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9 条记录 (耗时 0.018 秒)

    Opthalmic solution for artificial tears
    2.
    发明授权
    Opthalmic solution for artificial tears 失效
    人造眼泪的光学解决方案

    公开(公告)号：US5895645A

    公开(公告)日：1999-04-20

    申请号：US702409

    申请日：1996-08-14

    申请人： Henry P. Dabrowski ,  Anil Salpekar ,  O. William Lever, Jr.

    发明人： Henry P. Dabrowski ,  Anil Salpekar ,  O. William Lever, Jr.

    IPC分类号： A61K9/00 ,  A61K31/16 ,  A61K31/395

    CPC分类号： A61K9/0048

    摘要： An ophthalmic artificial tear solution is described for treating irritation and dryness of the eyes with a formulation that includes polyvinylpyrrolidone, a preservative such as benzalkonium chloride, glycerin and hydroxypropyl methylcellulose, wherein the composition is an aqueous solution having isotonic properties with respect to the eye. The ophthalmic solution of the invention is characterized as having a low viscosity, preferably less than 5 cps, and a low surface tension, preferably less than 40 dynes/cm, wherein wettability, retainability and comfort of the user are enhanced.

    摘要翻译： 描述了一种用于用包括聚乙烯吡咯烷酮，防腐剂如苯扎氯铵，甘油和羟丙基甲基纤维素的制剂治疗眼睛的刺激和干燥的眼科人造泪液，其中该组合物是具有相对于眼睛具有等渗性质的水溶液。 本发明的眼用溶液的特征在于具有低粘度，优选小于5cps和低表面张力，优选小于40达因/厘米，其中增强了使用者的润湿性，保持性和舒适性。

    Tricyclic aromatic compounds
    3.
    发明授权
    Tricyclic aromatic compounds 失效
    三环芳香族化合物

    公开(公告)号：US4923892A

    公开(公告)日：1990-05-08

    申请号：US356884

    申请日：1989-05-23

    申请人： O. William Lever, Jr. ,  Harry J. Leighton

    发明人： O. William Lever, Jr. ,  Harry J. Leighton

    IPC分类号： C07C229/38 ,  C07D313/12 ,  C07D313/14

    CPC分类号： C07D313/12 ,  C07C229/38 ,  C07D313/14 ,  C07C2103/32 ,  Y10S514/826

    摘要： The present invention relates to compounds of formula I ##STR1## or a salt, ester or amide thereof; wherein R.sup.1 is --CH.sub.2 --CH.sub.2 --, CH.sub.2 --O-- or --O--CH.sub.2 --; R.sup.2 and R.sup.3 are the same or different and are each hydrogen, C.sub.1-4 alkyl or taken together with the nitrogen comprise a nitrogen-containing heterocyclic ring having four to six ring members; R.sup.4 is a single bond or a C.sub.1-7 bivalent aliphatic hydrocarbon group and may be joined to the aromatic ring system at the 2,3,8 or 9 positions; n is 0 to 3, and their use as antihistamine and antiasthma agents.

    摘要翻译： 本发明涉及式Ⅰ化合物或其盐，酯或酰胺; 其中R1是-CH2-CH2-，CH2-O-或-O-CH2-; R2和R3相同或不同，各自为氢，C1-4烷基或与氮一起包含含有4-6个环成员的含氮杂环; R4是单键或C1-7二价脂族烃基，并且可以在2,3,8或9位连接到芳环体系; n为0〜3，用作抗组胺药和止喘药。

    Method for providing rapid disinfection of contact lenses
    5.
    发明授权
    Method for providing rapid disinfection of contact lenses 失效
    提供隐形眼镜快速消毒的方法

    公开(公告)号：US5965088A

    公开(公告)日：1999-10-12

    申请号：US956514

    申请日：1997-10-23

    申请人： Andrea M. Lever ,  O. William Lever, Jr.

    发明人： Andrea M. Lever ,  O. William Lever, Jr.

    IPC分类号： A61L12/14 ,  A61L2/00

    CPC分类号： A61L12/142 ,  Y10S514/839 ,  Y10S514/84

    摘要： The present invention is directed to method of disinfecting a contact lens with an ophthalmically safe disinfecting aqueous solution comprising about 2.0 to about 8.0 ppm of a bis(biguanide) having the following formula: ##STR1## wherein R.sup.1 and R.sup.4 are independently selected from the group consisting of branched or unbranched alkyl having 4-12 carbon atoms, ether or thioether radical having 4-12 carbon atoms, or cycloalkyl or cycloalkyl-alky radical having 5-12 carbon atoms; R.sup.2 and R.sup.3 are independently selected from the group consisting of hydrogen, alkyl having 1-12 carbon atoms, alkoxyalkyl having 1-12 carbon atoms, or cycloalkyl or cycloalkyl-alkyl having 5-12, carbon atoms; R.sup.6 and R.sup.7 are independently selected from the group consisting of hydrogen and alkyl radical having 1-6 carbon atoms, and A in the above formula is selected from the group consisting of a divalent alkyl, alkyloxyalkyl, or alkylsufide radical each having 4-12 carbon atoms. The invention is also directed to a method of cleaning and/or disinfecting a contact lens within a minimum soaking period that is not more than about 75 minutes.

    摘要翻译： 本发明涉及用含有约2.0至约8.0ppm的具有下式的双（双胍）的眼用安全消毒水溶液消毒隐形眼镜的方法：其中R1和R4独立地选自支链 或具有4-12个碳原子的无支链烷基，具有4-12个碳原子的醚或硫醚基，或具有5-12个碳原子的环烷基或环烷基 - 烷基; R2和R3独立地选自氢，具有1-12个碳原子的烷基，具有1-12个碳原子的烷氧基烷基，或具有5-12个碳原子的环烷基或环烷基 - 烷基; R6和R7独立地选自氢和具有1-6个碳原子的烷基，上式中的A选自二价烷基，烷氧基烷基或烷基磺酰基，每一个具有4-12个碳原子 原子 本发明还涉及一种在不超过约75分钟的最小均热时间内清洁和/或消毒隐形眼镜的方法。

    Ophthalmic solution for artificial tears
    6.
    发明授权
    Ophthalmic solution for artificial tears 失效
    用于人造眼泪的眼科解决方案

    公开(公告)号：US5591426A

    公开(公告)日：1997-01-07

    申请号：US380931

    申请日：1995-01-31

    申请人： Henry P. Dabrowski ,  Anil Salpekar ,  O. William Lever, Jr.

    发明人： Henry P. Dabrowski ,  Anil Salpekar ,  O. William Lever, Jr.

    IPC分类号： A61K9/00 ,  A61K31/16 ,  A61K31/395

    CPC分类号： A61K9/0048

    摘要： An ophthalmic artificial tear solution is described for treating irritation and dryness of the eyes with a formulation that includes polyvinylpyrrolidone, a preservative such as benzalkonium chloride, glycerin and hydroxypropyl methylcellulose, wherein the composition is an aqueous solution having isotonic properties with respect to the eye. The ophthalmic solution of the invention is characterized as having a low viscosity, preferably less than 5 cps, and a low surface tension, preferably less than 40 dynes/cm, wherein wettability, retainability and comfort of the user are enhanced.

    摘要翻译： 描述了一种用于用包括聚乙烯吡咯烷酮，防腐剂如苯扎氯铵，甘油和羟丙基甲基纤维素的制剂治疗眼睛的刺激和干燥的眼科人造泪液，其中该组合物是具有相对于眼睛具有等渗性质的水溶液。 本发明的眼用溶液的特征在于具有低粘度，优选小于5cps和低表面张力，优选小于40达因/厘米，其中增强了使用者的润湿性，保持性和舒适性。