专利检索 ap:("Rajinder Singh" OR "Catherine Sylvain" OR "Sacha Holland" OR "Jing Zhang" OR "John J. Partridge" OR "Jeffrey Clough" OR "Ankush Argade") AND inv:"Sacha Holland" 第 1 页

1.

发明申请
TRIAZOLE DERIVATIVES USEFUL AS AXL INHIBITORS 有权
标题翻译：三唑衍生物有用作AXL抑制剂

公开(公告)号：US20110082131A1

公开(公告)日：2011-04-07

申请号：US12965545

申请日：2010-12-10

申请人： Rajinder Singh , Catherine Sylvain , Sacha Holland , Jing Zhang , John J. Partridge , Jeffrey Clough , Ankush Argade

发明人： Rajinder Singh , Catherine Sylvain , Sacha Holland , Jing Zhang , John J. Partridge , Jeffrey Clough , Ankush Argade

IPC分类号： A61K31/55 , A61K31/4196 , A61K31/5377 , A61K31/454 , A61K31/496 , A61K31/541 , A61K31/422 , A61K31/433 , A61K31/427 , A61K31/538 , A61K31/4709 , A61P35/00 , A61P19/02 , A61P17/06 , A61P3/10 , A61P13/12 , A61P27/12

CPC分类号： C07D403/12 , C07D249/14 , C07D405/12 , C07D413/12 , C07D417/12

摘要： Methods of using triazole derivatives in treating diseases or conditions associated with Axl catalytic activity are disclosed.

摘要翻译： 公开了使用三唑衍生物治疗与Axl催化活性有关的疾病或病症的方法。

2.

发明授权
Triazole derivatives useful as Axl inhibitors 有权
标题翻译：用作Axl抑制剂的三唑衍生物

公开(公告)号：US07884119B2

公开(公告)日：2011-02-08

申请号：US11518550

申请日：2006-09-07

申请人： Rajinder Singh , Catherine Sylvain , Sacha Holland , Jing Zhang , John J. Partridge , Jeffrey Clough , Ankush Argade

发明人： Rajinder Singh , Catherine Sylvain , Sacha Holland , Jing Zhang , John J. Partridge , Jeffrey Clough , Ankush Argade

IPC分类号： A61K31/41 , C07D249/00

CPC分类号： C07D403/12 , C07D249/14 , C07D405/12 , C07D413/12 , C07D417/12

摘要： Triazole derivatives and pharmaceutical compositions containing the derivatives are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine kinase Axl. Methods of using the derivatives in treating diseases or conditions associated with Axl catalytic activity are also disclosed.

摘要翻译： 公开了含有衍生物的三唑衍生物和药物组合物可用于抑制受体蛋白酪氨酸激酶Ax1的活性。还公开了使用衍生物治疗与Axl催化活性相关的疾病或病症的方法。

3.

发明授权
Triazole derivatives useful as Axl inhibitors 有权
标题翻译：用作Axl抑制剂的三唑衍生物

公开(公告)号：US08389557B2

公开(公告)日：2013-03-05

申请号：US12965545

申请日：2010-12-10

申请人： Rajinder Singh , Catherine Sylvain , Sacha Holland , Jing Zhang , John J. Partridge , Jeffrey Clough , Ankush Argade

发明人： Rajinder Singh , Catherine Sylvain , Sacha Holland , Jing Zhang , John J. Partridge , Jeffrey Clough , Ankush Argade

IPC分类号： A61K31/41 , C07D249/00

CPC分类号： C07D403/12 , C07D249/14 , C07D405/12 , C07D413/12 , C07D417/12

摘要： Methods of using triazole derivatives in treating diseases or conditions associated with Axl catalytic activity are disclosed.

摘要翻译： 公开了使用三唑衍生物治疗与Axl催化活性有关的疾病或病症的方法。

4.

发明申请
Triazole derivatives useful as Axl inhibitors 有权
标题翻译：用作Axl抑制剂的三唑衍生物

公开(公告)号：US20070213375A1

公开(公告)日：2007-09-13

申请号：US11518550

申请日：2006-09-07

申请人： Rajinder Singh , Catherine Sylvain , Sacha Holland , Jing Zhang , John Partridge , Jeffrey Clough , Ankush Argade

发明人： Rajinder Singh , Catherine Sylvain , Sacha Holland , Jing Zhang , John Partridge , Jeffrey Clough , Ankush Argade

IPC分类号： A61K31/4439 , A61K31/425 , A61K31/4196 , C07D403/02 , C07D417/02

CPC分类号： C07D403/12 , C07D249/14 , C07D405/12 , C07D413/12 , C07D417/12

摘要： Triazole derivatives and pharmaceutical compositions containing the derivatives are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine kinase Axl. Methods of using the derivatives in treating diseases or conditions associated with Axl catalytic activity are also disclosed.

摘要翻译： 公开了含有衍生物的三唑衍生物和药物组合物可用于抑制受体蛋白酪氨酸激酶Ax1的活性。还公开了使用衍生物治疗与Axl催化活性相关的疾病或病症的方法。

5.

发明授权
2,4-pyrimidinediamine compounds and their uses 有权
标题翻译： 2,4-嘧啶二胺化合物及其用途

公开(公告)号：US07550460B2

公开(公告)日：2009-06-23

申请号：US11782581

申请日：2007-07-24

申请人： Rajinder Singh , Ankush Argade , Donald Payan , Susan Molineaux , Sacha Holland , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Catherine Sylvain , Hui Li , Alexander Rossi

发明人： Rajinder Singh , Ankush Argade , Donald Payan , Susan Molineaux , Sacha Holland , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Catherine Sylvain , Hui Li , Alexander Rossi

IPC分类号： A61K31/535

CPC分类号： A61K31/505 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/5395 , A61K31/551 , A61K45/06 , C07D239/48 , C07D265/36 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D495/04 , C07D498/04 , C07D498/14 , C07F5/027

摘要： The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of diseases characterized by, caused by or associated with the release of chemical mediators via degranulation and other processes effected by activation of the IgE and/or IgG receptor signaling cascades.

摘要翻译： 本发明提供了抑制导致释放化学介质，中间体和合成化合物的方法的IgE和/或IgG受体信号级联的2,4-嘧啶二胺化合物和在多种情况下使用化合物的方法，包括在治疗和预防以IgE和/或IgG受体信号传导级联的活化作用通过脱颗粒和其它方法释放化学介质引起或与之相关的疾病。

6.

发明申请
2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES 有权

公开(公告)号：US20070293523A1

公开(公告)日：2007-12-20

申请号：US11539049

申请日：2006-10-05

申请人： Rajinder Singh , Ankush Argade , Donald Payan , Susan Molineaux , Sacha Holland , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Catherine Sylvain , Hui Li , Alexander Rossi

发明人： Rajinder Singh , Ankush Argade , Donald Payan , Susan Molineaux , Sacha Holland , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Catherine Sylvain , Hui Li , Alexander Rossi

IPC分类号： A61K31/505 , A61K31/506 , A61P43/00 , C07D239/02 , C12N5/02 , C12N9/99

CPC分类号： A61K31/505 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/5395 , A61K31/551 , A61K45/06 , C07D239/48 , C07D265/36 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D495/04 , C07D498/04 , C07D498/14 , C07F5/027

摘要： The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of diseases characterized by, caused by or associated with the release of chemical mediators via degranulation and other processes effected by activation of the IgE and/or IgG receptor signaling cascades.

7.

发明申请
2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES 审中-公开
标题翻译： 2,4-吡啶二胺化合物及其用途

公开(公告)号：US20070293522A1

公开(公告)日：2007-12-20

申请号：US11539041

申请日：2006-10-05

申请人： Rajinder SINGH , Ankush Argade , Donald Payan , Susan Molineaux , Sacha Holland , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Catherine Sylvain , Hui Li , Alexander Rossi

发明人： Rajinder SINGH , Ankush Argade , Donald Payan , Susan Molineaux , Sacha Holland , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Catherine Sylvain , Hui Li , Alexander Rossi

IPC分类号： A61K31/505 , A61K31/506 , A61P43/00 , C07D239/02 , C12N5/02 , C12N9/99

CPC分类号： A61K31/505 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/5395 , A61K31/551 , A61K45/06 , C07D239/48 , C07D265/36 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D495/04 , C07D498/04 , C07D498/14 , C07F5/027

摘要： The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of diseases characterized by, caused by or associated with the release of chemical mediators via degranulation and other processes effected by activation of the IgE and/or IgG receptor signaling cascades.

摘要翻译： 本发明提供了抑制导致释放化学介质，中间体和合成化合物的方法的IgE和/或IgG受体信号级联的2,4-嘧啶二胺化合物和在各种情况下使用化合物的方法，包括在治疗和预防以IgE和/或IgG受体信号传导级联的活化作用通过脱颗粒和其它方法释放化学介质引起或与之相关的疾病。

8.

发明申请
2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES 有权
标题翻译： 2,4-吡啶二胺化合物及其用途

公开(公告)号：US20080039622A1

公开(公告)日：2008-02-14

申请号：US11782581

申请日：2007-07-24

申请人： Rajinder SINGH , Ankush Argade , Donald Payan , Susan Molineaux , Sacha Holland , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Catherine Sylvain , Hui Li , Alexander Rossi

发明人： Rajinder SINGH , Ankush Argade , Donald Payan , Susan Molineaux , Sacha Holland , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Catherine Sylvain , Hui Li , Alexander Rossi

IPC分类号： C07D241/36 , C07D239/46 , C07D295/00

CPC分类号： A61K31/505 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/5395 , A61K31/551 , A61K45/06 , C07D239/48 , C07D265/36 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D495/04 , C07D498/04 , C07D498/14 , C07F5/027

摘要： The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of diseases characterized by, caused by or associated with the release of chemical mediators via degranulation and other processes effected by activation of the IgE and/or IgG receptor signaling cascades.

摘要翻译： 本发明提供了抑制导致释放化学介质，中间体和合成化合物的方法的IgE和/或IgG受体信号级联的2,4-嘧啶二胺化合物和在多种情况下使用化合物的方法，包括在治疗和预防以IgE和/或IgG受体信号传导级联的活化作用通过脱颗粒和其它方法释放化学介质引起或与之相关的疾病。