公开(公告)号：US20140356439A1

公开(公告)日：2014-12-04

申请号：US14459569

申请日：2014-08-14

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Rimona MARGALIT ,  Dan PEER

IPC: A61K9/50 ,  A61K31/704 ,  A61K31/407 ,  A61K45/06 ,  A61K38/38 ,  A61K38/28 ,  A61K38/21 ,  A61K31/711 ,  A61K31/196 ,  A61K31/165

CPC classification number: A61K9/5052 ,  A61K9/1629 ,  A61K9/1658 ,  A61K9/5089 ,  A61K31/14 ,  A61K31/165 ,  A61K31/196 ,  A61K31/351 ,  A61K31/407 ,  A61K31/704 ,  A61K31/7088 ,  A61K31/711 ,  A61K38/212 ,  A61K38/28 ,  A61K38/385 ,  A61K45/06 ,  A61K47/545 ,  A61K48/0008 ,  A61K49/0002 ,  A61K49/0043 ,  A61K51/08 ,  A61K51/1265

Abstract: Lipidated micro- or macroparticles are prepared by covalently linking a glycoprotein, typically collagen, with at least one lipid. An amino group in the glycoprotein is joined with a primary amine in the lipid. These particles can be used to encapsulate active ingredients, such as drugs.

Abstract translation: 通过将糖蛋白（通常为胶原）与至少一种脂质共价连接来制备脂质化的微粒或大颗粒。 糖蛋白中的氨基与脂质中的伯胺结合。 这些颗粒可用于包封活性成分，如药物。

公开(公告)号：US20160354318A1

公开(公告)日：2016-12-08

申请号：US15228449

申请日：2016-08-04

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Rimona MARGALIT ,  Dan PEER

IPC: A61K9/50 ,  A61K51/12 ,  A61K51/08 ,  A61K48/00 ,  A61K31/14 ,  A61K38/38 ,  A61K31/407 ,  A61K47/48 ,  A61K38/21 ,  A61K31/7088 ,  A61K38/28 ,  A61K49/00 ,  A61K31/351

CPC classification number: A61K9/5052 ,  A61K9/1629 ,  A61K9/1658 ,  A61K9/5089 ,  A61K31/14 ,  A61K31/165 ,  A61K31/196 ,  A61K31/351 ,  A61K31/407 ,  A61K31/704 ,  A61K31/7088 ,  A61K31/711 ,  A61K38/212 ,  A61K38/28 ,  A61K38/385 ,  A61K45/06 ,  A61K47/545 ,  A61K48/0008 ,  A61K49/0002 ,  A61K49/0043 ,  A61K51/08 ,  A61K51/1265

Abstract: Lipidated micro- or macroparticles are prepared by covalently linking a glycoprotein, typically collagen, with at least one lipid. An amino group in the glycoprotein is joined with a primary amine in the lipid. These particles can be used to encapsulate active ingredients, such as drugs.

Abstract translation: 通过将糖蛋白（通常为胶原）与至少一种脂质共价连接来制备脂质化的微粒或大颗粒。 糖蛋白中的氨基与脂质中的伯胺结合。 这些颗粒可用于包封活性成分，如药物。

公开(公告)号：US20170273906A1

公开(公告)日：2017-09-28

申请号：US15505464

申请日：2015-06-18

Applicant: Ramot at Tel-Aviv University Ltd. ,  Tel Hashomer Medical Research Infrastructure and Services Ltd.

Inventor： Jonathan LEOR ,  Tamar BEN-MORDECHAI ,  Radka HOLBOVA-GELKOFF ,  Olga YARENCHYK ,  Rimona MARGALIT ,  Inbar ELRON-GROSS ,  Yifat GLUCKSAM-GALNOY

IPC: A61K9/127 ,  A61K31/555

CPC classification number: A61K9/1271 ,  A61K31/555

Abstract: Provided are liposomes including a lipid membrane enclosing an intraliposomal compartment. The liposomes may encapsulate an iron complex, including an iron moiety and a macromolecule, in the intraliposomal compartment. The liposomes may additionally have a targeting moiety associated with the liposomal membranes. The targeting moiety may be exposed at the liposome's outer surface. The liposomes exhibit an immunomodulatory effect or anti-cancer effect depending on the molar ratio between the lipids forming the lipid membrane and the iron complex. As such, the liposomes can be used to treat types of inflammation, particularly inflammations that are not associated or caused by infection or be used to treat cancer. Further provided are compositions including the disclosed liposomes, methods of using and kits including the liposomes.