针插入使用者的身体，并且可以位于使用者的身体内。