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公开(公告)号：US20110287019A1
公开(公告)日：2011-11-24
申请号：US13158506
申请日：2011-06-13
申请人： ROXANNE DUAN , MICHAEL KINCH , MICHAEL GOLDBLATT
发明人： ROXANNE DUAN , MICHAEL KINCH , MICHAEL GOLDBLATT
IPC分类号： A61K39/395 , C07K16/18 , A61P31/22 , A61P31/14 , A61P31/18 , A61P31/20 , A61K39/00 , C07K2/00
CPC分类号： C07K16/18
摘要： The invention provides for inhibition of viral disease by the provision to a mammalian host of antibodies directed against an escort protein like Tsg101. These proteins appear on the surface of a cell, and thus can be bound by circulating antibodies thereto. By binding escort proteins on the cell surface, budding of viral particles is inhibited. The virus infects the initial cells, but cannot escape that cell to infect the body en masse.
摘要翻译： 本发明通过向哺乳动物宿主提供针对诸如Tsg101之类的护送蛋白的抗体来提供对病毒性疾病的抑制。 这些蛋白质出现在细胞的表面上，因此可以通过循环其抗体而结合。 通过在细胞表面结合护送蛋白，病毒颗粒的出芽被抑制。 病毒感染初始细胞，但不能逃避该细胞大量感染身体。
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公开(公告)号：US20100286248A1
公开(公告)日：2010-11-11
申请号：US12566951
申请日：2009-09-25
申请人： WU-BO LI , MICHAEL KINCH , MICHAEL GOLDBLATT
发明人： WU-BO LI , MICHAEL KINCH , MICHAEL GOLDBLATT
CPC分类号： G01N33/6896 , C07K14/4711 , G01N2800/2821
摘要： A human gene, fg01, on chromosome 8, is identified. This gene, and its expression product, human fg01, shares a homology under 70% with the corresponding murine gene, which has been linked to presentation of the Alzheimer's phenotype of Aβ plaques and hyperphosphorylated tau tangles. Upregulation appears to suppress the Alzheimer's phenotype, which may be effective in preventing the onset of symptoms or progression of symptoms associated with AD. Screening methods are also set forth.
摘要翻译： 鉴定出染色体8上的人类基因fg01。 该基因及其表达产物人fg01与相应的鼠基因具有70％以下的同源性，其与A＆bgr的阿尔茨海默氏症表现呈现相关; 斑块和超磷酸化tau缠结。 上调似乎可以抑制阿尔茨海默病的表型，这可能有效预防与AD有关的症状或进展症状。 还阐述了筛选方法。
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