公开(公告)号：US20240025860A1

公开(公告)日：2024-01-25

申请号：US18339366

申请日：2023-06-22

申请人： Insilico Medicine IP Limited

发明人： Xiao DING ,  Jingjing PENG ,  Feng REN ,  Xiaoyu DING ,  Bogdan ZAGRIBELNYY ,  Yan A. IVANENKOV

IPC分类号： C07D233/96 ,  A61P31/14

CPC分类号： C07D233/96 ,  A61P31/14

摘要： Provided herein are compounds, pharmaceutical compositions, and methods for treating a SARS-CoV-2 infection.

公开(公告)号：US20230286956A1

公开(公告)日：2023-09-14

申请号：US18004952

申请日：2021-07-09

申请人： DUKSUNG WOMEN'S UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION ,  KNU-INDUSTRY COOPERATION FOUNDATION ,  INDUSTRY ACADEMIC COOPERATION FOUNDATION OF YEUNGNAM UNIVERSITY ,  EWHA UNIVERSITY - INDUSTRY COLLABORATION FOUNDATION

发明人： Sang Hyup LEE ,  Dong Young CHOI ,  Jungkwan LEE ,  Sung Hoon AHN ,  Sun CHOI ,  Hyun Sung CHO ,  Cho Rong KIM ,  Yoo Jin LIM ,  Ye Eun KIM ,  Yoonji LEE

IPC分类号： C07D403/10 ,  C07D233/96 ,  C07D401/06 ,  A61P25/28

CPC分类号： C07D403/10 ,  A61P25/28 ,  C07D233/96 ,  C07D401/06

摘要： The present invention relates to 1-alkyl-5-arylidene-2-selenoxoimidazolidine-4-ons and derivatives thereof, a method for producing the same, and a composition for prevention, improvement or treatment of neurodegenerative disease containing the same. Specifically, 1-alkyl-5-arylidene-2-selenoxoimidazolidine-4-ons and derivatives thereof, which are novel compounds of the present invention, can be used as an excellent composition for prevention, improvement or treatment of neurodegenerative disease.

公开(公告)号：US20230141569A1

公开(公告)日：2023-05-11

申请号：US17907018

申请日：2021-03-16

申请人： FLUORESCENCE DIAGNOSIS (SHANGHAI) BIOTECH COMPANY LTD.

发明人： Dasheng ZHANG

IPC分类号： C09B23/14 ,  C09K11/06 ,  C07D233/96 ,  C07D401/06 ,  C07D403/06 ,  C07D413/06 ,  G01N33/58 ,  C07D455/04

CPC分类号： C09B23/145 ,  C09K11/06 ,  C07D233/96 ,  C07D401/06 ,  C07D403/06 ,  C07D413/06 ,  G01N33/582 ,  C07D455/04 ,  C09K2211/1018 ,  C09K2211/1007

摘要： A fluorescent dye, a preparation method and uses thereof, wherein the fluorescent dye has the advantages of sensitivity and specificity to viscosity response, low background fluorescence and the like, and can also be used as a fluorescence activated and lightened-up probe for fluorescence labeling, quantification or detection of proteins, enzymes or nucleic acids.

公开(公告)号：US10011632B2

公开(公告)日：2018-07-03

申请号：US14917127

申请日：2012-08-21

申请人： Eric Wang ,  Hartmuth C. Kolb ,  Anna Katrin Szardenings ,  Changhui Liu ,  Joseph C. Walsh ,  Gang Chen ,  Anjana Sinha ,  Dhanalakshmi Kasi ,  Chul Yu ,  Umesh B. Gangadharmath ,  Wei Zhang ,  Tieming Zhao ,  Vani P. Mocharla

发明人： Eric Wang ,  Hartmuth C. Kolb ,  Anna Katrin Szardenings ,  Changhui Liu ,  Joseph C. Walsh ,  Gang Chen ,  Anjana Sinha ,  Dhanalakshmi Kasi ,  Chul Yu ,  Umesh B. Gangadharmath ,  Wei Zhang ,  Tieming Zhao ,  Vani P. Mocharla

IPC分类号： C07K5/02 ,  A61K51/04 ,  C07D249/06 ,  C07D249/04 ,  A61K51/08 ,  C07K5/062 ,  C07K5/072 ,  C07D403/12 ,  C07D213/81 ,  C07D213/82 ,  C07D233/78 ,  C07D233/96 ,  C07D401/12 ,  C07D403/06 ,  C07D405/12 ,  C07D239/60 ,  C07D251/30 ,  C07D263/34 ,  C07D207/16 ,  C07D277/56 ,  C07D209/48 ,  A61K38/00

CPC分类号： C07K5/0215 ,  A61K38/00 ,  A61K51/0402 ,  A61K51/0453 ,  A61K51/0497 ,  A61K51/088 ,  C07D207/16 ,  C07D209/48 ,  C07D213/81 ,  C07D213/82 ,  C07D233/78 ,  C07D233/96 ,  C07D239/60 ,  C07D249/04 ,  C07D249/06 ,  C07D251/30 ,  C07D263/34 ,  C07D277/56 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07K5/06026 ,  C07K5/06113

摘要： Compounds for targeting and agents for imaging, Prostate-specific membrane antigen (PSMA) are disclosed. Methods of synthesizing compounds and imaging agents, as well as methods for imaging PSMA are also disclosed. The imaging agents disclosed are suitable for PET and SPECT imaging.

公开(公告)号：US20180134667A1

公开(公告)日：2018-05-17

申请号：US15783678

申请日：2017-10-13

申请人： TES Pharma S.r.I.

发明人： Roberto Pellicciari

IPC分类号： C07D239/56 ,  C07D239/557 ,  C07D239/30 ,  C07D403/12 ,  C07D403/04 ,  C07D403/10

CPC分类号： C07D239/56 ,  C07D233/30 ,  C07D233/32 ,  C07D233/40 ,  C07D233/54 ,  C07D233/70 ,  C07D233/96 ,  C07D239/30 ,  C07D239/557 ,  C07D403/04 ,  C07D403/10 ,  C07D403/12

摘要： The present disclosure discloses compounds capable of modulating the activity of α-amino-β-carboxymuconic acid semialdehyde decarboxylase (ACMSD), which are useful for the prevention and/or the treatment of diseases and disorders associated with defects in NAD+ biosynthesis, e.g., metabolic disorders, neurodegenerative diseases, chronic inflammatory diseases, kidney diseases, and diseases associated with ageing. The present application also discloses pharmaceutical compositions comprising said compounds and the use of such compounds as a medicament.

公开(公告)号：US20180072682A1

公开(公告)日：2018-03-15

申请号：US15557762

申请日：2016-03-18

申请人： VECTUS BIOSYSTEMS LIMITED

发明人： KAREN ANNETTE DUGGAN

IPC分类号： C07D233/78 ,  C07C215/54 ,  C07D207/26 ,  C07D207/38 ,  C07D233/96 ,  C07D261/14 ,  C07D263/38 ,  C07C239/20 ,  C07D263/44 ,  C07D209/48 ,  C07C59/54 ,  C07C39/12

CPC分类号： C07D233/78 ,  C07C39/12 ,  C07C39/15 ,  C07C47/575 ,  C07C59/52 ,  C07C59/54 ,  C07C215/48 ,  C07C215/54 ,  C07C239/20 ,  C07D207/26 ,  C07D207/267 ,  C07D207/36 ,  C07D207/38 ,  C07D207/408 ,  C07D207/448 ,  C07D209/48 ,  C07D233/96 ,  C07D261/14 ,  C07D263/38 ,  C07D263/44

摘要： The present invention relates to novel compounds and their use in the prophylactic and/or therapeutic treatment of fibrosis and fibrosis-related conditions.

公开(公告)号：US09896421B2

公开(公告)日：2018-02-20

申请号：US14973752

申请日：2015-12-18

申请人： Pusan National University Industry-University Cooperation Foundation

发明人： Hae Young Chung ,  Hyung Ryong Moon ,  Min Hi Park ,  Young Mi Ha ,  Yun Jung Park ,  Ji Young Park ,  Jin Ah Kim ,  Ji Yeon Lee ,  Kyung Jin Lee

IPC分类号： A61K8/49 ,  A61Q19/02 ,  A61Q19/08 ,  C07D207/18 ,  C07D277/42 ,  C07D263/42 ,  C07D277/34 ,  C07D207/448 ,  C07D233/96 ,  C07D239/62 ,  A61Q19/04

CPC分类号： C07D263/42 ,  A61K8/49 ,  A61K8/4913 ,  A61K8/4946 ,  A61K8/4953 ,  A61Q19/02 ,  A61Q19/04 ,  A61Q19/08 ,  C07D207/18 ,  C07D207/448 ,  C07D233/96 ,  C07D239/62 ,  C07D277/34

摘要： Provided are a novel compound having skin-whitening, anti-oxidizing and PPAR activities and a medical use thereof, and the compound has skin-whitening activities for the suppression of tyrosinase, and accordingly, is useful for use in skin-whitening pharmaceutical composition or cosmetic products; has anti-oxidant activities, and accordingly, is useful for the prevention and treatment of skin-aging; and has PPAR activities, and in particular, PPARα and PPARγ activities, and accordingly, is useful for use in pharmaceutical compositions or health foods which are effective for the prevention and treatment of obesity, metabolic disease, or cardiovascular disease.

公开(公告)号：US20160151369A1

公开(公告)日：2016-06-02

申请号：US14776675

申请日：2014-03-11

申请人： ACUCELA INC.

发明人： Vladimir A. Kuksa ,  Mark W. Orme ,  Feng Hong ,  Ryo Kubota

IPC分类号： A61K31/505 ,  A61K31/4409 ,  A61K31/4406 ,  A61K31/4465 ,  A61K31/445 ,  A61K31/44 ,  A61K31/343 ,  A61K31/341 ,  A61K31/351 ,  A61K31/382

CPC分类号： C07D335/02 ,  A61K31/341 ,  A61K31/343 ,  A61K31/351 ,  A61K31/382 ,  A61K31/44 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/445 ,  A61K31/4465 ,  A61K31/505 ,  C07D207/08 ,  C07D207/09 ,  C07D207/26 ,  C07D209/08 ,  C07D209/14 ,  C07D211/22 ,  C07D211/26 ,  C07D211/60 ,  C07D211/76 ,  C07D211/96 ,  C07D213/30 ,  C07D213/38 ,  C07D233/64 ,  C07D233/96 ,  C07D239/26 ,  C07D279/02 ,  C07D307/12 ,  C07D307/14 ,  C07D307/80 ,  C07D307/81 ,  C07D309/04 ,  C07D309/06 ,  C07D311/04 ,  C07D311/58 ,  C07D333/12 ,  C07D333/16 ,  C07D333/20

摘要： The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are substituted 3-phenylpropylamine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.

摘要翻译： 本发明一般涉及用于治疗神经变性疾病和病症，特别是眼科疾病和病症的组合物和方法。 本文提供了取代的3-苯基丙胺衍生物化合物和包含所述化合物的药物组合物。 主题组合物可用于治疗和预防眼科疾病和病症，包括年龄相关性黄斑变性（AMD）和斯塔尔加氏病。

公开(公告)号：US20160102065A1

公开(公告)日：2016-04-14

申请号：US14973752

申请日：2015-12-18

申请人： Pusan National University Industry-University Cooperation Foundation

发明人： Hae Young CHUNG ,  Hyung Ryong MOON ,  Min Hi PARK ,  Young Mi HA ,  Yun Jung PARK ,  Ji Young PARK ,  Jin Ah KIM ,  Ji Yeon LEE ,  Kyung Jin LEE

IPC分类号： C07D263/42 ,  A61K8/49 ,  C07D207/448 ,  A61Q19/08 ,  C07D239/62 ,  C07D233/96 ,  C07D277/34 ,  A61Q19/02

CPC分类号： C07D263/42 ,  A61K8/49 ,  A61K8/4913 ,  A61K8/4946 ,  A61K8/4953 ,  A61Q19/02 ,  A61Q19/04 ,  A61Q19/08 ,  C07D207/18 ,  C07D207/448 ,  C07D233/96 ,  C07D239/62 ,  C07D277/34

摘要： Provided are a novel compound having skin-whitening, anti-oxidizing and PPAR activities and a medical use thereof, and the compound has skin-whitening activities for the suppression of tyrosinase, and accordingly, is useful for use in skin-whitening pharmaceutical composition or cosmetic products; has anti-oxidant activities, and accordingly, is useful for the prevention and treatment of skin-aging; and has PPAR activities, and in particular, PPARα and PPARγ activities, and accordingly, is useful for use in pharmaceutical compositions or health foods which are effective for the prevention and treatment of obesity, metabolic disease, or cardiovascular disease.

公开(公告)号：US09252446B2

公开(公告)日：2016-02-02

申请号：US14477381

申请日：2014-09-04

申请人： PEUGEOT CITROEN AUTOMOBILES S.A. ,  CNRS (CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE)

发明人： Xavier Glipa ,  Bruno Ameduri ,  Louis Delon ,  Deborah Jones ,  Jacques Roziere ,  Guillaume Frutsaert

IPC分类号： C07D235/10 ,  C08F26/06 ,  C25D17/00 ,  H01M8/10 ,  C07D233/64 ,  B01D71/62 ,  C07D233/96 ,  C08F214/18 ,  C08F216/14 ,  C08F226/06 ,  C08J5/22 ,  C25B13/08

CPC分类号： H01M8/103 ,  B01D71/62 ,  C07D233/64 ,  C07D233/96 ,  C07D235/10 ,  C08F26/06 ,  C08F214/186 ,  C08F216/1458 ,  C08F226/06 ,  C08J5/225 ,  C08J2327/12 ,  C08J2329/02 ,  C25B13/08 ,  C25D17/002 ,  H01M8/1027 ,  H01M8/1039 ,  H01M8/1072 ,  H01M2008/1095 ,  H01M2250/20 ,  H01M2300/0082 ,  Y02E60/521 ,  Y02P70/56 ,  Y02T90/32

摘要： The invention relates to a monomer (6, 14) carrying an imidazole-type heterocycle (3). According to the invention, the chemical structure of said monomer (6, 14) comprises at least one unit of formula (I) wherein R1 comprises an alkenyl grouping and R2 comprises a grouping for protecting one of the nitrogen atoms of the heterocycle. The invention also relates to a monomer carrying a benzimidazole-type heterocycle, and to protected polymers obtained from said monomers, deprotected polymers produced by the protected polymers, a proton exchange membrane based on deprotected polymers, and a fuel cell provided with said membrane. Furthermore, the invention relates to methods for producing the above-mentioned monomers and polymers.

摘要翻译： 本发明涉及携带咪唑型杂环（3）的单体（6,14）。 根据本发明，所述单体（6,14）的化学结构包含至少一个式（I）单元，其中R 1包含烯基，R 2包含用于保护杂环氮原子之一的基团。 本发明还涉及携带苯并咪唑型杂环的单体和由所述单体获得的保护的聚合物，由保护的聚合物制备的脱保护的聚合物，基于去保护的聚合物的质子交换膜，以及设置有所述膜的燃料电池。 此外，本发明涉及制备上述单体和聚合物的方法。