-
公开(公告)号：US07361346B1
公开(公告)日：2008-04-22
申请号：US09152698
申请日：1998-09-02
申请人： Ragupathy Madiyalakan , Antoine A. Noujaim , Richard P. Baum , Birgit Schultes , Beatrice Leveugle , Fernando Kreutz
发明人： Ragupathy Madiyalakan , Antoine A. Noujaim , Richard P. Baum , Birgit Schultes , Beatrice Leveugle , Fernando Kreutz
IPC分类号： A61K39/00 , A61K39/385
CPC分类号： C07K16/4266 , A61K2039/505 , C07K2317/732 , C07K2317/734
摘要： The invention provides a method for stimulating the production of antibodies to a cryptic epitope on a soluble antigen by administering to a patient having such a cryptic epitope a binding agent that binds to the soluble antigen and forming a complex between the binding agent and the soluble antigen, wherein the cryptic epitope is exposed and the patient generates antibodies that bind to the cryptic epitope.
摘要翻译： 本发明提供了一种通过向具有这样的隐性表位的患者施用结合于可溶性抗原并在结合剂和可溶性抗原之间形成复合物的结合剂来刺激对可溶性抗原上的隐性表位产生抗体的方法 ，其中所述隐性表位被暴露，并且所述患者产生结合所述隐性表位的抗体。
-
2.发明授权Method and composition for reconforming multi-epitopic antigens to initiate an immune response 失效用于重构多表位抗原以引发免疫应答的方法和组合物公开(公告)号：US06241985B1
公开(公告)日：2001-06-05
申请号：US08913290
申请日：1998-03-20
IPC分类号： A61K39395
CPC分类号： A61K39/39558 , A61K39/00 , A61K2039/505 , C07K16/303 , C07K16/3069 , C07K16/4266 , C07K2317/55 , C07K2317/622 , C07K2317/732 , C07K2317/734 , C07K2317/76 , A61K38/177 , A61K2300/00
摘要： The invention concerns methods and compositions for intiating and/or enhancing an immune response by contacting a binding reagent with a soluble antigen, wherein the binding reagent-antigen pair generates an immune response to the antigen.
摘要翻译： 本发明涉及通过使结合试剂与可溶性抗原接触来引导和/或增强免疫应答的方法和组合物，其中结合试剂 - 抗原对产生对抗原的免疫应答。
-
3.发明授权Reagents and methods for inducing an immune response to prostate specific antigen 有权用于诱导对前列腺特异性抗原的免疫应答的试剂和方法公开(公告)号：US06881405B2
公开(公告)日：2005-04-19
申请号：US09332866
申请日：1999-06-15
IPC分类号： A61K39/395 , A61K39/00 , A61K39/385 , A61P13/08 , A61P15/00 , A61P35/00 , C07K16/40 , C07K16/42
CPC分类号： C07K16/4208 , A61K39/00 , A61K2039/505 , C07K16/40
摘要： The invention is an apparatus and method for the treatment of prostate cancer, and involves administering an antibody that specifically binds with prostate antigen.
摘要翻译： 本发明是用于治疗前列腺癌的装置和方法，并且涉及施用与前列腺抗原特异性结合的抗体。
-
公开(公告)号：US6086873A
公开(公告)日：2000-07-11
申请号：US877511
申请日：1997-06-17
IPC分类号： A61K39/00 , A61K39/395 , A61P35/00 , A61P37/04 , C07K16/30
CPC分类号： A61K39/39558 , C07K16/303 , C07K16/3069 , C07K16/4266 , A61K2039/505 , A61K39/00 , C07K2317/55 , C07K2317/622 , C07K2317/732 , C07K2317/734 , C07K2317/76
摘要： The present invention is methods and compositions including a photoactivated antibody that is capable of generating or increasing an immune response.
摘要翻译： 本发明是包括能够产生或增加免疫应答的光活化抗体的方法和组合物。
-
5.发明申请Method and composition for reconforming multi-epitopic antigens to intiate an immune response 审中-公开用于重建多表位抗原以诱导免疫应答的方法和组合物公开(公告)号：US20080131443A1
公开(公告)日：2008-06-05
申请号：US11981714
申请日：2007-10-31
IPC分类号： A61K39/395 , A61P35/00
CPC分类号： A61K39/39558 , A61K39/00 , A61K2039/505 , C07K16/303 , C07K16/3069 , C07K16/4266 , C07K2317/55 , C07K2317/622 , C07K2317/732 , C07K2317/734 , C07K2317/76 , A61K38/177 , A61K2300/00
摘要： The invention concerns methods and compositions for initiating and/or enhancing an immune response by contacting a binding reagent with a soluble antigen, wherein the binding reagent-antigen pair generates an immune response to the antigen.
摘要翻译： 本发明涉及通过使结合试剂与可溶性抗原接触来引发和/或增强免疫应答的方法和组合物，其中结合试剂 - 抗原对产生对抗原的免疫应答。
-
公开(公告)号：US20090202560A1
公开(公告)日：2009-08-13
申请号：US11981732
申请日：2007-10-31
IPC分类号： A61K39/395 , A61P35/00
CPC分类号： C07K16/3069 , A61K2039/505 , C07K16/4266 , C07K2317/732 , C07K2317/76 , G01N33/5091 , G01N33/6854
摘要： The invention concerns methods and compositions for intiating and/or enhancing an immune response by contacting a binding reagent with a soluble antigen, wherein the binding reagent-antigen pair generates an immune response to the antigen.
摘要翻译： 本发明涉及通过使结合试剂与可溶性抗原接触来引导和/或增强免疫应答的方法和组合物，其中结合试剂 - 抗原对产生对抗原的免疫应答。
-
公开(公告)号：US08038994B2
公开(公告)日：2011-10-18
申请号：US10831886
申请日：2004-04-26
IPC分类号： A61K39/395
CPC分类号： C07K16/3069 , A61K39/39558 , A61K2039/505 , A61K2300/00
摘要： Disclosed are methods for treating cancer comprising administering a xenotypic antibody and a chemotherapeutic drug to a patient suffering from cancer. Also disclosed is a method for inducing a host immune response in a patient against a multi-epitopic in vivo tumor antigen present in the host serum, which antigen does not elicit an effective host immune response, comprising administering to the patient a chemotherapeutic drug and a composition comprising a binding agent that specifically binds to a first epitope on the antigen and allowing the binding agent to form a binding agent/antigen pair, wherein an effective host immune response is elicited against a second epitope on the antigen.
摘要翻译： 公开了用于治疗癌症的方法，包括向患有癌症的患者施用异型抗体和化学治疗药物。 还公开了一种诱导患者中存在于宿主血清中的多表位体内肿瘤抗原的宿主免疫应答的方法，该抗原不引起有效的宿主免疫应答，其包括向患者施用化学治疗药物和 组合物，其包含特异性结合抗原上的第一表位并使结合剂形成结合剂/抗原对的结合剂，其中针对抗原上的第二表位引起有效的宿主免疫应答。
-
公开(公告)号：US20080311127A1
公开(公告)日：2008-12-18
申请号：US11981713
申请日：2007-10-31
IPC分类号： A61K39/395 , A61P35/00
CPC分类号： A61K39/39558 , A61K39/00 , A61K2039/505 , C07K16/303 , C07K16/3069 , C07K16/4266 , C07K2317/55 , C07K2317/622 , C07K2317/732 , C07K2317/734 , C07K2317/76 , A61K38/177 , A61K2300/00
摘要： Disclosed are methods for treating cancer comprising administering a xenotypic antibody and a chemotherapeutic drug to a patient suffering from cancer. Also disclosed is a method for inducing a host immune response in a patient against a multi-epitopic in vivo tumor antigen present in the host serum, which antigen does not elicit an effective host immune response, comprising administering to the patient a chemotherapeutic drug and a composition comprising a binding agent that specifically binds to a first epitope on the antigen and allowing the binding agent to form a binding agent/antigen pair, wherein an effective host immune response is elicited against a second epitope on the antigen.
摘要翻译： 公开了用于治疗癌症的方法，包括向患有癌症的患者施用异型抗体和化学治疗药物。 还公开了一种诱导患者中存在于宿主血清中的多表位体内肿瘤抗原的宿主免疫应答的方法，该抗原不引起有效的宿主免疫应答，包括向患者施用化学治疗药物和 组合物，其包含特异性结合抗原上的第一表位并使结合剂形成结合剂/抗原对的结合剂，其中针对抗原上的第二表位引起有效的宿主免疫应答。
-
公开(公告)号：US20090220493A1
公开(公告)日：2009-09-03
申请号：US11981715
申请日：2007-10-31
申请人： Beatrice Leveugle , Ragupathy Madiyalakan , Antoine A. Noujaim , Birgit C. Schultes , Bruce Darryl Hirsche
发明人： Beatrice Leveugle , Ragupathy Madiyalakan , Antoine A. Noujaim , Birgit C. Schultes , Bruce Darryl Hirsche
IPC分类号： A61K39/395 , A61P35/00 , C07K16/42
CPC分类号： C07K16/4208 , A61K39/00 , A61K2039/505 , C07K16/40
摘要： The invention is an apparatus and method for the treatment of prostate cancer, and involves administering an antibody that specifically binds with prostate antigen.
-
公开(公告)号：US07579445B2
公开(公告)日：2009-08-25
申请号：US10966789
申请日：2004-10-14
IPC分类号： C07K16/00
CPC分类号： C07K16/4208 , A61K39/00 , A61K2039/505 , C07K16/40
摘要： The invention is an apparatus and method for the treatment of prostate cancer, and involves administering an antibody that specifically binds with prostate antigen.
-
-
-
-
-
-
-
-
-
搜索结果
14 条记录 (耗时 0.026 秒)
