公开(公告)号：US4886791A

公开(公告)日：1989-12-12

申请号：US219058

申请日：1988-07-13

申请人： Raffaello Giorgi ,  Marisa Conti ,  Giorgio Pifferi

发明人： Raffaello Giorgi ,  Marisa Conti ,  Giorgio Pifferi

IPC分类号： A61K31/665 ,  A61P1/16 ,  A61P9/00 ,  A61P9/10 ,  A61P25/28 ,  A61P39/02 ,  C07F9/09 ,  C07F9/655 ,  C07F9/6558

CPC分类号： C07F9/65586

摘要： Novel water-soluble derivatives of silybin of enhanced activity are provided as well as methods of preparing the derivatives and pharmaceutical compositions containing them. The novel derivatives according to the invention have the following general formula (I); ##STR1## where: R=H or PO(OH).sub.2 and R'=PO(OH).sub.2 The compounds of the invention are useful inter alia in therapy of liver disorders and other applications where an anti-radical effect is required. They have the advantages of high hydrophilicity and are soluble at approximately pH 4, compared to prior art compounds which are water-soluble only at higher pH and enhanced stability.

公开(公告)号：US4879311A

公开(公告)日：1989-11-07

申请号：US222552

申请日：1988-07-21

申请人： Raffaello Giorgi ,  Marisa Conti ,  Giorgio Pifferi

发明人： Raffaello Giorgi ,  Marisa Conti ,  Giorgio Pifferi

IPC分类号： A61K31/245 ,  A61K31/24 ,  A61P25/04 ,  A61P29/00 ,  C07C67/00 ,  C07C227/00 ,  C07C227/18 ,  C07C229/58

CPC分类号： A61K31/24

摘要： Benzoyoxyacetic acid derivatives of formula (I) ##STR1## wherein M denotes hydrogen or one equivalent of a pharmaceutically acceptable inorganic or organic cation are useful as analgesics and anti-inflammatory agents. A novel process for their preparation is also disclosed along with novel intermediates.

公开(公告)号：US5196449A

公开(公告)日：1993-03-23

申请号：US557558

申请日：1990-06-24

申请人： Maria J. Magistretti ,  Marisa Conti ,  Giorgio Pifferi

发明人： Maria J. Magistretti ,  Marisa Conti ,  Giorgio Pifferi

IPC分类号： C07D311/62 ,  A61K31/00 ,  A61K31/35 ,  A61K31/352 ,  A61K31/353 ,  A61P9/00 ,  A61P9/14 ,  A61P27/00 ,  A61P27/02

CPC分类号： A61K31/35 ,  Y10S514/912

摘要： The anthocyanidins pelargonidin and delphidin, have been found to possess novel and unexpected activity in the ophthalmic field, specifically that they are active in reducing the permeability of ciliary body vessels. According to one aspect of the present invention there is provided a method of reducing the hyperpermeability of the ciliary body ocular vessels in a subject which comprises administering to the subject an effective dose of pelargonidin or delphidin. The invention further provides the use of pelargonidin or delphidin in the manufacture of pharmaceutical compositions for carrying out the method of treatment referred to above.

公开(公告)号：US4709076A

公开(公告)日：1987-11-24

申请号：US743073

申请日：1985-06-10

申请人： Ezio Bombardelli ,  Bruno Gabetta ,  Marisa Conti

发明人： Ezio Bombardelli ,  Bruno Gabetta ,  Marisa Conti

IPC分类号： A61K31/215 ,  A61P13/02 ,  A61P15/00 ,  C07C69/734 ,  C07C69/76

CPC分类号： A61K31/215 ,  C07C69/734

摘要： Unsaturated esters of formula I ##STR1## in which R.sub.1, R.sub.2 and R.sub.3, which are the same or different to one another, represent hydrogen, hydroxyl, methoxyl or acetoxyl; n is between 13 and 25; are useful in the treatment of prostatic hyperplasia or hypertrophy.

摘要翻译： 式I的不饱和酯，其中R1，R2和R3彼此相同或不同，表示氢，羟基，甲氧基或乙酰氧基; n在13和25之间; 可用于治疗前列腺增生或肥大。