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1.发明授权Methods of making and using a cell penetrating peptide for enhanced delivery of nucleic acids, proteins, drugs, and adenovirus to tissues and cells, and compositions and kits 有权制备和使用细胞穿透肽以增强核酸，蛋白质，药物和腺病毒对组织和细胞的传递的方法以及组合物和试剂盒公开(公告)号：US08778886B2
公开(公告)日：2014-07-15
申请号：US12714106
申请日：2010-02-26
IPC分类号： A61K38/00 , A61K47/00 , A61K38/16 , A61K38/10 , A61K38/08 , A61K39/385 , A61K38/04 , A61M31/00 , A61P9/10 , A61P27/02 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00
CPC分类号： A61K47/6929 , A61K47/60 , A61K47/645
摘要： A peptide-POD with ability to penetrate and deliver fluorophores, siRNA, DNA and quantum dots to cells in culture and retinal and ocular tissues in vivo is provided herein. POD couples to adenovirus vectors, enhancing tropism for certain cells, potentially providing a safer and more efficacious method to deliver molecules to ocular and other tissues in vivo. POD constructs are therapeutic delivery vehicles for treating cells and tissues, including ocular cells and tissues suffering from retinal degeneration.
摘要翻译： 本文提供了能够在体内将荧光团，siRNA，DNA和量子点传递到培养物和视网膜和眼组织中的细胞的能力的肽-POD。 POD与腺病毒载体耦合，增强某些细胞的嗜性，潜在地提供了一种更安全，更有效的方法来将分子递送到眼睛和其他组织体内。 POD构建体是用于治疗细胞和组织的治疗性递送载体，包括眼细胞和患有视网膜变性的组织。
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2.发明申请Methods of making and using a cell penetrating peptide for enhanced delivery of nucleic acids, proteins, drugs, and adenovirus to tissues and cells, and compositions and kits 有权制备和使用细胞穿透肽以增强核酸，蛋白质，药物和腺病毒对组织和细胞的传递的方法以及组合物和试剂盒公开(公告)号：US20100209447A1
公开(公告)日：2010-08-19
申请号：US12714106
申请日：2010-02-26
IPC分类号： A61K39/385 , A61K31/7088 , A61K31/713 , A61K38/02 , A61K31/70 , A61K38/16 , C12N5/00 , A61P27/02
CPC分类号： A61K47/6929 , A61K47/60 , A61K47/645
摘要： A peptide-POD with ability to penetrate and deliver fluorophores, siRNA, DNA and quantum dots to cells in culture and retinal and ocular tissues in vivo is provided herein. POD couples to adenovirus vectors, enhancing tropism for certain cells, potentially providing a safer and more efficacious method to deliver molecules to ocular and other tissues in vivo. POD constructs are therapeutic delivery vehicles for treating cells and tissues, including ocular cells and tissues suffering from retinal degeneration.
摘要翻译： 本文提供了能够在体内将荧光团，siRNA，DNA和量子点传递到培养物和视网膜和眼组织中的细胞的能力的肽-POD。 POD与腺病毒载体耦合，增强某些细胞的嗜性，潜在地提供了一种更安全，更有效的方法来将分子递送到眼睛和其他组织体内。 POD构建体是用于治疗细胞和组织的治疗性递送载体，包括眼细胞和患有视网膜变性的组织。
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