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公开(公告)号：US4623663A
公开(公告)日：1986-11-18
申请号：US812567
申请日：1985-12-23
IPC分类号： A61K31/135
CPC分类号： A61K31/135
摘要： A non-steroidal anti-inflammatory composition comprising an active anti-inflammatory agent having the formula: ##STR1## wherein R.sub.1 and R.sub.2 are hydrogen or lower alkyl C.sub.1-8. The active agent is formulated with a pharmaceutically acceptable carrier for use in the treatment of pain, inflammation and other related symptoms on mammals; preferably, R.sub.1 amd R.sub.2 are both methyl.
摘要翻译： 一种非甾体抗炎组合物，其包含具有下式的活性抗炎剂：其中R 1和R 2是氢或低级烷基C 1-8。 活性剂与药学上可接受的载体配制，用于治疗哺乳动物的疼痛，炎症和其它相关症状; 优选地，R 1 amd R 2都是甲基。
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2.发明授权Para-benzyloxyphenol non-steroidal anti-inflammatory compositions and method 失效对 - 苄氧基苯酚非甾体抗炎组合物及方法
公开(公告)号：US4568697A
公开(公告)日：1986-02-04
申请号：US622935
申请日：1984-06-21
IPC分类号： A61K31/085
CPC分类号： A61K31/085
摘要： A non-steroidal anti-inflammatory composition comprising an active anti-inflammatory agent having the formula: ##STR1## The active agent is formulated with a pharmaceutically acceptable carrier for use in the treatment of pain, inflammation and other related symptoms on mammals.
摘要翻译： 一种非甾体抗炎组合物，其包含具有下式的活性抗炎剂：活性剂与药学上可接受的载体配制，用于治疗哺乳动物的疼痛，炎症和其它相关症状。
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公开(公告)号：US06787131B2
公开(公告)日：2004-09-07
申请号：US10023351
申请日：2001-12-17
IPC分类号： A61K3174
CPC分类号： A61K9/0048 , A61K31/203
摘要： A method for improving the integrity of the corneal epithelium by introducing into the eye an effective amount of a ophthalmically compatible retinoid sufficient to enhance the integrity of the corneal epithelium.
摘要翻译： 通过向眼睛中引入足以增强角膜上皮完整性的有效量的眼科相容的类视黄醇来改善角膜上皮的完整性的方法。
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4.发明授权Composition and method for inhibiting uptake of biguanide antimicrobials by hydrogels 失效通过水凝胶抑制双胍类抗菌素摄取的组合物和方法公开(公告)号：US06528464B1
公开(公告)日：2003-03-04
申请号：US09932356
申请日：2001-08-17
IPC分类号： C11D348
CPC分类号： A61L12/141 , A61L12/142 , Y10S514/839 , Y10S514/84
摘要： The invention provides a method for inhibiting the binding of a biguanide antimicrobial in aqueous solution to a hydrogel in contact with said solution comprising providing in said solution an amount of cyclodextrin sufficient to inhibit sorption of the biguanide antimicrobial to a hydrogel.
摘要翻译： 本发明提供了一种抑制双胍类抗微生物剂在水溶液中与与所述溶液接触的水凝胶的结合的方法，包括在所述溶液中提供足以抑制双胍类抗微生物剂吸附至水凝胶的量的环糊精。
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公开(公告)号：US4559328A
公开(公告)日：1985-12-17
申请号：US623271
申请日：1984-06-21
IPC分类号： A61K31/05 , A61K31/085 , A61K31/165 , A61K31/60 , A61K31/015 , A61K31/075 , A61K31/19
CPC分类号： A61K31/60 , A61K31/05 , A61K31/085 , A61K31/165
摘要： A non-steroidal anti-inflammatory composition comprising an active anti-inflammatory agent having the formula: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 is hydrogen, hydroxy, phenyl, methoxy, carboxylic acid, sulfhydryl or hydroxamic acid.The active agent is formulated with a pharmaceutically acceptable carrier for use in the treatment of pain, inflammation and other related symptoms on mammals. p-Hydroxydiphenyl, p-methoxyphenol, thiosalicylic acid, benzyl alcohol and salicylhydroxamic acid are preferred.
摘要翻译： 一种非甾体抗炎组合物，其包含具有下式的活性抗炎剂：其中R1，R2和R3是氢，羟基，苯基，甲氧基，羧酸，巯基或异羟肟酸。 活性剂与药学上可接受的载体配制，用于治疗哺乳动物的疼痛，炎症和其它相关症状。 对羟基二苯基，对甲氧基苯酚，硫代水杨酸，苄醇和水杨基异羟肟酸是优选的。
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公开(公告)号：US20120028947A1
公开(公告)日：2012-02-02
申请号：US13239612
申请日：2011-09-22
CPC分类号： A61K9/0048 , A61K9/06 , A61K31/56 , A61K47/10 , A61K47/183 , A61K47/186 , A61K47/32
摘要： An aqueous ophthalmic composition comprising loteprednol etabonate, and polyacryclic acid. The composition has a viscosity in the range from about 300 cp to about 1500 cp, and a total concentration of cations of less than about 50 mM. The ophthalmic composition is used to treat patients suffering from allergic conjunctivitis, and includes instructing a person suffering from ocular itching resulting from allergic conjunctivitis to administer once or twice daily in the form of one or more eye drops the aqueous ophthalmic composition described.
摘要翻译： 一种水性眼用组合物，其包含氯普非醇酯和聚丙烯酸。 组合物的粘度范围为约300cp至约1500cp，阳离子的总浓度小于约50mM。 眼用组合物用于治疗患有过敏性结膜炎的患者，并且包括指示患有由过敏性结膜炎引起的眼痒的人每天一次或两次以一种或多种眼药水的形式给予描述的眼用组合物。
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公开(公告)号：US4780249A
公开(公告)日：1988-10-25
申请号：US867116
申请日：1986-05-23
IPC分类号： A61K8/37 , A61K8/40 , A61K8/42 , A61K8/44 , A61K8/46 , A61K8/55 , A61K8/86 , A61Q17/00 , C11D1/14 , C11D1/62
CPC分类号： A61Q17/00 , A61K8/375 , A61K8/40 , A61K8/42 , A61K8/44 , A61K8/463 , A61K8/553 , A61K8/86 , A61Q19/10 , A61K2800/75
摘要： A process and composition for inhibiting surfactant irritation and insult comprising an aqueous solution of a surfactant and an effective amount of an irritation inhibitor selected from the group consisting of lecithin, sodium cetearyl sulfate, an amino acid, cocamine compounds, amine oxides, glyceryl monoesters, ethoxylated monocarboxylic acids, ethoxylated hydroxyl compounds and mixtures thereof.
摘要翻译： 一种用于抑制表面活性剂刺激和损伤的方法和组合物，其包括表面活性剂的水溶液和有效量的刺激抑制剂，其选自卵磷脂，硫酸鲸蜡硬脂酸酯，氨基酸，椰子胺化合物，氧化胺，甘油单酯， 乙氧基化单羧酸，乙氧基化羟基化合物及其混合物。
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公开(公告)号：US4672076A
公开(公告)日：1987-06-09
申请号：US604789
申请日：1984-04-27
IPC分类号： A61K31/235 , A61K31/60 , C07C69/767
CPC分类号： A61K31/235 , A61K31/60
摘要： A non-steroidal anti-inflammatory composition comprising an active anti-inflammatory agent having the formula: ##STR1## wherein R.sub.1 and R.sub.2 are hydrogen hydroxy. The active agent is formulated with a pharmaceutically acceptable carrier for use in the treatment of pain, inflammation and other related symptoms on mammals. Benzyl paraben, benzyl salicylate and benzyl benzoate are preferred.
摘要翻译： 一种非甾体抗炎组合物，其包含具有下式的活性抗炎剂：其中R1和R2是氢羟基。 活性剂与药学上可接受的载体配制，用于治疗哺乳动物的疼痛，炎症和其它相关症状。 对羟基苯甲酸苄酯，水杨酸苄酯和苯甲酸苄酯是优选的。
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公开(公告)号：US20100234336A1
公开(公告)日：2010-09-16
申请号：US12732639
申请日：2010-03-26
IPC分类号： A61K31/566 , A61P27/02
CPC分类号： A61K9/0048 , A61K9/06 , A61K31/573 , A61K47/10 , A61K47/183 , A61K47/186 , A61K47/32
摘要： An aqueous ophthalmic composition comprises a carboxy-containing polyanionic polymer that has a viscosity in the range from about 300 cp to about 1500 cp outside the eye and a total concentration of cations of less than about 50 mM, wherein the viscosity of the composition does not increase when the composition comes into contact with surface ocular fluid.
摘要翻译： 水性眼用组合物包含含羧基的聚阴离子聚合物，其粘度在眼外约300cp至约1500cp，阳离子的总浓度小于约50mM，其中组合物的粘度不为 当组合物与表面眼液接触时增加。
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公开(公告)号：US06703039B2
公开(公告)日：2004-03-09
申请号：US09731290
申请日：2000-12-06
申请人： Erning Xia , Richard V. Smerbeck
发明人： Erning Xia , Richard V. Smerbeck
IPC分类号： A61F200
CPC分类号： A61K47/10 , A61K9/0048 , A61K47/36
摘要： The invention provides an ophthalmic aqueous composition for topical administration, comprising: (a) a block copolymer of propylene oxide and ethylene oxide in concentration sufficient to provide viscosity of less than about 25 centipoise at ambient temperature and viscosity of from about 25 to about 55 centipoise when applied topically to a patient; (b) hydroxypropyl methylcellulose in concentration sufficient to improve the durability of the gel formed by the block copolymer. The invention further provides a method for administering ophthalmic pharmaceuticals.
摘要翻译： 本发明提供了一种用于局部给药的眼用含水组合物，其包含：（a）环氧丙烷和环氧乙烷的嵌段共聚物，其浓度足以在环境温度下提供小于约25厘泊的粘度，粘度为约25至约55厘泊 当局部应用于患者时;（b）羟丙基甲基纤维素的浓度足以提高由嵌段共聚物形成的凝胶的耐久性。本发明还提供了一种眼科药物的给药方法。
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