公开(公告)号：US20240216510A1

公开(公告)日：2024-07-04

申请号：US18556172

申请日：2022-04-13

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD. ,  ICHILOV TECH LTD. ,  YEDA RESEARCH & DEVELOPMENT CO. LTD.

Inventor： Vered PADLER-KARAVANI ,  Ron AMON ,  Lihi NINIOMANY ,  Moran RAWET SLOBODKIN ,  Anat GLOBERSON LEVIN ,  Tova WAKS ,  Zelig ESHHAR

IPC: A61K39/00 ,  A61P35/00 ,  C07K14/705 ,  C07K14/725 ,  C07K16/30 ,  C12N5/0783

CPC classification number: A61K39/4631 ,  A61K39/4611 ,  A61K39/4613 ,  A61K39/464474 ,  A61P35/00 ,  C07K14/7051 ,  C07K14/70517 ,  C07K14/70521 ,  C07K14/70532 ,  C07K14/70575 ,  C07K14/70578 ,  C07K16/30 ,  C12N5/0636 ,  A61K2039/505 ,  C07K2317/622 ,  C07K2319/03 ,  C07K2319/30 ,  C12N2510/00

Abstract: The present invention discloses chimeric antigen receptors that specifically recognize and bind to Sialyl Tn carbohydrate antigen with high specificity and selectivity. The invention further provides lymphocytic cells, such as T cells, comprising said CARs, compositions comprising said cells or CARs as well as uses thereof.

公开(公告)号：US20240043561A1

公开(公告)日：2024-02-08

申请号：US18254255

申请日：2021-11-23

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Vered PADLER-KARAVANI ,  Ron AMON

IPC: C07K16/30 ,  A61K39/00

CPC classification number: C07K16/3076 ,  A61K39/4631 ,  A61K39/461 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/92 ,  C07K2317/622 ,  A61K2239/21 ,  A61K2239/13

Abstract: The present invention discloses humanized monoclonal antibodies that specifically bind to SLeA carbohydrate antigen with high specificity and selectivity, functional fragments of the humanized monoclonal antibodies such as scFv, and chimeric antigen receptors comprising the humanized monoclonal antibodies or the fragment thereof such as scFv. The invention further provides cells and compositions comprising the antibodies, fragments thereof or CARs as well as their use in diagnostics and treatment of cancer.

公开(公告)号：US20230174664A1

公开(公告)日：2023-06-08

申请号：US17779720

申请日：2020-11-25

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Vered PADLER-KARAVANI ,  Ron AMON ,  Ronit ROSENFELD

IPC: C07K16/28 ,  A61K47/68 ,  A61P35/00 ,  G01N33/574

CPC classification number: C07K16/2896 ,  A61K47/6849 ,  A61P35/00 ,  G01N33/57492 ,  C07K2317/92 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/622 ,  C07K2317/734 ,  G01N2400/02

Abstract: The present invention discloses novel monoclonal antibodies and functional fragments thereof that specifically bind to SLeA carbohydrate antigen with high specificity and selectivity. The invention further provides compositions comprising the antibodies or fragments thereof as well as uses of the antibodies, fragments and compositions.

公开(公告)号：US20240197882A1

公开(公告)日：2024-06-20

申请号：US18556161

申请日：2022-04-13

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Vered PADLER-KARAVANI ,  Ron AMON

IPC: A61K39/00 ,  C07K14/705 ,  C07K14/725 ,  C07K16/32 ,  C12N5/0783 ,  G01N33/574

CPC classification number: A61K39/464474 ,  A61K39/4611 ,  A61K39/4613 ,  A61K39/4631 ,  C07K14/7051 ,  C07K14/70517 ,  C07K14/70521 ,  C07K14/70532 ,  C07K14/70575 ,  C07K14/70578 ,  C07K16/32 ,  C12N5/0636 ,  G01N33/57492 ,  C07K2317/24 ,  C07K2319/03 ,  C07K2319/30 ,  G01N2440/38

Abstract: The present invention discloses humanized monoclonal antibodies that specifically bind to STn carbohydrate antigen with high specificity and selectivity, functional fragments of the humanized monoclonal antibodies such as scFv, conjugates and chimeric antigen receptors comprising the humanized monoclonal antibodies or the fragment thereof such as scFv. The invention further provides cells and compositions comprising the antibodies, fragments thereof or CARs as well as their use in diagnostics and treatment of cancer.

公开(公告)号：US20230058044A1

公开(公告)日：2023-02-23

申请号：US17779704

申请日：2020-11-25

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD. ,  ICHILOV TECH LTD. ,  YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Vered PADLER-KARAVANI ,  Yafit ATIYA-NASAGI ,  Ron AMON ,  Anat GLOBERSON LEVIN ,  Tova WAKS ,  Moran RAWET-SLOBODKIN ,  Lihi NINIO MANY ,  Zelig ESHHAR

IPC: A61K35/17 ,  C07K14/725 ,  C07K14/705 ,  C07K14/735 ,  C12N5/0783

Abstract: The present invention discloses chimeric antigen receptors that specifically recognize and bind to SLe A carbohydrate antigen with high specificity and selectivity. The invention further provides lymphocytic cells, such as T cells, comprising said CARs, compositions comprising said cells or CARs as well as uses thereof.