公开(公告)号：US09320802B2

公开(公告)日：2016-04-26

申请号：US14683579

申请日：2015-04-10

Applicant: ROHTO PHARMACEUTICAL CO., LTD.

Inventor： Chinatsu Furumiya ,  Takayuki Miyano ,  Atsuko Nakata ,  Eri Matsumoto

IPC: A61K47/10 ,  A61K47/44 ,  A61K9/08 ,  A61K9/00 ,  A61K47/02 ,  A61K47/26 ,  A61K47/24

CPC classification number: A61K47/44 ,  A61K9/0048 ,  A61K9/08 ,  A61K47/02 ,  A61K47/10 ,  A61K47/24 ,  A61K47/26

Abstract: This invention relates to an aqueous ophthalmic composition comprising (A) polyoxyethylene castor oil in which the average number of moles of added ethylene oxide is 2 to 12 and (B) terpenoid. According to the present invention, an aqueous ophthalmic composition having an improved foam disappearance speed can be obtained.

公开(公告)号：US09724312B2

公开(公告)日：2017-08-08

申请号：US14154688

申请日：2014-01-14

Applicant: ROHTO PHARMACEUTICAL CO., LTD.

Inventor： Takahiro Kurose ,  Takayuki Miyano ,  Mariyo Kato ,  Yoshihiro Takai

IPC: A61K31/121 ,  A61K47/02 ,  A61K45/06 ,  A61K9/00 ,  A61K47/26 ,  A61K47/44

CPC classification number: A61K31/121 ,  A61K9/0048 ,  A61K9/0053 ,  A61K45/06 ,  A61K47/02 ,  A61K47/26 ,  A61K47/44

Abstract: A prophylactic, ameliorating or therapeutic agent for a retinal disease, the agent comprising geranylgeranylacetone which (a) is a mixture of (5E,9E,13E)-geranylgeranylacetone and (5Z,9E,13E)-geranylgeranylacetone, the (5E,9E,13E)-geranylgeranylacetone content of the mixture being 80% by weight or more, (b) consists of (5E,9E,13E)-geranylgeranylacetone, or (c) consists of (5Z,9E,13E)-geranylgeranylacetone directly suppresses the death of a retinal cell, thereby fundamentally preventing, ameliorating or treating the retinal disease.