公开(公告)号：US06652594B2

公开(公告)日：2003-11-25

申请号：US10099425

申请日：2002-03-14

申请人： Ralph T. Francis ,  Qing Hong Zhao ,  Amy DeSmith ,  B. Nicholas Oray

发明人： Ralph T. Francis ,  Qing Hong Zhao ,  Amy DeSmith ,  B. Nicholas Oray

IPC分类号： A61F236

CPC分类号： A61L27/3687 ,  A61L27/227 ,  A61L27/24 ,  A61L27/3604 ,  A61L27/362 ,  A61L27/3629 ,  A61L31/043 ,  A61L31/044

摘要： A non-crosslinked, decellularized and purified mammalian tissue (e.g., bovine pericardium) having particular use as an implantable resorbable material. The material is treated by alkylating its primary amine groups in a manner sufficient to reduce the antigenicity of the tissue, permitting the treated tissue to be used in vivo and without crosslinking, and in turn, permitting it to be resorbable. The material can be used in surgical repair of soft tissue deficiencies for a certain period of time while the implant itself is gradually remodeled or absorbed by the host. Also provided are a method of preparing such a material, as well as a method of using such a material for surgical repair.

公开(公告)号：US06312474B1

公开(公告)日：2001-11-06

申请号：US09396279

申请日：1999-09-15

申请人： Ralph T. Francis ,  Qing Hong Zhao ,  Amy Desmith ,  B. Nicholas Oray

发明人： Ralph T. Francis ,  Qing Hong Zhao ,  Amy Desmith ,  B. Nicholas Oray

IPC分类号： A61F202

CPC分类号： A61L27/3687 ,  A61L27/227 ,  A61L27/24 ,  A61L27/3604 ,  A61L27/362 ,  A61L27/3629 ,  A61L31/043 ,  A61L31/044

摘要： A non-crosslinked, decellularized and purified mammalian tissue (e.g., bovine pericardium) having particular use as an implantable resorbable material. The material is treated by alkylating its primary amine groups in a manner sufficient to reduce the antigenicity of the tissue, permitting the treated tissue to be used in vivo and without crosslinking, and in turn, permitting it to be resorbable. The material can be used in surgical repair of soft tissue deficiencies for a certain period of time while the implant itself is gradually remodeled or absorbed by the host. Also provided are a method of preparing such a material, as well as a method of using such a material for surgical repair.

摘要翻译： 非交联，脱细胞和纯化的哺乳动物组织（例如，牛心包膜），其特别用作可植入的可再吸收材料。 通过以足以降低组织的抗原性的方式烷基化其伯胺基团来处理该材料，允许经处理的组织在体内和不交联下使用，从而使其可再吸收。 该材料可用于软组织缺损的手术修复一段时间，同时植入物本身被主体逐渐改造或吸收。 还提供了制备这种材料的方法，以及使用这种材料进行外科修复的方法。

公开(公告)号：US5945340A

公开(公告)日：1999-08-31

申请号：US227956

申请日：1999-01-11

申请人： Ralph T. Francis ,  Alan M. Johnson

发明人： Ralph T. Francis ,  Alan M. Johnson

IPC分类号： G01N33/80 ,  G01N33/96 ,  G01N33/49

CPC分类号： G01N33/96 ,  G01N33/80 ,  G01N2496/05 ,  Y10S435/81 ,  Y10T436/10 ,  Y10T436/101666 ,  Y10T436/25 ,  Y10T436/25125 ,  Y10T436/2525 ,  Y10T436/25375

摘要： A pre-determined concentration of stabilized, maturation-arrested porcine reticulocytes in a red blood cell base, useful as a reticulocyte control composition. The composition can be provided in the form of a concentrated reticulocyte composition, to be diluted to a desired final reticulocyte concentration at the time of use. The composition can also be provided in the form of a diluted, ready-to-use control composition. Also included is a method of preparing such a composition, the method involving sequential steps of forming and sedimenting Rouleaux bodies.

摘要翻译： 在红细胞基质中预定浓度的稳定化成熟的猪网织红细胞，可用作网织红细胞控制组合物。 组合物可以以浓缩的网织红细胞组合物的形式提供，在使用时稀释至所需的最终网织红细胞浓度。 组合物也可以以稀释的即用型控制组合物的形式提供。 还包括制备这种组合物的方法，该方法包括形成和沉降Rouleaux体的顺序步骤。

公开(公告)号：US5736402A

公开(公告)日：1998-04-07

申请号：US695515

申请日：1996-08-12

申请人： Ralph T. Francis ,  Alan M. Johnson

发明人： Ralph T. Francis ,  Alan M. Johnson

IPC分类号： G01N33/80 ,  G01N33/96 ,  G01N33/49

CPC分类号： G01N33/96 ,  G01N33/80 ,  G01N2496/05 ,  Y10S435/81 ,  Y10T436/10 ,  Y10T436/101666 ,  Y10T436/25 ,  Y10T436/25125 ,  Y10T436/2525 ,  Y10T436/25375

摘要： A pre-determined concentration of stabilized, maturation-arrested porcine reticulocytes in a red blood cell base, useful as a reticulocyte control composition. The composition can be provided in the form of a concentrated reticulocyte composition, to be diluted to a desired final reticulocyte concentration at the time of use. The composition can also be provided in the form of a diluted, ready-to-use control composition. Also included is a method of preparing such a composition, the method involving sequential steps of forming and sedimenting Rouleaux bodies.

公开(公告)号：US5858789A

公开(公告)日：1999-01-12

申请号：US55371

申请日：1998-04-06

申请人： Ralph T. Francis ,  Alan M. Johnson

发明人： Ralph T. Francis ,  Alan M. Johnson

IPC分类号： G01N33/80 ,  G01N33/96 ,  G01N33/49

CPC分类号： G01N33/96 ,  G01N33/80 ,  G01N2496/05 ,  Y10S435/81 ,  Y10T436/10 ,  Y10T436/101666 ,  Y10T436/25 ,  Y10T436/25125 ,  Y10T436/2525 ,  Y10T436/25375

摘要： A pre-determined concentration of stabilized, maturation-arrested porcine reticulocytes in a red blood cell base, useful as a reticulocyte control composition. The composition can be provided in the form of a concentrated reticulocyte composition, to be diluted to a desired final reticulocyte concentration at the time of use. The composition can also be provided in the form of a diluted, ready-to-use control composition. Also included is a method of preparing such a composition, the method involving sequential steps of forming and sedimenting Rouleaux bodies.

摘要翻译： 在红细胞基质中预定浓度的稳定化成熟的猪网织红细胞，可用作网织红细胞控制组合物。 组合物可以以浓缩的网织红细胞组合物的形式提供，在使用时被稀释至所需的最终网织红细胞浓度。 组合物也可以以稀释的即用型控制组合物的形式提供。 还包括制备这种组合物的方法，该方法包括形成和沉降Rouleaux体的顺序步骤。

公开(公告)号：US5752965A

公开(公告)日：1998-05-19

申请号：US734113

申请日：1996-10-21

申请人： Ralph T. Francis ,  Mark E. Hughes ,  Anne E. Claeson ,  Joel Cooper

发明人： Ralph T. Francis ,  Mark E. Hughes ,  Anne E. Claeson ,  Joel Cooper

IPC分类号： A61B17/11 ,  A61B17/00 ,  A61B17/072 ,  A61B17/10

CPC分类号： A61B17/07207 ,  A61B17/00491 ,  A61B17/07292 ,  A61B2017/00004

摘要： An apparatus and method for providing reinforced surgical fastener suture lines to prevent tissue tearing and fluid leakage following the creation of an anastomosis, the closing of margins following the removal of diseased tissue, and/or the ligating and dividing of individual blood vessels. A retainer assembly is provided having an alignment frame and a pressure equalization member. The alignment frame includes an internally disposed receiving area for housing the pressure equalization member and a pair of guide channels disposed in fluid communication with the receiving area for guiding the jaw members of a surgical fastener applying device into contact with pledget material disposed within the receiving area. Any number of surgical fastener applying devices may be retrofitted to provide reinforced surgical fastener suture lines by applying an adhesive along the length of the pledget material, positioning the jaw members of a surgical fastener applying device within the guide channels, and closing the surgical fastener applying device such that the jaw members are brought into compressed contact with the adhesive-laden pledget material. The surgical fastener applying device may then be opened with the pledget material releasibly attached to the jaw members, the jaw members positioned about a section of body tissue, and the surgical fastener applying device fired to create a reinforced suture line boasting reduced tissue tearing and reduced fluid leakage.

摘要翻译： 一种用于提供加强手术紧固件缝线的装置和方法，以防止在产生吻合之后的组织撕裂和流体泄漏，在移除患病组织之后关闭边缘，和/或单独血管的结扎和分开。 提供具有对准框架和压力均衡构件的保持器组件。 对准框架包括用于容纳压力平衡构件的内部设置的容纳区域和与接收区域流体连通地布置的一对引导通道，用于引导手术紧固件施加装置的钳口构件与布置在接收区域内的抹灰材料接触 。 任何数量的手术紧固件施加装置可以被改进以通过沿着所述绒毛材料的长度施加粘合剂来将增强的外科紧固件缝合线提供，以将手术紧固件施加装置的钳口构件定位在引导通道内，并且关闭手术紧固件施加 装置，使得钳口构件与粘合剂填充材料压缩接触。 手术紧固件施加装置然后可以打开，其中可释放地附接到钳口构件的钳形材料，夹钳构件围绕身体组织的一部分定位，并且手术紧固件施加装置被点燃以产生加强的缝合线，其具有减少的组织撕裂并减少 流体泄漏。