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公开(公告)号：US5858789A
公开(公告)日：1999-01-12
申请号：US55371
申请日：1998-04-06
申请人： Ralph T. Francis , Alan M. Johnson
发明人： Ralph T. Francis , Alan M. Johnson
CPC分类号： G01N33/96 , G01N33/80 , G01N2496/05 , Y10S435/81 , Y10T436/10 , Y10T436/101666 , Y10T436/25 , Y10T436/25125 , Y10T436/2525 , Y10T436/25375
摘要： A pre-determined concentration of stabilized, maturation-arrested porcine reticulocytes in a red blood cell base, useful as a reticulocyte control composition. The composition can be provided in the form of a concentrated reticulocyte composition, to be diluted to a desired final reticulocyte concentration at the time of use. The composition can also be provided in the form of a diluted, ready-to-use control composition. Also included is a method of preparing such a composition, the method involving sequential steps of forming and sedimenting Rouleaux bodies.
摘要翻译： 在红细胞基质中预定浓度的稳定化成熟的猪网织红细胞，可用作网织红细胞控制组合物。 组合物可以以浓缩的网织红细胞组合物的形式提供，在使用时被稀释至所需的最终网织红细胞浓度。 组合物也可以以稀释的即用型控制组合物的形式提供。 还包括制备这种组合物的方法，该方法包括形成和沉降Rouleaux体的顺序步骤。
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公开(公告)号：US06444471B1
公开(公告)日：2002-09-03
申请号：US09419991
申请日：1999-10-18
申请人： Alan M. Johnson
发明人： Alan M. Johnson
IPC分类号： G01N3100
CPC分类号： G01N33/96 , Y10S435/81 , Y10T436/10 , Y10T436/101666 , Y10T436/2525
摘要： A control composition, and method of preparing a control composition, that includes stabilized, maturation-arrested reticulocytes, and a complete blood count base including mature erythrocytes, stabilized white cells and stabilized platelets, or analogs thereof.
摘要翻译： 控制组合物和制备对照组合物的方法，其包括稳定的，成熟的网织红细胞，以及包括成熟的红细胞，稳定的白细胞和稳定的血小板或其类似物的完整的血细胞计数碱。
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公开(公告)号：US5945340A
公开(公告)日：1999-08-31
申请号：US227956
申请日：1999-01-11
申请人： Ralph T. Francis , Alan M. Johnson
发明人： Ralph T. Francis , Alan M. Johnson
CPC分类号： G01N33/96 , G01N33/80 , G01N2496/05 , Y10S435/81 , Y10T436/10 , Y10T436/101666 , Y10T436/25 , Y10T436/25125 , Y10T436/2525 , Y10T436/25375
摘要： A pre-determined concentration of stabilized, maturation-arrested porcine reticulocytes in a red blood cell base, useful as a reticulocyte control composition. The composition can be provided in the form of a concentrated reticulocyte composition, to be diluted to a desired final reticulocyte concentration at the time of use. The composition can also be provided in the form of a diluted, ready-to-use control composition. Also included is a method of preparing such a composition, the method involving sequential steps of forming and sedimenting Rouleaux bodies.
摘要翻译： 在红细胞基质中预定浓度的稳定化成熟的猪网织红细胞，可用作网织红细胞控制组合物。 组合物可以以浓缩的网织红细胞组合物的形式提供，在使用时稀释至所需的最终网织红细胞浓度。 组合物也可以以稀释的即用型控制组合物的形式提供。 还包括制备这种组合物的方法，该方法包括形成和沉降Rouleaux体的顺序步骤。
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公开(公告)号：US07267980B1
公开(公告)日：2007-09-11
申请号：US10407499
申请日：2003-04-04
CPC分类号： A01N1/00
摘要： Methods and compositions for stabilizing tissues, cells, and cell components such that desired antigenic sites, light scatter properties and cellular morphology are preserved for a useful period of time. The stabilizing solution includes glycine, lysine and formaldehyde.
摘要翻译： 用于稳定组织，细胞和细胞组分的方法和组合物，使得期望的抗原位点，光散射性质和细胞形态保持有用的一段时间。 稳定溶液包括甘氨酸，赖氨酸和甲醛。
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5.发明授权Cloning and expression of toxoplasma antigens and use of recombinant antigens 失效弓形体抗原的克隆和表达以及重组抗原的使用
公开(公告)号：US5578453A
公开(公告)日：1996-11-26
申请号：US972481
申请日：1993-04-12
申请人： Peter J. McDonald , Alan M. Johnson
发明人： Peter J. McDonald , Alan M. Johnson
CPC分类号： C07K14/45 , C07K16/20 , A61K38/00 , A61K39/00 , C07K2319/00 , C07K2319/23 , C07K2319/40 , Y10S530/822
摘要： A synthetic or recombinant polypeptide displaying the antigenicity of all or an antigenic fragment of the H4 or H11 polypeptides of Toxoplasma gondii, and recombinant DNA molecules, vectors and host cells for the expression thereof. Use of the polypeptide in vaccine compositions and in diagnostic immunoassays is also disclosed.
摘要翻译： PCT No.PCT / AU91 / 00347 Sec。 371日期：1993年4月12日 102（e）日期1993年4月12日PCT 1991年8月9日PCT PCT。 出版物WO92 / 02624 日期1992年2月20日一种显示弓形体的H4或H11多肽的全部或抗原性片段的抗原性的合成或重组多肽，以及其表达的重组DNA分子，载体和宿主细胞。 还公开了在疫苗组合物和诊断免疫测定中使用多肽。
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公开(公告)号：US07749757B1
公开(公告)日：2010-07-06
申请号：US11839172
申请日：2007-08-15
申请人： Frank Mortari , Paige M Johnson , Alan M Johnson
发明人： Frank Mortari , Paige M Johnson , Alan M Johnson
CPC分类号： A01N1/00
摘要： Methods and compositions for stabilizing tissues, cells, and cell components such that desired antigenic sites, light scatter properties and cellular morphology are preserved for a useful period of time. The stabilizing solution includes glycine, lysine and formaldehyde.
摘要翻译： 用于稳定组织，细胞和细胞组分的方法和组合物，使得期望的抗原位点，光散射性质和细胞形态保持有用的一段时间。 稳定溶液包括甘氨酸，赖氨酸和甲醛。
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公开(公告)号：US5736402A
公开(公告)日：1998-04-07
申请号：US695515
申请日：1996-08-12
申请人： Ralph T. Francis , Alan M. Johnson
发明人： Ralph T. Francis , Alan M. Johnson
CPC分类号： G01N33/96 , G01N33/80 , G01N2496/05 , Y10S435/81 , Y10T436/10 , Y10T436/101666 , Y10T436/25 , Y10T436/25125 , Y10T436/2525 , Y10T436/25375
摘要： A pre-determined concentration of stabilized, maturation-arrested porcine reticulocytes in a red blood cell base, useful as a reticulocyte control composition. The composition can be provided in the form of a concentrated reticulocyte composition, to be diluted to a desired final reticulocyte concentration at the time of use. The composition can also be provided in the form of a diluted, ready-to-use control composition. Also included is a method of preparing such a composition, the method involving sequential steps of forming and sedimenting Rouleaux bodies.
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