公开(公告)号：US3682964A

公开(公告)日：1972-08-08

申请号：US3682964D

申请日：1970-08-31

Applicant: ROUSSEL UCLAF

Inventor： ROUSSEAU GENEVIEVE ,  ALLAIS ANDRES ,  POITTEVIN ANDRE

IPC: C07C49/675 ,  C07C49/697 ,  C07C57/46 ,  C07C57/50 ,  C07C57/62 ,  C07C59/54 ,  C07C59/86 ,  C07C59/88 ,  C07D311/96 ,  A61K27/00 ,  C07D7/04 ,  C07D65/04

CPC classification number: C07D311/96 ,  C07C49/675 ,  C07C49/697 ,  C07C57/46 ,  C07C57/50 ,  C07C57/62 ,  C07C59/54 ,  C07C59/86 ,  C07C59/88

Abstract: Novel spiro benzocyclane acetic acid compounds of the formula

WHEREIN R is selected from the group consisting of hydrogen and linear and branched alkyl of one to four carbon atoms, R1 is selected from the group consisting of hydrogen, chlorine, trifluoromethyl and lower alkoxy, Y is selected from the group consisting of methylene, oxygen and sulfur, n is 2, 3 or 4 and R2 is selected from the group consisting of hydrogen, substituted or unsubstituted alkyl of one to six carbon atoms and cation of nontoxic, pharmaceutically acceptable mineral and organic bases, processes for their preparation and novel intermediates. The compounds of formula I have analgesic and anti-inflammatory properties.

Abstract translation: 式WHEREIN R的新型螺环苯并环丙烷乙酸化合物选自氢和1-4个碳原子的直链和支链烷基，R 1选自氢，氯，三氟甲基和低级烷氧基，Y是 选自亚甲基，氧和硫，n为2,3或4，R2选自氢，取代或未取代的1至6个碳原子的烷基和无毒，药学上可接受的矿物质的阳离子 和有机碱，其制备方法和新型中间体。 式I化合物具有止痛和抗炎特性。