Buffered nicotine containing products
    3.
    发明申请
    Buffered nicotine containing products 审中-公开
    缓冲尼古丁含有产品

    公开(公告)号:US20080286340A1

    公开(公告)日:2008-11-20

    申请号:US11803747

    申请日:2007-05-16

    摘要: A pharmaceutical oral formulation for delivering nicotine in any form to a subject by transmucosal uptake in the oral cavity comprising nicotine in any form, wherein said oral formulation is buffered with at least one amino acid, preferably at least one endogenous amino acid. Also contemplated is a method for the oral delivery of nicotine in any form, a method for the reduction of the urge to smoke or use tobacco as well as methods for manufacturing the oral formulation, the use of said oral formulation for obtaining transmucosal uptake of nicotine in the oral cavity of a subject, and use of nicotine for the production of an oral formulation as per above for the treatment of a disease selected from the group consisting of tobacco or nicotine dependence, Alzheimer's disease, Crohn's disease, Parkinson's disease, Tourette's syndrome, ulcerous colitis and post-smoking-cessation weight control.

    摘要翻译: 一种药物口服制剂,其用于通过口腔内经粘膜摄取将任何形式的尼古丁以任何形式递送至任何形式的尼古丁,其中所述口服制剂用至少一种氨基酸,优选至少一种内源性氨基酸缓冲。 还考虑了以任何形式口服输送尼古丁的方法,减少吸烟或使用烟草的欲望的方法以及制备口服制剂的方法,所述口服制剂用于获得尼古丁的经粘膜摄取 在受试者的口腔中,以及使用尼古丁制备如上所述的口服制剂用于治疗选自烟草或尼古丁依赖性疾病,阿尔茨海默氏病,克罗恩病,帕金森氏病,图雷特综合征 ,溃疡性结肠炎和戒烟后重量控制。