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公开(公告)号：US08501153B2
公开(公告)日：2013-08-06
申请号：US12880218
申请日：2010-09-13
申请人： Radha Achanath , Srinath Balaji , Afsal M. Kadavilpparampu Mohamed , Umamaheshwar Mokkapati , Steven Fairway , Dimitrios Mantzilas , Dennis O'Shea , William John Trigg , Harry John Wadsworth , Joanna Marie Passmore , Bo Shan
发明人： Radha Achanath , Srinath Balaji , Afsal M. Kadavilpparampu Mohamed , Umamaheshwar Mokkapati , Steven Fairway , Dimitrios Mantzilas , Dennis O'Shea , William John Trigg , Harry John Wadsworth , Joanna Marie Passmore , Bo Shan
CPC分类号： C07D209/94 , A61K51/0446 , A61K51/0455 , A61K51/0468 , C07B59/002 , C07B2200/05 , C07D209/88 , C07D295/192 , C07D401/06 , C07D495/04
摘要： The present invention provides a PET tracer that has improved properties for imaging the peripheral benzodiazepine receptor (PBR) as compared with known such PET tracers. The present invention also provides a precursor compound useful in the preparation of the PET tracer of the invention and methods for the preparation of said precursor compound and said PET tracer. Also provided by the present invention is a radiopharmaceutical composition comprising the PET tracer of the invention. Methods for using the PET tracer and the radiopharmaceutical composition are also provided.
摘要翻译： 本发明提供了与已知的这种PET示踪剂相比具有改进的外周苯并二氮杂受体（PBR）成像的特性的PET示踪剂。 本发明还提供了可用于制备本发明的PET示踪剂的前体化合物和用于制备所述前体化合物和所述PET示踪剂的方法。 本发明还提供了包含本发明的PET示踪剂的放射性药物组合物。 还提供了使用PET示踪剂和放射性药物组合物的方法。
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公开(公告)号：US20130121926A1
公开(公告)日：2013-05-16
申请号：US13805457
申请日：2011-06-29
IPC分类号： C09B23/08
CPC分类号： C09B23/086 , C07D209/14 , C09B67/0034 , G01N33/583
摘要： The present invention relates to sulfonated optical dye compositions, especially dyes suitable for biological applications in vitro, and for in vivo imaging. Improved dye compositions and intermediates are provided, which enable the suppression of undesirable newly-identified impurities. Also provided is the use of the improved dye compositions in the preparation of conjugates with biological targeting molecules.
摘要翻译： 本发明涉及磺化光学染料组合物，特别是适用于体外生物应用的染料和用于体内成像的染料。 提供改进的染料组合物和中间体，其能够抑制不期望的新鉴定的杂质。 还提供了改进的染料组合物在与生物靶向分子的共轭物的制备中的用途。
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3.发明授权公开(公告)号：US08338638B2
公开(公告)日：2012-12-25
申请号：US12438943
申请日：2007-08-24
IPC分类号： C07C237/28 , C07C65/01 , C07C229/54 , A01N37/18
CPC分类号： A61K31/192 , C07C65/05 , C07C69/157 , C07C69/63 , C07C205/60 , C07C235/64 , C07D499/74
摘要： Derivatives of anacardic acid having antimicrobial properties and method for preparing said derivatives. The antimicrobial properties include bacteriostatic and bacteriocidal activity.
摘要翻译： 具有抗微生物性质的漆树酸的衍生物和制备所述衍生物的方法。 抗菌性能包括抑菌和杀菌活性。
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4.发明申请公开(公告)号：US20100016630A1
公开(公告)日：2010-01-21
申请号：US12438943
申请日：2007-08-24
IPC分类号： C07C59/64 , C07C205/04 , C07C201/16 , C07C51/42
CPC分类号： A61K31/192 , C07C65/05 , C07C69/157 , C07C69/63 , C07C205/60 , C07C235/64 , C07D499/74
摘要： Derivatives of anacardic acid having antimicrobial properties and method for preparing said derivatives. The antimicrobial properties include bacteriostatic and bacteriocidal activity.
摘要翻译： 具有抗微生物性质的漆树酸的衍生物和制备所述衍生物的方法。 抗菌性能包括抑菌和杀菌活性。
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