公开(公告)号：US3781311A

公开(公告)日：1973-12-25

申请号：US3781311D

申请日：1971-12-29

Applicant: ROUSSEL UCLAF

Inventor： WARNANT J ,  JOLLY J

IPC: C07D317/72 ,  C07J1/00 ,  C07J75/00 ,  C07C169/20

CPC classification number: C07D317/72 ,  C07C2603/16 ,  C07J1/00 ,  C07J75/00

Abstract: A NOVEL PROCESS FOR THE PREPARATION OF TRIENIC STEROIDS OF THE FORMULA

3-(O=),17-HO,17-X,13-R-ESTRA-4,9,11-TRIENE

WHEREIN R IS ALKYL OF 1 TO 4 CARBON ATOMS AND X IS SELECTED FROM THE GROUP CONSISTING OF ALIPHATIC OF 1 TO 6 CARBON ATOMS OPTIONALLY SUBSTITUTED AND CYCLOALKYL OF 3 TO 6 CARBON ATOMS AND TO NOVEL INTERMEDIATES FOR THE SAID PROCESS.

公开(公告)号：US3761591A

公开(公告)日：1973-09-25

申请号：US3761591D

申请日：1972-02-29

Applicant: ROUSSEL UCLAF

Inventor： WARNANT J ,  FARCILLI A

IPC: A61K17/00

Abstract: 17 Alpha ,21-DIMETHYL-19-NOR- Delta 4,9-PREGNADIENE-3,20-DIONE OF THE FORMULA

HAVING ANTIGONADO-HYPOPHYSIAL, PROGESTOMIMETIC AND PROGESTATIVE ACTIVITY AND ITS PREPARATION.

Abstract translation: 17α，21-二甲基-19-异 - 四氢呋喃-4,9-孕酮-3,20-二酮，具有抗血管生成素，预防和预防活性及其制备方法。

公开(公告)号：US3770724A

公开(公告)日：1973-11-06

申请号：US3770724D

申请日：1971-03-22

Applicant: ROUSSEL UCLAF

Inventor： TOROMANOFF E ,  WARNANT J ,  FARCILLI A

IPC: C07D401/02 ,  C07D461/00 ,  C07D471/14 ,  C07D471/22 ,  C07D99/02

CPC classification number: C07D471/14 ,  C07D461/00

Abstract: PROCESS FOR PREPARING PENTACYCLIC ALKLOIDS OF GENERAL FORMULA:

12-(CH3-OOC-),12-HO,13A-(CH3-CH2-)-1,2,5,6,12,13-3H-
INDOLO(3,2,1-DE)PYRIDO(3,2,1-IJ)(1,5)NAPHTHYRIDINE

公开(公告)号：US3843686A

公开(公告)日：1974-10-22

申请号：US26736472

申请日：1972-06-29

Applicant: ROUSSEL UCLAF

Inventor： WARNANT J ,  JOLLY J ,  JOLY R

IPC: A41B1/00 ,  A41B3/00 ,  C07J1/00 ,  C07J7/00 ,  C07J41/00 ,  C07J73/00 ,  C07J75/00 ,  C07D13/00

CPC classification number: C07J73/00 ,  C07J1/00 ,  C07J7/00 ,  C07J41/00 ,  C07J75/00

Abstract: WHEREIN R represents a member selected from the group consisting of hydrogen and the acyl of an organic carboxylic acid having from one to 18 carbon atoms, R'' represents an alkyl having from one to four carbon atoms, Riv represents a member selected from the group consisting of lower alkyl, lower alkenyl or lower alkynyl, and B represents a member selected from the group consisting of two hydrogens in the 9 Alpha and 10 Beta position and a double bond which comprises the steps of reacting a 3ketal-4,5-seco-gonane-5-one with a ketalizing agent, oxidizing the resultant 3,5-diketal-4,5-seco-gonane-17 Beta -ol, reacting the resultant 3,5-diketal-4,5-seco-gonane-17-one with an organometallic compound, hydrolyzing the resultant 3,5-diketal17 Alpha -Riv-4,5-seco-gonane-17 Beta -ol, cyclizing the resultant 17 Alpha -Riv-4,5-seco-gonane-17 Beta -ol-3,5-dione and recovering said Delta 4-gonenic steroid. The novel intermediates are also part of the invention. The Delta 4-gonenic steroids are known compounds having steroidal properties.

A process for the production of a Delta 4-gonenic steroid having the formula