公开(公告)号：US20220135534A1

公开(公告)日：2022-05-05

申请号：US17577456

申请日：2022-01-18

申请人： REATA PHARMACEUTICALS, INC.

发明人： Xin JIANG ,  Christopher F. BENDER ,  Melean VISNICK ,  Martha R. HOTEMA ,  Zachary S. SHELDON ,  Chitase LEE ,  Bradley William CAPRATHE ,  Gary BOLTON ,  Brian KORNBERG

IPC分类号： C07D401/04 ,  C07D239/70 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D413/04 ,  C07D413/14 ,  C07D417/14

摘要： Disclosed herein are compounds of the formulas: as well as analogs thereof, wherein the variables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein may be used to inhibit RORγ and/or reduce the expression of IL-17. Also provided are methods of administering compounds and composition provided herein to a patient in need thereof, for example, for the treatment or prevention of diseases or disorders associated with inflammation or autoimmune disorders.

公开(公告)号：US20230250130A1

公开(公告)日：2023-08-10

申请号：US18149696

申请日：2023-01-04

申请人： REATA PHARMACEUTICALS, INC.

发明人： Melean VISNICK ,  Xin JIANG ,  Martha R. HOTEMA ,  Chitase LEE ,  Bradley William CAPRATHE ,  William H. ROARK ,  Gary L. BOLTON

IPC分类号： C07J63/00 ,  C07J71/00 ,  A61P29/00

CPC分类号： C07J63/008 ,  C07J71/0005 ,  A61P29/00

摘要： Disclosed herein are C4 modified oleanolic acid derivatives of the formula:




as well as analogs thereof, wherein the variables are defined herein. In addition, disclosed herein are pharmaceutical compositions of these derivatives or analogs, methods for their manufacture, and methods for their use, including for the prevention and treatment of diseases or disorders associated with overproduction of IL-17.

公开(公告)号：US20190153022A1

公开(公告)日：2019-05-23

申请号：US15760662

申请日：2016-09-23

申请人： REATA PHARMACEUTICALS, INC.

发明人： Melean VISNICK ,  Xin JIANG ,  Martha R. HOTEMA ,  Chitase LEE ,  Bradley William CAPRATHE ,  William H. ROARK ,  Gary L. BOLTON

IPC分类号： C07J63/00 ,  C07J71/00 ,  A61P29/00

摘要： Disclosed herein are C4 modified oleanolic acid derivatives of the formula: Formula (X) or Formula (XII), as well as analogs thereof, wherein the variables are defined herein. In addition, disclosed herein are pharmaceutical compositions of these derivatives or analogs, methods for their manufacture, and methods for their use, including for the prevention and treatment of diseases or disorders associated with overproduction of IL-17.

公开(公告)号：US20180127380A1

公开(公告)日：2018-05-10

申请号：US15548909

申请日：2016-02-12

申请人： REATA PHARMACEUTICALS, INC.

发明人： Xin JIANG ,  Bradley William CAPRATHE ,  Chitase LEE ,  Gary BOLTON ,  Christopher F. BENDER ,  Melean VISNICK

IPC分类号： C07D235/08 ,  A61P29/00 ,  C07D403/04 ,  C07D235/12 ,  C07D403/14 ,  C07D403/10 ,  C07D235/10 ,  C07D401/04

CPC分类号： C07D235/08 ,  A61P29/00 ,  C07D235/02 ,  C07D235/10 ,  C07D235/12 ,  C07D401/04 ,  C07D403/04 ,  C07D403/10 ,  C07D403/14

摘要： Disclosed herein are compounds of the formula: (I), wherein the variables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein may be used as antioxidant inflammation modulators. In some aspects, the present disclosure provides methods wherein the compounds and composition described herein are used for the treatment of diseases and disorders associated with inflammation and cancer.