公开(公告)号：US09422246B2

公开(公告)日：2016-08-23

申请号：US14389139

申请日：2013-03-27

Applicant: ROHTO Pharmaceutical Co., Ltd.

Inventor： Takashi Shimizu

IPC: C07D233/96 ,  A61Q17/04 ,  A61K8/49 ,  A61Q19/00

CPC classification number: C07D233/96 ,  A61K8/49 ,  A61K8/494 ,  A61K8/4946 ,  A61Q17/04 ,  A61Q19/00

Abstract: A novel compound which has excellent ultraviolet-absorbing function (especially UVA absorbing function) and excellent hydrophilicity. A benzylidene azolidine derivative represented by structural formula (I) or a salt thereof. In structural formula (I), n represents an integer of 1-5; A1 represents O, S or N-A4; and each of A2, A3 and A4 independently represents a hydrogen atom, an alkyl group which may be substituted by a hydroxyl group and has 1-8 carbon atoms, or the like (provided that at least one of A2, A3 and A4 contains one or more hydroxyl groups). In this connection, when n is an integer of 2-5, the plurality of A3O— moieties may be the same as or different.

Abstract translation: 具有优异的紫外线吸收功能（特别是UVA吸收功能）和优异亲水性的新型化合物。 由结构式（I）表示的亚苄基偶氮化合物衍生物或其盐。 在结构式（I）中，n表示1-5的整数; A1代表O，S或N-A4; A2，A3和A4各自独立地表示氢原子，可以被羟基取代并具有1-8个碳原子的烷基等（条件是A2，A3和A4中的至少一个包含一个 或更多的羟基）。 在这一点上，当n为2-5的整数时，多个A3O-部分可以相同或不同。

公开(公告)号：US20150065728A1

公开(公告)日：2015-03-05

申请号：US14389139

申请日：2013-03-27

Applicant: ROHTO Pharmaceutical Co., Ltd.

Inventor： Takashi Shimizu

IPC: C07D233/96 ,  A61Q17/04 ,  A61K8/49

CPC classification number: C07D233/96 ,  A61K8/49 ,  A61K8/494 ,  A61K8/4946 ,  A61Q17/04 ,  A61Q19/00

Abstract: A novel compound which has excellent ultraviolet-absorbing function (especially UVA absorbing function) and excellent hydrophilicity. A benzylidene azolidine derivative represented by structural formula (I) or a salt thereof. In structural formula (I), n represents an integer of 1-5; A1 represents O, S or N-A4; and each of A2, A3 and A4 independently represents a hydrogen atom, an alkyl group which may be substituted by a hydroxyl group and has 1-8 carbon atoms, or the like (provided that at least one of A2, A3 and A4 contains one or more hydroxyl groups). In this connection, when n is an integer of 2-5, the plurality of A3O— moieties may be the same as or different.

Abstract translation: 具有优异的紫外线吸收功能（特别是UVA吸收功能）和优异亲水性的新型化合物。 由结构式（I）表示的亚苄基偶氮化合物衍生物或其盐。 在结构式（I）中，n表示1-5的整数; A1代表O，S或N-A4; A2，A3和A4各自独立地表示氢原子，可以被羟基取代并具有1-8个碳原子的烷基等（条件是A2，A3和A4中的至少一个包含一个 或更多的羟基）。 在这一点上，当n为2-5的整数时，多个A3O-部分可以相同或不同。