公开(公告)号：US08653071B2

公开(公告)日：2014-02-18

申请号：US13519298

申请日：2010-05-03

申请人： Ramakrishna Nirogi ,  Abdul Rasheed Mohammed ,  Kana Ram Kumawat ,  Ishtiyaque Ahmad ,  Pradeep Jayarajan ,  Anil Karbhari Shinde ,  Nagaraj Vishwottam Kandikere ,  Koteshwara Mudigonda ,  Venkateswarlu Jasti

发明人： Ramakrishna Nirogi ,  Abdul Rasheed Mohammed ,  Kana Ram Kumawat ,  Ishtiyaque Ahmad ,  Pradeep Jayarajan ,  Anil Karbhari Shinde ,  Nagaraj Vishwottam Kandikere ,  Koteshwara Mudigonda ,  Venkateswarlu Jasti

IPC分类号： A61K31/5377 ,  A61K31/497 ,  A61K31/496 ,  A61K31/4709 ,  A61K31/4427 ,  A61K31/404 ,  A61K31/403 ,  C07D413/14 ,  C07D401/02 ,  C07D401/14 ,  C07D215/00 ,  C07D209/04 ,  C07D209/02

CPC分类号： C07D401/14 ,  C07D401/04 ,  C07D401/06 ,  C07D403/04 ,  C07D403/06 ,  C07D405/06

摘要： The present invention relates to novel α4β2 neuronal nicotinic acetylcholine receptor ligand compounds of the formula (I), and their derivatives, stereoisomers, pharmaceutically acceptable salts and compositions containing them. The present invention relates to novel α4β2 neuronal nicotinic acetylcholine receptor ligand compounds of the formula (I), and their derivatives, stereoisomers, pharmaceutically acceptable salts and compositions containing them.

摘要翻译： 本发明涉及式（I）的新型α4beta2神经元烟碱乙酰胆碱受体配体化合物及其衍生物，立体异构体，药学上可接受的盐和含有它们的组合物。 本发明涉及式（I）的新型α4beta2神经元烟碱乙酰胆碱受体配体化合物及其衍生物，立体异构体，药学上可接受的盐和含有它们的组合物。

公开(公告)号：US20120322808A1

公开(公告)日：2012-12-20

申请号：US13519298

申请日：2010-05-03

申请人： Ramakrishna Nirogi ,  Abdul Rasheed Mohammed ,  Kana Ram Kumawat ,  Ishtiyaque Ahmad ,  Pradeep Jayarajan ,  Anil Karbhari Shinde ,  Nagaraj Vishwottam Kandikere ,  Koteshwara Mudigonda ,  Venkateswarlu Jasti

发明人： Ramakrishna Nirogi ,  Abdul Rasheed Mohammed ,  Kana Ram Kumawat ,  Ishtiyaque Ahmad ,  Pradeep Jayarajan ,  Anil Karbhari Shinde ,  Nagaraj Vishwottam Kandikere ,  Koteshwara Mudigonda ,  Venkateswarlu Jasti

IPC分类号： A61K31/403 ,  A61K31/4439 ,  A61P25/22 ,  A61P25/28 ,  A61P25/24 ,  A61P25/00 ,  A61P25/08 ,  A61P3/04 ,  A61P25/04 ,  C07D209/52 ,  C07D405/04 ,  C07D401/14 ,  A61K31/496 ,  A61K31/497 ,  C07D403/04 ,  A61K31/506 ,  C07D401/04 ,  A61K31/4709 ,  C07D401/06

CPC分类号： C07D401/14 ,  C07D401/04 ,  C07D401/06 ,  C07D403/04 ,  C07D403/06 ,  C07D405/06

摘要： The present invention relates to novel α4β2 neuronal nicotinic acetylcholine receptor ligand compounds of the formula (I), and their derivatives, stereoisomers, pharmaceutically acceptable salts and compositions containing them. The present invention relates to novel α4β2 neuronal nicotinic acetylcholine receptor ligand compounds of the formula (I), and their derivatives, stereoisomers, pharmaceutically acceptable salts and compositions containing them.

摘要翻译： 本发明涉及式（I）的新型α4和bgr2神经元烟碱乙酰胆碱受体配体化合物及其衍生物，立体异构体，药学上可接受的盐和含有它们的组合物。 本发明涉及式（I）的新型α4和bgr2神经元烟碱乙酰胆碱受体配体化合物及其衍生物，立体异构体，药学上可接受的盐和含有它们的组合物。

公开(公告)号：US08598204B2

公开(公告)日：2013-12-03

申请号：US13393539

申请日：2009-12-29

申请人： Ramakrishna Nirogi ,  Abdul Rasheed Mohammed ,  Ishtiyaque Ahmad ,  Pradeep Jayarajan ,  Nagaraj Vishwottam Kandikere ,  Anil Karbhari Shinde ,  Rama Sastri Kambhampati ,  Gopinadh Bhyrapuneni ,  Jyothsna Ravula ,  Sriramachandra Murthy Patnala ,  Venkateswarlu Jasti

发明人： Ramakrishna Nirogi ,  Abdul Rasheed Mohammed ,  Ishtiyaque Ahmad ,  Pradeep Jayarajan ,  Nagaraj Vishwottam Kandikere ,  Anil Karbhari Shinde ,  Rama Sastri Kambhampati ,  Gopinadh Bhyrapuneni ,  Jyothsna Ravula ,  Sriramachandra Murthy Patnala ,  Venkateswarlu Jasti

IPC分类号： A61K31/04 ,  C07D215/38

CPC分类号： C07D401/12 ,  C07D471/10 ,  C07D471/12

摘要： The present invention relates to novel 1,2-dihydro-2-oxoquinoline compounds of the formula (I), and their derivatives, prodrugs, tautomers, stereoisomers, polymorphs, solvates, hydrates, metabolites, N-oxides, pharmaceutically acceptable salts and compositions containing them. The present invention also relates to a process for the preparation of above said novel compounds, and their derivatives, prodrugs, tautomers, stereoisomers, polymorphs, solvates, hydrates, metabolites, N-oxides, pharmaceutically acceptable salts and compositions containing them.The compounds of the present invention are useful in the treatment/prevention of various disorders that are mediated by 5-HT4 receptor activity.

摘要翻译： 本发明涉及新的式（I）的1,2-二氢-2-氧代喹啉化合物及其衍生物，前体药物，互变异构体，立体异构体，多晶型物，溶剂化物，水合物，代谢物，N-氧化物，药学上可接受的盐和组合物 包含它们 本发明还涉及制备上述新化合物及其衍生物，前体药物，互变异构体，立体异构体，多晶型物，溶剂合物，水合物，代谢物，N-氧化物，药学上可接受的盐和含有它们的组合物的方法。 本发明的化合物可用于治疗/预防由5-HT4受体活性介导的各种疾病。

公开(公告)号：US20120277216A1

公开(公告)日：2012-11-01

申请号：US13393539

申请日：2009-12-29

申请人： Ramakrishna Nirogi ,  Abdul Rasheed Mohammed ,  Ishtiyaque Ahmad ,  Pradeep Jayarajan ,  Nagaraj Vishwottam Kandikere ,  Anil Karbhari Shinde ,  Rama Sastri Kambhampati ,  Gopinadh Bhyrapuneni ,  Jyothsna Ravula ,  Sriramachandra Murthy Patnala ,  Venkateswarlu Jasti

发明人： Ramakrishna Nirogi ,  Abdul Rasheed Mohammed ,  Ishtiyaque Ahmad ,  Pradeep Jayarajan ,  Nagaraj Vishwottam Kandikere ,  Anil Karbhari Shinde ,  Rama Sastri Kambhampati ,  Gopinadh Bhyrapuneni ,  Jyothsna Ravula ,  Sriramachandra Murthy Patnala ,  Venkateswarlu Jasti

IPC分类号： A61K31/4709 ,  C07D471/08 ,  C07D401/14 ,  A61P25/00 ,  A61K31/5377 ,  A61K31/55 ,  A61P25/28 ,  C07D401/12 ,  C07D413/12

CPC分类号： C07D401/12 ,  C07D471/10 ,  C07D471/12

摘要： The present invention relates to novel 1,2-dihydro-2-oxoquinoline compounds of the formula (I), and their derivatives, prodrugs, tautomers, stereoisomers, polymorphs, solvates, hydrates, metabolites, N-oxides, pharmaceutically acceptable salts and compositions containing them. The present invention also relates to a process for the preparation of above said novel compounds, and their derivatives, prodrugs, tautomers, stereoisomers, polymorphs, solvates, hydrates, metabolites, N-oxides, pharmaceutically acceptable salts and compositions containing them.The compounds of the present invention are useful in the treatment/prevention of various disorders that are mediated by 5-HT4 receptor activity.

摘要翻译： 本发明涉及新的式（I）的1,2-二氢-2-氧代喹啉化合物及其衍生物，前体药物，互变异构体，立体异构体，多晶型物，溶剂化物，水合物，代谢物，N-氧化物，药学上可接受的盐和组合物 包含它们 本发明还涉及制备上述新化合物及其衍生物，前体药物，互变异构体，立体异构体，多晶型物，溶剂合物，水合物，代谢物，N-氧化物，药学上可接受的盐和含有它们的组合物的方法。 本发明的化合物可用于治疗/预防由5-HT4受体活性介导的各种疾病。

公开(公告)号：US20110281849A1

公开(公告)日：2011-11-17

申请号：US13119385

申请日：2009-03-03

申请人： Ramakrishna Nirogi ,  Rama Sastri Kambhampati ,  Anil Karbhari Shinde ,  Ishtiyaque Ahmad ,  Nagaraj Vishwottam Kandikere ,  Venkateswarlu Jasti

发明人： Ramakrishna Nirogi ,  Rama Sastri Kambhampati ,  Anil Karbhari Shinde ,  Ishtiyaque Ahmad ,  Nagaraj Vishwottam Kandikere ,  Venkateswarlu Jasti

IPC分类号： A61K31/496 ,  A61K31/551 ,  A61P25/28 ,  C07D403/12

CPC分类号： C07D209/08 ,  C07D209/30

摘要： The present invention relates to novel aryl indolyl sulfonamide compounds of the formula (I), their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates described herein and pharmaceutically acceptable compositions containing them.

摘要翻译： 本发明涉及式（I）的新型芳基吲哚基磺酰胺化合物，其互变异构形式，其立体异构体，其多晶型物，其药学上可接受的盐，本文所述的其药学上可接受的溶剂合物和含有它们的药学上可接受的组合物。

公开(公告)号：US08318725B2

公开(公告)日：2012-11-27

申请号：US13119385

申请日：2009-03-03

申请人： Ramakrishna Nirogi ,  Rama Sastri Kambhampati ,  Anil Karbhari Shinde ,  Ishtiyaque Ahmad ,  Nagaraj Vishwottam Kandikere ,  Venkateswarlu Jasti

发明人： Ramakrishna Nirogi ,  Rama Sastri Kambhampati ,  Anil Karbhari Shinde ,  Ishtiyaque Ahmad ,  Nagaraj Vishwottam Kandikere ,  Venkateswarlu Jasti

IPC分类号： A01N43/62 ,  A61K31/55

CPC分类号： C07D209/08 ,  C07D209/30

摘要： The present invention relates to novel aryl indolyl sulfonamide compounds of the formula (I), their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates described herein and pharmaceutically acceptable compositions containing them.

摘要翻译： 本发明涉及式（I）的新型芳基吲哚基磺酰胺化合物，其互变异构形式，其立体异构体，其多晶型物，其药学上可接受的盐，本文所述的其药学上可接受的溶剂合物和含有它们的药学上可接受的组合物。

公开(公告)号：US08003670B2

公开(公告)日：2011-08-23

申请号：US12598616

申请日：2008-04-15

申请人： Ramakrishna Nirogi ,  Rama Sastri Kambhampati ,  Anil Karbhari Shinde ,  Anand Vijaykumar Daulatabad ,  Adi Reddy Dwarampudi ,  Nagaraj Vishwottam Kandikere ,  Santosh Vishwakarma ,  Venkateswarlu Jasti

发明人： Ramakrishna Nirogi ,  Rama Sastri Kambhampati ,  Anil Karbhari Shinde ,  Anand Vijaykumar Daulatabad ,  Adi Reddy Dwarampudi ,  Nagaraj Vishwottam Kandikere ,  Santosh Vishwakarma ,  Venkateswarlu Jasti

IPC分类号： A61K31/454 ,  A61K31/405 ,  C07D401/12 ,  C07D209/04

CPC分类号： C07D209/08 ,  C07D209/30 ,  C07D401/12

摘要： The present invention relates to novel aminoalkoxy arylsulfonamide compounds of the formula (I), their derivatives, their stereoisomers, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them. The present invention also relates to a process for the preparation of above said novel compounds, their derivatives, their stereoisomers, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them. These compounds are useful in the treatment of various disorders that are related to 5-HT6 receptor functions. Specifically, the compounds of this invention are also useful in the treatment of various CNS disorders, hematological disorders, eating disorders, diseases associated with pain, respiratory diseases, genito-urological disorders, cardiovascular diseases and cancer.

摘要翻译： 本发明涉及式（I）的新型氨基烷氧基芳基磺酰胺化合物，其衍生物，其立体异构体，其药学上可接受的盐和含有它们的药学上可接受的组合物。 本发明还涉及制备上述新化合物，其衍生物，其立体异构体，其药学上可接受的盐和含有它们的药学上可接受的组合物的方法。 这些化合物可用于治疗与5-HT 6受体功能相关的各种疾病。 具体地说，本发明的化合物也可用于治疗各种CNS病症，血液病症，进食障碍，与疼痛有关的疾病，呼吸系统疾病，泌尿系疾病，心血管疾病和癌症。

公开(公告)号：US07964627B2

公开(公告)日：2011-06-21

申请号：US12682596

申请日：2008-05-02

申请人： Nirogi Venkata Satya Ramakrishna ,  Rama Sastri Kambhampati ,  Anil Karbhari Shinde ,  Nagaraj Vishwottam Kandikere ,  Venkateswarlu Jasti

发明人： Nirogi Venkata Satya Ramakrishna ,  Rama Sastri Kambhampati ,  Anil Karbhari Shinde ,  Nagaraj Vishwottam Kandikere ,  Venkateswarlu Jasti

IPC分类号： A01N43/38 ,  C07D209/04

CPC分类号： C07D209/08

摘要： The present invention relates to novel amino arylsulfonamide compounds of the formula (I), their derivatives, their stereoisomers, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them: The present invention also relates to a process for the preparation of above said novel compounds, their derivatives, their stereoisomers, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them. The compounds of the invention are useful in the treatment of various disorders that are related to 5-HT6 receptor functions. Specifically, the compounds of this invention are also useful in the treatment of various CNS disorders, hematological disorders, eating disorders, obesity, anxiety, depression, diseases associated with pain, respiratory diseases, gastrointestinal, cardiovascular diseases and cancer.

摘要翻译： 本发明涉及式（I）的新型氨基芳基磺酰胺化合物，其衍生物，其立体异构体，其药学上可接受的盐和含有它们的药学上可接受的组合物：本发明还涉及制备上述新化合物的方法， 其衍生物，其立体异构体，其药学上可接受的盐和含有它们的药学上可接受的组合物。 本发明的化合物可用于治疗与5-HT 6受体功能相关的各种疾病。 具体地说，本发明的化合物还可用于治疗各种CNS疾病，血液病症，进食障碍，肥胖症，焦虑症，抑郁症，与疼痛相关的疾病，呼吸系统疾病，胃肠道，心血管疾病和癌症。

公开(公告)号：US20100216861A1

公开(公告)日：2010-08-26

申请号：US12682596

申请日：2008-05-02

申请人： Nirogi Venkata Satya Ramakrishna ,  Rama Sastri Kambhampati ,  Anil Karbhari Shinde ,  Nagaraj Vishwottam Kandikere ,  Venkateswarlu Jasti

发明人： Nirogi Venkata Satya Ramakrishna ,  Rama Sastri Kambhampati ,  Anil Karbhari Shinde ,  Nagaraj Vishwottam Kandikere ,  Venkateswarlu Jasti

IPC分类号： A61K31/405 ,  C07D209/14 ,  A61P3/04 ,  A61P25/22 ,  A61P25/18 ,  A61P25/24 ,  A61P25/28 ,  A61P1/00

CPC分类号： C07D209/08

摘要： The present invention relates to novel amino arylsulfonamide compounds of the formula (I), their derivatives, their stereoisomers, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them: The present invention also relates to a process for the preparation of above said novel compounds, their derivatives, their stereoisomers, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them. The compounds of the invention are useful in the treatment of various disorders that are related to 5-HT6 receptor functions. Specifically, the compounds of this invention are also useful in the treatment of various CNS disorders, hematological disorders, eating disorders, obesity, anxiety, depression, diseases associated with pain, respiratory diseases, gastrointestinal, cardiovascular diseases and cancer.

摘要翻译： 本发明涉及式（I）的新型氨基芳基磺酰胺化合物，其衍生物，其立体异构体，其药学上可接受的盐和含有它们的药学上可接受的组合物：本发明还涉及制备上述新化合物的方法， 其衍生物，其立体异构体，其药学上可接受的盐和含有它们的药学上可接受的组合物。 本发明的化合物可用于治疗与5-HT 6受体功能相关的各种疾病。 具体地说，本发明的化合物还可用于治疗各种CNS疾病，血液病症，进食障碍，肥胖症，焦虑症，抑郁症，与疼痛相关的疾病，呼吸系统疾病，胃肠道，心血管疾病和癌症。

公开(公告)号：US20100087484A1

公开(公告)日：2010-04-08

申请号：US12598616

申请日：2008-04-15

申请人： Nirogi Ramakrishna ,  Rama Sastri Kambhampati ,  Anil Karbhari Shinde ,  Anand Vijaykumar Daulatabad ,  Adi Reddy Dwarampudi ,  Nagaraj Vishwottam Kandikere ,  Santosh Vishwakarma ,  Venkateswarlu Jasti

发明人： Nirogi Ramakrishna ,  Rama Sastri Kambhampati ,  Anil Karbhari Shinde ,  Anand Vijaykumar Daulatabad ,  Adi Reddy Dwarampudi ,  Nagaraj Vishwottam Kandikere ,  Santosh Vishwakarma ,  Venkateswarlu Jasti

IPC分类号： A61K31/454 ,  C07D401/12 ,  A61K31/405 ,  C07D209/04

CPC分类号： C07D209/08 ,  C07D209/30 ,  C07D401/12

摘要： The present invention relates to novel aminoalkoxy arylsulfonamide compounds of the formula (I), their derivatives, their stereoisomers, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them. The present invention also relates to a process for the preparation of above said novel compounds, their derivatives, their stereoisomers, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them. These compounds are useful in the treatment of various disorders that are related to 5-HT6 receptor functions. Specifically, the compounds of this invention are also useful in the treatment of various CNS disorders, hematological disorders, eating disorders, diseases associated with pain, respiratory diseases, genito-urological disorders, cardiovascular diseases and cancer.

摘要翻译： 本发明涉及式（I）的新型氨基烷氧基芳基磺酰胺化合物，其衍生物，其立体异构体，其药学上可接受的盐和含有它们的药学上可接受的组合物。 本发明还涉及制备上述新化合物，其衍生物，其立体异构体，其药学上可接受的盐和含有它们的药学上可接受的组合物的方法。 这些化合物可用于治疗与5-HT 6受体功能相关的各种疾病。 具体地说，本发明的化合物也可用于治疗各种CNS病症，血液病症，进食障碍，与疼痛有关的疾病，呼吸系统疾病，泌尿系疾病，心血管疾病和癌症。