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    Self-preserved ophthalmic pharmaceutical compositions containing tobramycin
    2.
    发明申请
    Self-preserved ophthalmic pharmaceutical compositions containing tobramycin 审中-公开
    含有妥布霉素的自保眼用药物组合物

    公开(公告)号：US20060141059A1

    公开(公告)日：2006-06-29

    申请号：US11317261

    申请日：2005-12-23

    申请人： Masood Chowhan ,  Ernesto Castillo ,  Glenn Stafford ,  Rajni Jani ,  Haresh Bhagat

    发明人： Masood Chowhan ,  Ernesto Castillo ,  Glenn Stafford ,  Rajni Jani ,  Haresh Bhagat

    IPC分类号： A61K31/7034 ,  A61K33/22

    CPC分类号： A61K31/7034 ,  A61K33/22 ,  A61K2300/00

    摘要： Self-preserved, multi-dose ophthalmic compositions containing tobramycin are described. The compositions do not contain a conventional antimicrobial preservative, such as benzalkonium chloride. Rather, the compositions are self-preserved as a result of the inherent antimicrobial activity of tobramycin. The compositions preferably also contain either boric acid or, more preferably, a borate/polyol complex selected from the group consisting of borate/propylene glycol, borate/glycerol, and combinations thereof.

    摘要翻译： 描述了含有妥布霉素的自保留的多剂量眼用组合物。 组合物不含常规抗菌防腐剂，例如苯扎氯铵。 相反，由于妥布霉素的固有抗微生物活性，组合物是自我保存的。 组合物还优选还含有硼酸或更优选选自硼酸盐/丙二醇，硼酸盐/甘油及其组合的硼酸盐/多元醇络合物。

    USE OF OCULOSURFACE SELECTIVE GLUCOCORTICOID IN THE TREATMENT OF DRY EYE
    5.
    发明申请
    USE OF OCULOSURFACE SELECTIVE GLUCOCORTICOID IN THE TREATMENT OF DRY EYE 审中-公开
    用于治疗干眼症中的表面选择性胆固醇的用途

    公开(公告)号：US20080096852A1

    公开(公告)日：2008-04-24

    申请号：US11925178

    申请日：2007-10-26

    申请人： John YANNI ,  Daniel Gamache ,  Steven Miller ,  Ernesto Castillo

    发明人： John YANNI ,  Daniel Gamache ,  Steven Miller ,  Ernesto Castillo

    IPC分类号： A61K31/575 ,  A61P27/02

    CPC分类号： A61K31/575 ,  A61K9/0048 ,  A61K31/57 ,  A61K31/573 ,  A61K47/12 ,  A61K47/18 ,  A61K47/186 ,  A61K47/26 ,  A61K47/32

    摘要： Topical ophthalmic compositions and methods for treating dry eye are described. The compositions and methods of the invention are based on the finding that the oculosurface selective properties of the glucocorticoid rimexolone make this anti-inflammatory agent particularly well-suited for treating dry eye. As a result of the limited ability of rimexolone to penetrate the cornea, a high portion of the drug remains on the surface of the eye, which is the primary locus of the inflammatory conditions associated with dry eye. This enables a very low concentration of drug to be utilized, which in turn reduces the potential for elevations of intraocular pressure and cataract formation.

    摘要翻译： 描述了用于治疗干眼症的局部眼用组合物和方法。 本发明的组合物和方法基于这样的发现，即糖皮质激素瑞ol酮的眼部表面选择性使该抗炎剂特别适合于治疗干眼症。 由于赖ol酮渗透角膜的能力有限，药物的大部分残留在眼睛的表面上，这是与干眼症相关的炎性病症的主要位点。 这使得能够使用非常低浓度的药物，这又降低了眼压升高和白内障形成的可能性。

    Use of oculosurface selective glucocorticoid in the treatment of dry eye
    6.
    发明申请
    Use of oculosurface selective glucocorticoid in the treatment of dry eye 审中-公开
    使用ocuoseurface选择性糖皮质激素治疗干眼症

    公开(公告)号：US20060058277A1

    公开(公告)日：2006-03-16

    申请号：US11250262

    申请日：2005-10-14

    申请人： John Yanni ,  Daniel Gamache ,  Steven Miller ,  Ernesto Castillo

    发明人： John Yanni ,  Daniel Gamache ,  Steven Miller ,  Ernesto Castillo

    IPC分类号： A61K31/573

    CPC分类号： A61K31/575 ,  A61K9/0048 ,  A61K31/57 ,  A61K31/573 ,  A61K47/12 ,  A61K47/18 ,  A61K47/186 ,  A61K47/26 ,  A61K47/32

    摘要： Topical ophthalmic compositions and methods for treating dry eye are described. The compositions and methods of the invention are based on the finding that the oculosurface selective properties of the glucocorticoid rimexolone make this anti-inflammatory agent particularly well-suited for treating dry eye. As a result of the limited ability of rimexolone to penetrate the cornea, a high portion of the drug remains on the surface of the eye, which is the primary locus of the inflammatory conditions associated with dry eye. This enables a very low concentration of drug to be utilized, which in turn reduces the potential for elevations of intraocular pressure and cataract formation.

    摘要翻译： 描述了用于治疗干眼症的局部眼用组合物和方法。 本发明的组合物和方法基于这样的发现，即糖皮质激素瑞ol酮的眼部表面选择性使该抗炎剂特别适合于治疗干眼症。 由于赖ol酮渗透角膜的能力有限，药物的大部分残留在眼睛的表面上，这是与干眼症相关的炎性病症的主要位点。 这使得能够使用非常低浓度的药物，这又降低了眼压升高和白内障形成的可能性。