公开(公告)号：US20150064281A1

公开(公告)日：2015-03-05

申请号：US14391559

申请日：2013-04-04

Applicant: ROHTO PHARMACEUTICAL CO., LTD.

Inventor： Kazuhiro Fukushima ,  Mariyo Kato ,  Yoshihiro Takai ,  Masashi Itoh

IPC: A61K31/155 ,  A61K33/30

CPC classification number: A61K31/155 ,  A61K31/785 ,  A61K33/22 ,  A61K33/30 ,  A61L12/142 ,  A61K2300/00

Abstract: The present invention provides an ophthalmic composition containing (A) a biguanide-based disinfectant and (B) zinc chloride. According to the present invention, an ophthalmic composition having remarkably increased disinfection effects against Acanthamoeba is provided.

Abstract translation: 本发明提供含有（A）双胍类消毒剂和（B）氯化锌的眼用组合物。 根据本发明，提供了对棘阿米巴具有显着提高的消毒效果的眼用组合物。

公开(公告)号：US09724312B2

公开(公告)日：2017-08-08

申请号：US14154688

申请日：2014-01-14

Applicant: ROHTO PHARMACEUTICAL CO., LTD.

Inventor： Takahiro Kurose ,  Takayuki Miyano ,  Mariyo Kato ,  Yoshihiro Takai

IPC: A61K31/121 ,  A61K47/02 ,  A61K45/06 ,  A61K9/00 ,  A61K47/26 ,  A61K47/44

CPC classification number: A61K31/121 ,  A61K9/0048 ,  A61K9/0053 ,  A61K45/06 ,  A61K47/02 ,  A61K47/26 ,  A61K47/44

Abstract: A prophylactic, ameliorating or therapeutic agent for a retinal disease, the agent comprising geranylgeranylacetone which (a) is a mixture of (5E,9E,13E)-geranylgeranylacetone and (5Z,9E,13E)-geranylgeranylacetone, the (5E,9E,13E)-geranylgeranylacetone content of the mixture being 80% by weight or more, (b) consists of (5E,9E,13E)-geranylgeranylacetone, or (c) consists of (5Z,9E,13E)-geranylgeranylacetone directly suppresses the death of a retinal cell, thereby fundamentally preventing, ameliorating or treating the retinal disease.