公开(公告)号：US3647797A

公开(公告)日：1972-03-07

申请号：US3647797D

申请日：1969-07-24

申请人： RICHARDSON MERRELL INC

发明人： CARR ALBERT A ,  MEYER DONALD R

IPC分类号： A61K31/395 ,  A61K31/445 ,  C07D209/54 ,  C07D209/96 ,  C07D211/88 ,  C07D221/10 ,  C07D221/20 ,  C07D29/20

CPC分类号： C07D221/20 ,  C07C255/00 ,  C07D209/96 ,  C07D211/88

摘要： COMPOUNDS HAVING THE GENERAL FORMULA

(-(CH2)Y-CO-N(-R3)-CO-)>C
(CH2)Y-)

WHEREIN R1 AND R2 REPRESENT HYDROGEN, HALOGEN, LOWER ALKYL, LOWER ALKOXY, OR NITRO, AND WHEREIN R1 AND R3 MAYU BE THE SAME OR DIFFERENT R3 MAY BY HUDROGEN OR LOWER ALKYL, AND X AND Y MAY BE ONE OR TWO. THEY HAVE BENN FOUND TO BE USEFUL SEDATIVE TYPE DEPRESSANTS OF THE CENTRAL NERVOUS SYSTEMS. MOST OF THE COMPOUNDS HAVING THE GENERAL FORMULA INDICATED ABOVE ARE NEW BUT OTHERS SUCH AS 2,3-DIHYDROSPRIO(NAPHTHALENE-1(4H),3'' - PIPERIDINE) - 2,4,6''-TRIONE WHICH HAS USEFUL SEDATIVE PROPERTIES HAVE BEEN REPORTED IN THE LITERATURE.

公开(公告)号：US3859312A

公开(公告)日：1975-01-07

申请号：US31714672

申请日：1972-12-21

申请人： RICHARDSON MERRELL INC

发明人： MEYER DONALD R ,  SILL ARTHUR D

IPC分类号： C07D211/14 ,  C07C67/00 ,  C07C213/00 ,  C07C219/14 ,  C07D221/12 ,  C07D295/088 ,  C07D311/80 ,  C07D7/26

CPC分类号： C07D295/088 ,  C07C2603/18 ,  C07C2603/26 ,  C07D221/12 ,  C07D311/80 ,  Y10S514/888 ,  Y10S514/937 ,  Y10S514/96 ,  Y10S514/962 ,  Y10S514/969

摘要： Novel bis basic esters of 9-substituted phenanthrene and related 9-oxa and 9-aza derivatives thereof, their preparation and use for the prevention and inhibition of viral infections are disclosed.

公开(公告)号：US3634490A

公开(公告)日：1972-01-11

申请号：US3634490D

申请日：1969-06-27

申请人： RICHARDSON MERRELL INC

发明人： CARR ALBERT A ,  MEYER DONALD R

IPC分类号： A61K31/27 ,  A61K31/325 ,  A61P3/04 ,  C07C67/00 ,  C07C239/00 ,  C07C271/06 ,  C07C271/18 ,  C07C125/06

CPC分类号： A61K31/27 ,  A61K31/325 ,  C07C271/06 ,  Y10S514/91

摘要： NOVEL COMPOUNDS SELECTED FROM THE FORMULA

(R2-OOC-N(-R1)-C(-R)(-CH3)-CO-)BENZENE

WHEREIN: R IS HYDROGEN OR METHYL; R1 IS HYDROGEN METHYL, ETHYL, OR ISOPROPYL; AMD R2 IS (LOWER) ALKYL OR BENZYL. THESE COMPOUNDS ARE APPETITE DEPRESSANTS.