公开(公告)号：US08591562B2

公开(公告)日：2013-11-26

申请号：US12629863

申请日：2009-12-02

申请人： Raimondo D'Ambrosio ,  Matthew Smyth ,  Steven Mark Rothman ,  John W. Miller ,  Jason Fender

发明人： Raimondo D'Ambrosio ,  Matthew Smyth ,  Steven Mark Rothman ,  John W. Miller ,  Jason Fender

IPC分类号： A61F7/12

CPC分类号： A61F7/12 ,  A61F2007/0002 ,  A61F2007/0096 ,  A61F2007/0247

摘要： A device for cooling the central nervous system (e.g., the brain) is disclosed that is specifically designed to provide cooling of an injured central nervous system for neuroprotective, antiepileptogenic, and/or antiepileptic treatments. In one embodiment, a portion of the cooling device is placed in a recess formed by removal of a portion of a patient's skull. An embedded heat-collecting portion of the cooling device is formed to fit in the location of the formed recess and a thermally conductive material of the heat-collecting portion is placed adjacent the dura mater to provide the desired degree of cooling. A heat-dissipating external plate is in thermal contact with the internal plate, and can be selectively sized according to a specific purpose.

摘要翻译： 公开了一种用于冷却中枢神经系统（例如脑）的装置，其特别设计为提供用于神经保护，抗癫痫发生和/或抗癫痫治疗的受损中枢神经系统的冷却。 在一个实施例中，冷却装置的一部分被放置在通过去除患者头骨的一部分而形成的凹部中。 冷却装置的嵌入式集热部形成为配合在所形成的凹部的位置，并且集热部的导热材料配置在硬膜附近，以提供所需的冷却程度。 散热外板与内板热接触，可根据具体目的选择尺寸。

公开(公告)号：US20100312318A1

公开(公告)日：2010-12-09

申请号：US12629863

申请日：2009-12-02

申请人： Raimondo D'Ambrosio ,  Matthew Smyth ,  Steven Mark Rothman ,  John W. Miller

发明人： Raimondo D'Ambrosio ,  Matthew Smyth ,  Steven Mark Rothman ,  John W. Miller

IPC分类号： A61F7/12

CPC分类号： A61F7/12 ,  A61F2007/0002 ,  A61F2007/0096 ,  A61F2007/0247

摘要： A device for cooling the central nervous system (e.g., the brain) is disclosed that is specifically designed to provide cooling of an injured central nervous system for neuroprotective, antiepileptogenic, and/or antiepileptic treatments. In one embodiment, a portion of the cooling device is placed in a recess formed by removal of a portion of a patient's skull. An embedded heat-collecting portion of the cooling device is formed to fit in the location of the formed recess and a thermally conductive material of the heat-collecting portion is placed adjacent the dura mater to provide the desired degree of cooling. A heat-dissipating external plate is in thermal contact with the internal plate, and can be selectively sized according to a specific purpose.

摘要翻译： 公开了一种用于冷却中枢神经系统（例如脑）的装置，其特别设计为提供用于神经保护，抗癫痫发生和/或抗癫痫治疗的受损中枢神经系统的冷却。 在一个实施例中，冷却装置的一部分被放置在通过去除患者头骨的一部分而形成的凹部中。 冷却装置的嵌入式集热部形成为配合在所形成的凹部的位置，并且集热部的导热材料配置在硬膜附近，以提供所需的冷却程度。 散热外板与内板热接触，可根据具体目的选择尺寸。

公开(公告)号：US09522081B2

公开(公告)日：2016-12-20

申请号：US13482903

申请日：2012-05-29

申请人： Raimondo D'Ambrosio ,  Jason Fender ,  Jeffrey Ojemann ,  John W. Miller ,  Matthew Smyth ,  Steven M. Rothman

发明人： Raimondo D'Ambrosio ,  Jason Fender ,  Jeffrey Ojemann ,  John W. Miller ,  Matthew Smyth ,  Steven M. Rothman

IPC分类号： A61F7/12 ,  A61F7/00 ,  A61F7/02

CPC分类号： A61F7/12 ,  A61F7/10 ,  A61F2007/0002 ,  A61F2007/0096 ,  A61F2007/0247 ,  A61F2007/108 ,  A61F2007/126

摘要： Passive prosthetic devices for focally cooling a brain and methods for inhibiting seizures are disclosed. The prosthetic devices replace a thermally insulating bone flap with a thermally conductive insert having an inner surface that contacts the relatively warm meninges or brain and an outer surface that contacts the relatively cool scalp. In an embodiment, the prosthesis is unitary; in another, a biocompatible casing is filled with a highly conductive core; in another, a filled polymer block is attached to a plate; and in another, the bone flap is filled with a conductive polymer. In one embodiment, a filled polymer containing elements that exhibit the magnetocaloric effect provide heat transfer that can be enhanced by application of a suitable magnetic field. Focal cooling as low as 1.2° C. has been found effective at inhibiting seizures.

摘要翻译： 公开了用于灶脑冷却的被动修复装置和抑制癫痫发作的方法。 假体装置用具有接触相对温暖的脑膜或脑的内表面的导热插入物和接触相对较冷的头皮的外表面替换绝热骨瓣。 在一个实施例中，假体是一体的; 在另一个中，生物相容性壳体填充有高度导电的芯; 另一方面，将填充的聚合物嵌段连接到板上; 另一方面，骨折片填充有导电聚合物。 在一个实施方案中，含有表现出磁热效应的元素的填充聚合物提供可以通过施加合适的磁场而增强的热传递。 发现低至1.2℃的局部冷却有效抑制癫痫发作。

公开(公告)号：US20120290052A1

公开(公告)日：2012-11-15

申请号：US13482903

申请日：2012-05-29

申请人： Raimondo D'Ambrosio ,  Jason Fender ,  Jeffrey Ojemann ,  John W. Miller

发明人： Raimondo D'Ambrosio ,  Jason Fender ,  Jeffrey Ojemann ,  John W. Miller

IPC分类号： A61F7/12 ,  B82Y5/00

CPC分类号： A61F7/12 ,  A61F7/10 ,  A61F2007/0002 ,  A61F2007/0096 ,  A61F2007/0247 ,  A61F2007/108 ,  A61F2007/126

摘要： Passive prosthetic devices for focally cooling a brain and methods for inhibiting seizures are disclosed. The prosthetic devices replace a thermally insulating bone flap with a thermally conductive insert having an inner surface that contacts the relatively warm meninges or brain and an outer surface that contacts the relatively cool scalp. In an embodiment, the prosthesis is unitary; in another, a biocompatible casing is filled with a highly conductive core; in another, a filled polymer block is attached to a plate; and in another, the bone flap is filled with a conductive polymer. In one embodiment, a filled polymer containing elements that exhibit the magnetocaloric effect provide heat transfer that can be enhanced by application of a suitable magnetic field. Focal cooling as low as 1.2° C. has been found effective at inhibiting seizures.

摘要翻译： 公开了用于灶脑冷却的被动修复装置和抑制癫痫发作的方法。 假体装置用具有接触相对温暖的脑膜或脑的内表面的导热插入物和接触相对较冷的头皮的外表面替换绝热骨瓣。 在一个实施例中，假体是一体的; 在另一个中，生物相容性壳体填充有高度导电的芯; 另一方面，将填充的聚合物嵌段连接到板上; 另一方面，骨折片填充有导电聚合物。 在一个实施方案中，含有表现出磁热效应的元素的填充聚合物提供可以通过施加合适的磁场而增强的热传递。 发现低至1.2℃的局部冷却有效抑制癫痫发作。