公开(公告)号：US4654595A

公开(公告)日：1987-03-31

申请号：US612657

申请日：1984-05-21

Applicant: Raimo Sepponen

Inventor： Raimo Sepponen

IPC: G01R33/54 ,  G01R33/20

CPC classification number: G01R33/482

Abstract: A nuclear magnetic resonance signal is collected from a target by using a special pulse sequence which is repeated and, between various repetitions, the relative temporal ratio of signal collection and excitation events is changed. The pulse sequence consists e.g. of the following actions: a target zone is first excited with a so-called 90.degree. pulse followed by coupling of magnetic field gradients in a manner that re-excitation of the target with a 180.degree. pulse serves to generate a so-called spin echo, which is stored and during which at least one magnetic field gradient is turned on. If the purpose is to image a three-dimensional target, e.g. the first excitation event can be effected by using so-called selective excitation and by using a gradient pulse orthogonal to the direction of a read gradient for phase encoding a nuclear system. Phase encoding can also be made in directions orthogonal to said read gradient and to each other to produce this way a complete three-dimensional local distribution of the chemical spectrum of a target.

Abstract translation: 通过使用重复的特殊脉冲序列从目标收集核磁共振信号，并且在各种重复之间，信号收集和激发事件的相对时间比率改变。 脉冲序列包括例如 以下动作：首先用所谓的90度脉冲激发目标区域，然后以180度脉冲重新激发目标的方式耦合磁场梯度，以产生所谓的自旋回波 ，其中存储至少一个磁场梯度。 如果目的是成像三维目标，例如。 可以通过使用所谓的选择性激励和使用与用于相位编码核系统的读梯度的方向正交的梯度脉冲来实现第一激励事件。 也可以在与所述读取梯度正交的方向上进行相位编码，并且相互编码以产生目标的化学谱的完整的三维局部分布。

公开(公告)号：US4587493A

公开(公告)日：1986-05-06

申请号：US510350

申请日：1983-07-01

Applicant: Raimo Sepponen

Inventor： Raimo Sepponen

IPC: A61B10/00 ,  A61B5/055 ,  G01R33/34 ,  H01F5/00 ,  G01N27/00

CPC classification number: G01R33/34007 ,  G01R33/34069 ,  G01R33/34084

Abstract: An adjustable signal coil, for example a solenoid, saddle or Helmholz type of signal coil which is used in a nuclear spin or NMR examination assembly, includes a pair of adjustable conductor guide and profile supports which hold one or more turns of a conductor forming the signal coil. The coil volume is changed by adjusting the supports to correspond to different sizes of targets to be positioned and examined inside the coil. In a disclosed embodiment, the coil volume is cylindrical and has its diameter changed by adjusting the spacing between the pair of supports, and the coil turn length and size, are adjusted by sliding guides within guideways of the supports.

Abstract translation: 用于核自旋或核磁共振检查组件中的可调信号线圈，例如螺线管，鞍形或亥姆霍兹型信号线圈，包括一对可调导体引导件和型材支架，其保持一匝或多匝导体，形成 信号线圈。 通过调节支撑件来改变线圈体积，以对应于在线圈内定位和检查的不同尺寸的目标。 在所公开的实施例中，线圈体积是圆柱形的，并且通过调节一对支撑件之间的间距而改变其直径，并且通过在支撑件的导轨内的滑动导轨来调节线圈转动长度和尺寸。

公开(公告)号：US5154603A

公开(公告)日：1992-10-13

申请号：US596482

申请日：1990-10-12

Applicant: Raimo Sepponen

Inventor： Raimo Sepponen

IPC: G01R33/54 ,  G01R33/62

CPC classification number: G01R33/482 ,  G01R33/62

Abstract: The invention relates to a method and apparatus for the examination of a moving component by the application of NMR methods and dynamic nuclear polarization (DNP). The saturation of electron spins required by DNP is adapted to occur within such area of an object in which the polarizing magnetic field has a different strength from the area of object which is subjected to NMR operations.

Abstract translation: 本发明涉及通过应用NMR方法和动态核极化（DNP）来检测移动部件的方法和装置。 DNP要求的电子自旋的饱和度适用于偏振磁场与经受NMR操作的物体的面积不同的强度的物体的这样的区域内。

公开(公告)号：US4906931A

公开(公告)日：1990-03-06

申请号：US255233

申请日：1988-10-11

Applicant: Raimo Sepponen

Inventor： Raimo Sepponen

IPC: A61B10/00 ,  A61B5/055 ,  G01R33/34 ,  G01R33/48

CPC classification number: G01R33/445 ,  G01R33/34053 ,  G01R33/34069 ,  G01R33/5602

Abstract: The invention relates to an apparatus for the examination of an object by the application of methods, such as magnetic imaging, based on nuclear magnetic resonance. The apparatus includes means for creating a first magnetic field over an object to be examined as well as means for creating and registering a nuclear magnetic resonance signal. The apparatus further includes means for creating a second magnetic field in a manner that the formation of nuclear magnetization occurring between successive excitation and signal pick-up events is at least partially effected while the second magnetic field is switched on.

Abstract translation: 本发明涉及一种用于通过应用基于核磁共振的诸如磁性成像的方法来检查物体的装置。 该装置包括用于在待检查对象上产生第一磁场的装置以及用于创建和登记核磁共振信号的装置。 该装置还包括用于产生第二磁场的装置，使得在第二磁场接通时至少部分地实现在连续的激励和拾取事件之间发生的核磁化的形成。

公开(公告)号：US4654594A

公开(公告)日：1987-03-31

申请号：US561339

申请日：1983-12-14

Applicant: Raimo Sepponen

Inventor： Raimo Sepponen

IPC: G01R33/54 ,  G01R33/20

CPC classification number: G01R33/4835

Abstract: The invention relates to a method of recovering nuclear spin or NMR information about a target, such as a human body placed in at least substantially homogenous magnetic field, a desired part of the target being excited by means of a radiofrequency magnetic field which preferably deviates nuclear magnetization through 90.degree., a so-called spin echo is generated by utilizing a second excitation of the target volume which preferably deviates nuclear magnetization through 180.degree., said spin echo is recorded and said excitation sequence is repeated. At least one magnetic field is applied to the target in a manner that the duration and/or amplitude of said magnetic field gradient are varied between various repetitions, so that the difference between the absolute values of time integral of a value following said 180.degree. pulse and a value preceding said 180.degree. pulse of said magnetic field gradient obtains a different value. This way, the use of bipolar current sources is avoided. The invention is well adaptable to recovering information quickly especially about a plurality of image planes from a three-dimensional target.

Abstract translation: 本发明涉及一种恢复关于靶的物质的核自旋或NMR信息的方法，例如放置在至少基本均匀的磁场中的人体，通过优选偏离核的射频磁场激发目标的所需部分 通过90°的磁化，通过利用目标体积的第二次激发产生所谓的自旋回波，其优选地将核磁化强度偏移180°，记录所述自旋回波并重复所述激发序列。 至少一个磁场以使得所述磁场梯度的持续时间和/或振幅在各种重复之间变化的方式施加到目标，使得在所述180°脉冲之后的值的时间积分的绝对值之间的差 并且所述磁场梯度的所述180°脉冲之前的值获得不同的值。 这样，避免使用双极电流源。 本发明适用于快速恢复信息，特别是关于来自三维目标的多个图像平面。

公开(公告)号：US4543959A

公开(公告)日：1985-10-01

申请号：US695403

申请日：1985-01-25

Applicant: Raimo Sepponen

Inventor： Raimo Sepponen

IPC: A61B8/00 ,  A61B5/055 ,  A61B8/08 ,  G01R33/28 ,  G01R33/38 ,  G01R33/48 ,  A61B5/04

CPC classification number: G01R33/4814 ,  A61B5/055 ,  A61B5/416 ,  A61B8/08 ,  A61B8/5238 ,  G01R33/28 ,  G01R33/381

Abstract: The invention relates to a diagnosis apparatus for simultaneously collecting information on tissue structure and tissue quality from a target, e.g. human body to be examined. The apparatus of the invention comprises means (1) for emitting ultrasonic pulses and for detecting and registering reflections from the interfaces between tissues in target area (16) determined by said means, and means (10) for processing the information obtained from a target area by means of said ultrasonic pulses as well as means (8) for visualizing the information for finding and localizing tissue area to be characterized.The apparatus is further provided with elements (2, 3, 11, 12, 13) for collecting tissue identification information by means of a nuclear magnetic resonance or NMR-phenomenon from target to be examined in manner that the tissue identification area (19) sensitive to nuclear magnetic resonanse is arranged to be produced in said target area (16) localized and visualized by ultrasonic pulses for immediate analysis on said tissue area to be characterized.

Abstract translation: 本发明涉及一种诊断装置，用于同时收集来自目标的组织结构和组织质量的信息，例如， 人体要检查。 本发明的装置包括用于发射超声波脉冲并用于检测和记录来自由所述装置确定的目标区域（16）中的组织之间的界面的反射的装置（1），以及用于处理从目标区域获得的信息的装置（10） 通过所述超声波脉冲以及用于可视化用于发现和定位要表征的组织区域的信息的装置（8）。 该装置还设置有用于通过核组织识别区域（19）敏感的待检查目标的核磁共振或核磁共振现象来收集组织识别信息的元件（2,3,11,12,13） 核磁共振被布置成在所述目标区域（16）中产生，其通过超声脉冲进行局部化和可视化，以便在要表征的所述组织区域上立即分析。

公开(公告)号：US07667612B2

公开(公告)日：2010-02-23

申请号：US10568545

申请日：2004-08-20

Applicant: Raimo Sepponen

Inventor： Raimo Sepponen

IPC: G08B21/00 ,  G01B7/16 ,  G01L1/00

CPC classification number: G08B21/028 ,  G08B13/10 ,  G08B21/0283 ,  G08B21/0453 ,  G08B21/22

Abstract: A method and an arrangement to monitor localization, movement, and properties of an object, such as human body. An excitation signal is connected to a first division of selected conductors of a transducer which includes a distribution of conductors such as a matrix. A first signal including information about coupling impedance between a first and a second selected division of conductors is derived from a coupling of the excitation signal between the first and the second selected divisions of conductors of said transducer. The object is monitored by studying changes of the coupling impedance caused by the object to be monitored during subsequent repeated cycles of the above mentioned steps.

Abstract translation: 用于监测物体（例如人体）的定位，运动和性质的方法和装置。 激励信号连接到包括诸如矩阵的导体分布的换能器的选定导体的第一分割。 从所述换能器的导体的第一和第二选择的分割线之间的激励信号的耦合导出包括关于第一和第二选择的导体分割之间的耦合阻抗的信息的第一信号。 通过在随后的上述步骤的重复循环中研究由待监测对象引起的耦合阻抗的变化来监视该对象。

公开(公告)号：US20070008145A1

公开(公告)日：2007-01-11

申请号：US10568545

申请日：2004-08-20

Applicant: Raimo Sepponen

Inventor： Raimo Sepponen

IPC: G08B23/00

CPC classification number: G08B21/028 ,  G08B13/10 ,  G08B21/0283 ,  G08B21/0453 ,  G08B21/22

Abstract: The invention relates to a method and an arrangement to monitor localisation, movement and properties of an object (O), such as human body according to the invention an excitation signal (HS) is connected to first division of conductor of a transducer (TRANSDUCER MATRIX) which includes a distribution of conductor such as a matrix, a signal (AS) is derived from second division of conductor of said transducer (TRANSDUCER MATRIX) and said operations are to be repeated with other divisions of the transducer (TRANSDUCER MATRIX) and based on information related to coupling between divisions said monitoring will be performed.

Abstract translation: 本发明涉及一种监测根据本发明的诸如人体的物体（O）的定位，运动和性质的方法和装置，激励信号（HS）连接到换能器的导体的第一分割（TRANSDUCER MATRIX ），其包括诸如矩阵的导体的分布，信号（AS）是从所述换能器（TRANSDUCER MATRIX）的导体的第二除法导出的，并且所述操作将与换能器（TRANSDUCER MATRIX）的其它部分重复并基于 关于与分部之间的耦合相关的信息，表示将执行监视。

公开(公告)号：US5227723A

公开(公告)日：1993-07-13

申请号：US580818

申请日：1990-09-11

Applicant: Raimo Sepponen

Inventor： Raimo Sepponen

IPC: G01R33/56 ,  G01R33/561

CPC classification number: G01R33/56 ,  G01R33/561

Abstract: The invention relates to a method based on the NMR phenomenon and magnetic resonance imaging techniques for the examination of an object, such as a human body, an animal or a tree trunk, wherein the image-related information is collected by effecting several times the operations required by a so-called imaging sequence, wherein the excitation procedure is followed by coupling across the object a magnetic field gradient, a so-called phase-encoding gradient, produced as a resultant of one or more divergent gradient fields, and thereafter a so-called read-out gradient during which a nuclear magnetic resonance signal is collected. One or more component gradient fields of said phase-encoding gradient produce a read-out gradient in some of the sequence repetition times.

Abstract translation: 本发明涉及一种基于NMR现象的方法和用于检查诸如人体，动物或树干的物体的磁共振成像技术，其中通过进行几次操作来收集图像相关信息 所谓的成像序列所要求的，其中激励过程之后是跨越物体耦合磁场梯度，即所谓的相位编码梯度，作为一个或多个发散梯度场的结果产生，然后如此 其中收集了一个核磁共振信号。 所述相位编码梯度的一个或多个分量梯度场在一些序列重复次数中产生读出梯度。

公开(公告)号：US5218964A

公开(公告)日：1993-06-15

申请号：US738834

申请日：1991-08-01

Applicant: Raimo Sepponen

Inventor： Raimo Sepponen

IPC: A61B5/055 ,  G01R33/28 ,  G01R33/58 ,  G01R33/62

CPC classification number: G01R33/28 ,  A61B5/055 ,  G01R33/58 ,  G01R33/62 ,  G01R33/287

Abstract: A method for providing reference markers in magnetic resonance (MR) images which are highly discernible and accurately defined in the MR image. The method may be carried out with short imaging times. The reference markers have a volume containing NMR active nuclei and an electron spin resonance relaxant During the MRI examination procedure of an object, electron spin resonance energy is supplied to the reference markers to amplify the NMR signal from the markers by dynamic nuclear polarization. The amplification improves the visibility of the reference marker in the MR image of the object while permitting the size of the marker to be reduced to improve the accuracy by which other features appearing in the image may be located by reference to the markers. The reference markers may be used to locate anatomical features in a portion of a human body undergoing MRI examination.

Abstract translation: 一种用于在磁共振（MR）图像中提供参考标记的方法，其在MR图像中高度可辨别并且被精确地定义。 该方法可以以短的成像时间进行。 参考标记具有包含NMR活性核和电子自旋共振松弛剂的体积在物体的MRI检查过程中，将电子自旋共振能量提供给参考标记，以通过动态核极化从标记物扩增NMR信号。 放大改善了对象的MR图像中的参考标记的可视性，同时允许减小标记的大小以提高通过参考标记来出现在图像中的其他特征的精度。 参考标记可用于定位经历MRI检查的人体的一部分中的解剖特征。