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公开(公告)号：US09115212B2
公开(公告)日：2015-08-25
申请号：US14375414
申请日：2013-01-31
申请人： REGENTIS INTERNATIONAL , UNIVERSITE DE REIMS CHAMPAGNE ARDENNE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
IPC分类号： A61K38/16 , A61K38/00 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00 , C07K14/81 , A61Q19/08 , C07K14/78 , C07K5/083 , C07K5/11 , A61K8/64
CPC分类号： C07K14/8146 , A61K8/64 , A61K38/00 , A61Q19/08 , C07K5/0804 , C07K5/1019 , C07K14/78 , C07K2319/00 , C07K2319/50 , C07K2319/75
摘要： The bifunctional peptide is capable of activating collagen synthesis and inhibiting the production of matrix metallo-proteinases. The peptide has a sequence including three peptide parts A, B and C. The first peptide part A corresponds to a hexapeptide repeated at least three times, the part A being capable of bonding to a receptor elastin-binding protein in order to stimulate collagen synthesis. The second peptide part B corresponds to a tetrapeptide capable of acting as a competitive inhibitor of urokinase protease and of being cleaved by said protease. The third peptide part C corresponds to a tripeptide occupying at least one active site of the matrix metallo-proteinases in order to enable inhibition of the proteinases. The present invention further concerns a cosmetic and/or pharmaceutical composition incorporating the bifunctional peptide.
摘要翻译： 双功能肽能够激活胶原合成并抑制基质金属蛋白酶的产生。 肽具有包括三个肽部分A，B和C的序列。第一肽部分A对应于重复至少三次的六肽，部分A能够结合受体弹性蛋白结合蛋白以刺激胶原合成 。 第二肽部分B对应于能够作为尿激酶蛋白酶的竞争性抑制剂并被所述蛋白酶切割的四肽。 第三肽部分C对应于占据基质金属蛋白酶的至少一个活性位点的三肽，以便能够抑制蛋白酶。 本发明还涉及掺入双功能肽的化妆品和/或药物组合物。
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公开(公告)号：US20150031633A1
公开(公告)日：2015-01-29
申请号：US14375414
申请日：2013-01-31
申请人： REGENTIS INTERNATIONAL , UNIVERSITE DE REIMS CHAMPAGNE ARDENNE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
IPC分类号： C07K14/81
CPC分类号： C07K14/8146 , A61K8/64 , A61K38/00 , A61Q19/08 , C07K5/0804 , C07K5/1019 , C07K14/78 , C07K2319/00 , C07K2319/50 , C07K2319/75
摘要： The bifunctional peptide is capable of activating collagen synthesis and inhibiting the production of matrix metallo-proteinases. The peptide has a sequence including three peptide parts A, B and C. The first peptide part A corresponds to a hexapeptide repeated at least three times, the part A being capable of bonding to a receptor elastin-binding protein in order to stimulate collagen synthesis. The second peptide part B corresponds to a tetrapeptide capable of acting as a competitive inhibitor of urokinase protease and of being cleaved by said protease. The third peptide part C corresponds to a tripeptide occupying at least one active site of the matrix metallo-proteinases in order to enable inhibition of the proteinases. The present invention further concerns a cosmetic and/or pharmaceutical composition incorporating the bifunctional peptide.
摘要翻译： 双功能肽能够激活胶原合成并抑制基质金属蛋白酶的产生。 肽具有包括三个肽部分A，B和C的序列。第一肽部分A对应于重复至少三次的六肽，部分A能够结合受体弹性蛋白结合蛋白以刺激胶原合成 。 第二肽部分B对应于能够作为尿激酶蛋白酶的竞争性抑制剂并被所述蛋白酶切割的四肽。 第三肽部分C对应于占据基质金属蛋白酶的至少一个活性位点的三肽，以便能够抑制蛋白酶。 本发明还涉及掺入双功能肽的化妆品和/或药物组合物。
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